SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
07 08 2023
07 08 2023
Historique:
received:
01
09
2022
revised:
09
02
2023
accepted:
07
04
2023
medline:
5
5
2023
pubmed:
3
5
2023
entrez:
3
5
2023
Statut:
ppublish
Résumé
SARS-CoV-2 infection for most children results in mild or minimal symptoms, though in rare cases severe disease can develop, including a multisystem inflammatory syndrome (MIS-C) with myocarditis. Here, we present longitudinal profiling of immune responses during acute disease and following recovery in children who developed MIS-C, relative to children who experienced more typical symptoms of COVID-19. T cells in acute MIS-C exhibited transient signatures of activation, inflammation, and tissue residency which correlated with cardiac disease severity, while T cells in acute COVID-19 upregulated markers of follicular helper T cells for promoting antibody production. The resultant memory immune response in recovery showed increased frequencies of virus-specific memory T cells with pro-inflammatory functions in children with prior MIS-C compared to COVID-19 while both cohorts generated comparable antibody responses. Together our results reveal distinct effector and memory T cell responses in pediatric SARS-CoV-2 infection delineated by clinical syndrome, and a potential role for tissue-derived T cells in the immune pathology of systemic disease.
Identifiants
pubmed: 37133746
pii: 214087
doi: 10.1084/jem.20221518
pmc: PMC10163842
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : U01 AI100119
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM145440
Pays : United States
Organisme : NIH HHS
ID : S10 OD030282
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001873
Pays : United States
Organisme : NIH HHS
ID : S10 OD020056
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI128949
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016520
Pays : United States
Informations de copyright
© 2023 Rybkina et al.
Références
Virus Genes. 2006 Oct;33(2):235-52
pubmed: 16972040
J Allergy Clin Immunol. 2001 Oct;108(4):594-601
pubmed: 11590387
Cell Rep. 2017 Sep 19;20(12):2921-2934
pubmed: 28930685
Nat Med. 2020 Jul;26(7):1033-1036
pubmed: 32398876
TH Open. 2020 Jun 26;4(2):e138-e144
pubmed: 32607467
N Engl J Med. 2022 Feb 10;386(6):599-601
pubmed: 35030645
Pediatrics. 2021 Aug;148(2):
pubmed: 34266903
Cell. 2020 Nov 12;183(4):982-995.e14
pubmed: 32991843
mSphere. 2021 Aug 25;6(4):e0057121
pubmed: 34319126
Sci Transl Med. 2022 Mar 23;14(637):eabn8057
pubmed: 35166573
J Clin Invest. 2020 Nov 2;130(11):5967-5975
pubmed: 32730233
Circulation. 2020 Dec 8;142(23):2282-2284
pubmed: 33112651
Lancet Respir Med. 2021 Apr;9(4):e32-e34
pubmed: 33617781
J Allergy Clin Immunol. 2021 Jan;147(1):57-59
pubmed: 33075409
Nat Immunol. 2011 Jun;12(6):492-9
pubmed: 21739672
N Engl J Med. 2020 Jul 23;383(4):334-346
pubmed: 32598831
Front Immunol. 2022 Jan 18;12:793197
pubmed: 35116027
Front Immunol. 2022 Jul 07;13:941009
pubmed: 35874696
Cells. 2021 Aug 20;10(8):
pubmed: 34440912
Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25254-25262
pubmed: 32989130
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Pediatr Radiol. 2023 Mar;53(3):394-403
