Tumor-derived interleukin-1α and leukemia inhibitory factor promote extramedullary hematopoiesis.
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
27
06
2022
accepted:
06
02
2023
medline:
5
5
2023
pubmed:
3
5
2023
entrez:
3
5
2023
Statut:
epublish
Résumé
Extramedullary hematopoiesis (EMH) expands hematopoietic capacity outside of the bone marrow in response to inflammatory conditions, including infections and cancer. Because of its inducible nature, EMH offers a unique opportunity to study the interaction between hematopoietic stem and progenitor cells (HSPCs) and their niche. In cancer patients, the spleen frequently serves as an EMH organ and provides myeloid cells that may worsen pathology. Here, we examined the relationship between HSPCs and their splenic niche in EMH in a mouse breast cancer model. We identify tumor produced IL-1α and leukemia inhibitory factor (LIF) acting on splenic HSPCs and splenic niche cells, respectively. IL-1α induced TNFα expression in splenic HSPCs, which then activated splenic niche activity, while LIF induced proliferation of splenic niche cells. IL-1α and LIF display cooperative effects in activating EMH and are both up-regulated in some human cancers. Together, these data expand avenues for developing niche-directed therapies and further exploring EMH accompanying inflammatory pathologies like cancer.
Identifiants
pubmed: 37134077
doi: 10.1371/journal.pbio.3001746
pii: PBIOLOGY-D-22-01418
pmc: PMC10155962
doi:
Substances chimiques
Leukemia Inhibitory Factor
0
Interleukin-1alpha
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3001746Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007163
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL055337
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI049653
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149954
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright: © 2023 Barisas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Nat Med. 2018 Jun;24(6):711-720
pubmed: 29867229
Nat Commun. 2019 Jul 11;10(1):3055
pubmed: 31296870
Cancer Cell. 2021 Jun 14;39(6):845-865.e7
pubmed: 34019806
Nature. 2001 Apr 26;410(6832):1107-11
pubmed: 11323675
Cancers (Basel). 2020 Apr 13;12(4):
pubmed: 32295078
Gigascience. 2020 Dec 26;9(12):
pubmed: 33367645
Rheumatology (Oxford). 2010 Jul;49(7):1215-28
pubmed: 20194223
Blood. 2019 Feb 21;133(8):816-819
pubmed: 30301719
Nat Genet. 2013 Oct;45(10):1113-20
pubmed: 24071849
J Clin Invest. 2019 May 14;129(7):2745-2759
pubmed: 31085833
J Natl Cancer Inst. 2014 May 29;106(6):dju124
pubmed: 24875653
Exp Hematol. 2006 Aug;34(8):1010-20
pubmed: 16863907
Sci Rep. 2020 Oct 30;10(1):18758
pubmed: 33127996
Cell Rep. 2020 Dec 22;33(12):108530
pubmed: 33357430
Cell Rep. 2013 May 30;3(5):1714-24
pubmed: 23623496
Nature. 2019 May;569(7755):222-228
pubmed: 30971824
Nat Protoc. 2012 Dec;7(12):2103-11
pubmed: 23154782
Blood. 2012 Sep 13;120(11):2203-13
pubmed: 22855602
Cancer Res. 1955 Jan;15(1):38-51
pubmed: 13231073
Cell. 2005 Jul 1;121(7):1109-21
pubmed: 15989959
Nature. 2013 Mar 14;495(7440):231-5
pubmed: 23434755
Nature. 2010 Aug 12;466(7308):829-34
