Adverse outcomes and maternal complications in pregnant women with severe-critical COVID-19: a tertiary center experience.
critical care
maternal mortality
newborn
pregnancy
preterm birth
severe-critical COVID-19
Journal
Journal of perinatal medicine
ISSN: 1619-3997
Titre abrégé: J Perinat Med
Pays: Germany
ID NLM: 0361031
Informations de publication
Date de publication:
26 Sep 2023
26 Sep 2023
Historique:
received:
21
11
2022
accepted:
19
01
2023
medline:
8
9
2023
pubmed:
3
5
2023
entrez:
3
5
2023
Statut:
epublish
Résumé
This study aimed to present perinatal outcomes, clinical challenges, and basic ICU management in pregnant women with severe-critical COVID-19 at our tertiary referral center. In this prospective cohort study, patients were divided into two groups, whether they survived or not. Clinical characteristics, obstetric and neonatal outcomes, initial laboratory test results and radiologic imaging findings, arterial blood gas parameters at ICU admission, and ICU complications and interventions were compared between groups. 157 of the patients survived, and 34 of the patients died. Asthma was the leading health problem among the non-survivors. Fifty-eight patients were intubated, and 24 of them were weaned off and discharged healthfully. Of the 10 patients who underwent ECMO, only 1 survived (p<0.001). Preterm labor was the most common pregnancy complication. Maternal deterioration was the most common indication for a cesarean section. Higher neutrophil-to-lymphocyte-ratio (NLR) values, the need for prone positioning, and the occurrence of an ICU complication were important parameters that influenced maternal mortality (p<0.05). Overweight pregnant women and pregnant women with comorbidities, especially asthma, may have a higher risk of mortality related to COVID-19. A worsening maternal health condition can lead to increased rates of cesarean delivery and iatrogenic prematurity.
Identifiants
pubmed: 37134274
pii: jpm-2022-0564
doi: 10.1515/jpm-2022-0564
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
874-885Informations de copyright
© 2023 Walter de Gruyter GmbH, Berlin/Boston.
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