pubmed: 36255453
Pediatr Crit Care Med. 2021 Mar 1;22(3):e178-e191
pubmed: 33003176
JAMA Netw Open. 2022 Feb 1;5(2):e2143151
pubmed: 35133437
Science. 2016 Apr 22;352(6284):459-63
pubmed: 27102484
Genome Biol. 2014;15(12):550
pubmed: 25516281
Blood Adv. 2020 Apr 14;4(7):1378-1382
pubmed: 32267929
Nat Immunol. 2021 Nov;22(11):1452-1464
pubmed: 34611361
Immunity. 2021 Apr 13;54(4):797-814.e6
pubmed: 33765436
J Virol. 2009 May;83(10):5148-55
pubmed: 19264786
Nat Immunol. 2021 Jan;22(1):25-31
pubmed: 33154590
Semin Immunopathol. 2016 Jul;38(4):471-82
pubmed: 26965109
Annu Rev Immunol. 2011;29:621-63
pubmed: 21314428
Leukemia. 2003 Dec;17(12):2257-317
pubmed: 14671650
Lancet. 2020 May 23;395(10237):1607-1608
pubmed: 32386565
Nat Med. 2009 Mar;15(3):277-84
pubmed: 19234462
PLoS One. 2012;7(3):e30538
pubmed: 22396728
N Engl J Med. 2020 Jul 9;383(2):187-190
pubmed: 32356945
Nat Commun. 2019 Oct 17;10(1):4706
pubmed: 31624246
Front Immunol. 2022 Mar 11;13:841126
pubmed: 35360001
J Am Heart Assoc. 2022 Feb;11(3):e023251
pubmed: 35043684
Nat Methods. 2015 May;12(5):380-1
pubmed: 25924071
Nat Med. 2022 May;28(5):1050-1062
pubmed: 35177862
Int J Mol Sci. 2022 Jun 29;23(13):
pubmed: 35806225
Cell. 2020 Nov 12;183(4):968-981.e7
pubmed: 32966765
Sci Immunol. 2021 May 25;6(59):
pubmed: 34035116
PLoS Comput Biol. 2015 Nov 25;11(11):e1004503
pubmed: 26606115
N Engl J Med. 2020 Apr 23;382(17):1663-1665
pubmed: 32187458
J Clin Invest. 2021 Jul 15;131(14):
pubmed: 34032635
Genome Med. 2021 Jun 14;13(1):100
pubmed: 34127056
J Clin Invest. 2021 May 17;131(10):
pubmed: 33705359
PLoS One. 2017 Oct 24;12(10):e0186998
pubmed: 29065175
Bioinformatics. 2014 Jul 1;30(13):1930-2
pubmed: 24618469
Science. 2021 Mar 26;371(6536):1379-1382
pubmed: 33597220
Lancet Rheumatol. 2021 Sep;3(9):e615-e616
pubmed: 34337437
Lancet Rheumatol. 2021 Aug;3(8):e574-e584
pubmed: 34124694
PLoS One. 2012;7(8):e43603
pubmed: 22928001
Crit Care Clin. 2013 Jul;29(3):651-75
pubmed: 23830657
Sci Immunol. 2021 Mar 2;6(57):
pubmed: 33653907
Science. 2021 Feb 5;371(6529):
pubmed: 33408181
Lancet. 2020 Jun 6;395(10239):1771-1778
pubmed: 32410760
Immunity. 2021 May 11;54(5):1083-1095.e7
pubmed: 33891889
Lancet Child Adolesc Health. 2022 May;6(5):294-302
pubmed: 35189083
Sci Transl Med. 2020 Oct 7;12(564):
pubmed: 32958614
J Med Virol. 2020 Jan;92(1):26-33
pubmed: 31475732
Nat Med. 2020 Nov;26(11):1701-1707
pubmed: 32812012
J Immunol Res. 2017;2017:6104054
pubmed: 28316998
Nature. 2020 Aug;584(7821):463-469
pubmed: 32717743
Sci Immunol. 2019 Apr 5;4(34):
pubmed: 30952804
Clin Immunol. 2022 Oct;243:109106
pubmed: 36049601
J Clin Invest. 2021 Oct 15;131(20):
pubmed: 34437303
J Immunol. 2000 Apr 1;164(7):3862-9
pubmed: 10725748
JCI Insight. 2017 Jul 6;2(13):
pubmed: 28679951
JAMA. 2020 Jul 21;324(3):294-296
pubmed: 32511676
J Clin Invest. 2020 Nov 2;130(11):5942-5950
pubmed: 32701511
Nat Rev Rheumatol. 2021 Dec;17(12):731-748
pubmed: 34716418
Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12306-12314
pubmed: 32439709
JAMA Pediatr. 2022 Aug 1;176(8):811-813
pubmed: 35363246
J Exp Med. 2022 Feb 7;219(2):
pubmed: 34914824
Science. 2020 Aug 7;369(6504):718-724
pubmed: 32661059