pubmed: 20703299
Nat Cell Biol. 2016 Jun;18(6):607-18
pubmed: 27111842
Blood. 2017 Apr 6;129(14):1901-1912
pubmed: 28179275
J Blood Med. 2010;1:13-9
pubmed: 22282679
Genome Biol. 2019 Dec 23;20(1):296
pubmed: 31870423
Nat Rev Immunol. 2021 Aug;21(8):485-498
pubmed: 33526920
Nat Commun. 2014 Oct 17;5:5218
pubmed: 25323535
Blood. 2005 Jul 1;106(1):86-94
pubmed: 15769895
Immunity. 2019 Feb 19;50(2):288-301
pubmed: 30784577
J Bone Miner Res. 1991 Dec;6(12):1277-83
pubmed: 1792939
Development. 1995 May;121(5):1283-99
pubmed: 7789261
Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E566-75
pubmed: 25624500
Cell Rep Med. 2023 Jan 17;4(1):100896
pubmed: 36630952
Cell Tissue Kinet. 1978 Jul;11(4):335-45
pubmed: 356997
Nature. 2015 Nov 26;527(7579):466-471
pubmed: 26570997
J Neurosci. 2012 Feb 8;32(6):2100-9
pubmed: 22323722
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2491-6
pubmed: 22308361
J Exp Med. 2013 Jul 1;210(7):1351-67
pubmed: 23776077
Medicine (Baltimore). 2018 Mar;97(12):e0144
pubmed: 29561419
Cell Rep. 2014 Jun 12;7(5):1664-1678
pubmed: 24857661
Nat Rev Cancer. 2020 Mar;20(3):174-186
pubmed: 31980749
Nature. 1993 May 27;363(6427):361-4
pubmed: 8497320
Exp Hematol. 1997 Jun;25(6):542-7
pubmed: 9197334
Immunity. 2018 Apr 17;48(4):632-648
pubmed: 29669248
Cell. 2018 Jan 11;172(1-2):191-204.e10
pubmed: 29224778
J Immunol. 2000 May 1;164(9):4783-9
pubmed: 10779785
Cytokine Growth Factor Rev. 2015 Oct;26(5):533-44
pubmed: 26187859
Nat Rev Immunol. 2017 Sep;17(9):573-590
pubmed: 28604734
Cancers (Basel). 2021 Jan 26;13(3):
pubmed: 33530653
Immunity. 2013 Nov 14;39(5):806-18
pubmed: 24238338
Endocrinology. 2017 Jun 1;158(6):1916-1928
pubmed: 28368537
Exp Hematol. 1994 Feb;22(2):174-7
pubmed: 7507859
Cancer Res. 2019 Jan 15;79(2):346-359
pubmed: 30389698
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
Oncoimmunology. 2017 Feb 6;6(3):e1287247
pubmed: 28405519
Oncotarget. 2014 Feb 15;5(3):788-801
pubmed: 24553191
Cell Stem Cell. 2019 Sep 5;25(3):357-372.e7
pubmed: 31230859
Immunity. 2010 Sep 24;33(3):387-99
pubmed: 20850355
Blood. 2009 Nov 12;114(20):4402-10
pubmed: 19759358
Mol Cell Biol. 1992 Mar;12(3):954-61
pubmed: 1312220
Cancer Res. 2007 Mar 1;67(5):2131-40
pubmed: 17332343
Nature. 2019 May;569(7754):131-135
pubmed: 30996350
Nature. 2018 Oct;562(7727):367-372
pubmed: 30283141
Transfus Med Hemother. 2008;35(3):168-184
pubmed: 21547115
Cell Stem Cell. 2014 Apr 3;14(4):445-459
pubmed: 24561084
Cell. 2020 Aug 20;182(4):886-900.e17
pubmed: 32783918
J Cell Physiol. 1992 Aug;152(2):264-73
pubmed: 1639861
Nat Commun. 2018 Mar 28;9(1):1250
pubmed: 29593283
J Clin Invest. 2018 Aug 1;128(8):3425-3438
pubmed: 29771686
Nat Commun. 2019 Jun 11;10(1):2416
pubmed: 31186412
Cancer Manag Res. 2018 Jun 08;10:1461-1470
pubmed: 29922090
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Blood. 2022 Jan 6;139(1):44-58
pubmed: 34525198
Genome Biol. 2017 Nov 15;18(1):220
pubmed: 29141660
Nature. 2012 Jan 25;481(7382):457-62
pubmed: 22281595
Front Immunol. 2020 Oct 26;11:586527
pubmed: 33193412
Immunity. 2006 Dec;25(6):977-88
pubmed: 17174120
Blood Cancer J. 2018 Nov 19;8(12):119
pubmed: 30455416