Trends in Childhood Oncology Admissions to ICUs in Australia and New Zealand.
Journal
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
ISSN: 1529-7535
Titre abrégé: Pediatr Crit Care Med
Pays: United States
ID NLM: 100954653
Informations de publication
Date de publication:
03 May 2023
03 May 2023
Historique:
pubmed:
3
5
2023
medline:
3
5
2023
entrez:
3
5
2023
Statut:
aheadofprint
Résumé
There are few robust, national-level reports of contemporary trends in pediatric oncology admissions, resource use, and mortality. We aimed to describe national-level data on trends in intensive care admissions, interventions, and survival for children with cancer. Cohort study using a binational pediatric intensive care registry. Australia and New Zealand. Patients younger than 16 years, admitted to an ICU in Australia or New Zealand with an oncology diagnosis between January 1, 2003, and December 31, 2018. None. We examined trends in oncology admissions, ICU interventions, and both crude and risk-adjusted patient-level mortality. Eight thousand four hundred ninety admissions were identified for 5,747 patients, accounting for 5.8% of PICU admissions. Absolute and population-indexed oncology admissions increased from 2003 to 2018, and median length of stay increased from 23.2 hours (interquartile range [IQR], 16.8-62 hr) to 38.8 hours (IQR, 20.9-81.1 hr) ( p < 0.001). Three hundred fifty-seven of 5,747 patients died (6.2%). There was a 45% reduction in risk-adjusted ICU mortality, which reduced from 3.3% (95% CI, 2.1-4.4) in 2003-2004 to 1.8% (95% CI, 1.1-2.5%) in 2017-2018 ( p trend = 0.02). The greatest reduction in mortality seen in hematological cancers and in nonelective admissions. Mechanical ventilation rates were unchanged from 2003 to 2018, while the use of high-flow nasal prong oxygen increased (incidence rate ratio, 2.43; 95% CI, 1.61-3.67 per 2 yr). In Australian and New Zealand PICUs, pediatric oncology admissions are increasing steadily and such admissions are staying longer, representing a considerable proportion of ICU activity. The mortality of children with cancer who are admitted to ICU is low and falling.
Identifiants
pubmed: 37133322
doi: 10.1097/PCC.0000000000003268
pii: 00130478-990000000-00197
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Anusha Ganeshalingam
(A)
Claire Sherring
(C)
Simon Erickson
(S)
Samantha Barr
(S)
Sainath Raman
(S)
Debbie Long
(D)
Luregn Schlapbach
(L)
Kristen Gibbons
(K)
Shane George
(S)
Puneet Singh
(P)
Vicky Smith
(V)
Warwick Butt
(W)
Carmel Delzoppo
(C)
Johnny Millar
(J)
Ben Gelbart
(B)
Felix Oberender
(F)
Subodh Ganu
(S)
Georgia Letton
(G)
Marino Festa
(M)
Gail Harper
(G)
Informations de copyright
Copyright © 2023 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
Déclaration de conflit d'intérêts
The authors have disclosed that they do not have any potential conflicts of interest.
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