Ultrasmall, elementary and highly translational nanoparticle X-ray contrast media from amphiphilic iodinated statistical copolymers.

Amphiphilic statistical iodocopolymer CT Longitudinal tumor monitoring PET/CT Ultrasmall nanoassembly X-ray contrast media

Journal

Acta pharmaceutica Sinica. B
ISSN: 2211-3835
Titre abrégé: Acta Pharm Sin B
Pays: Netherlands
ID NLM: 101600560

Informations de publication

Date de publication:
Apr 2023
Historique:
received: 21 07 2022
revised: 18 08 2022
accepted: 05 09 2022
medline: 4 5 2023
pubmed: 4 5 2023
entrez: 4 5 2023
Statut: ppublish

Résumé

To expand the single-dose duration over which noninvasive clinical and preclinical cancer imaging can be conducted with high sensitivity, and well-defined spatial and temporal resolutions, a facile strategy to prepare ultrasmall nanoparticulate X-ray contrast media (nano-XRCM) as dual-modality imaging agents for positron emission tomography (PET) and computed tomography (CT) has been established. Synthesized from controlled copolymerization of triiodobenzoyl ethyl acrylate and oligo(ethylene oxide) acrylate monomers, the amphiphilic statistical iodocopolymers (ICPs) could directly dissolve in water to afford thermodynamically stable solutions with high aqueous iodine concentrations (>140 mg iodine/mL water) and comparable viscosities to conventional small molecule XRCM. The formation of ultrasmall iodinated nanoparticles with hydrodynamic diameters of

Identifiants

DOI: 10.1016/j.apsb.2022.09.009 PMID: 37139426 PMC: PMC10149980
pubmed: 37139426
doi: 10.1016/j.apsb.2022.09.009
pii: S2211-3835(22)00398-7
pmc: PMC10149980
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1660-1670

Informations de copyright

© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

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Auteurs

Lu Su (L)

Department of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.
Laboratory of Macromolecular and Organic Chemistry and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, MB 5600, The Netherlands.

Kellie S Dalby (KS)

Department of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.

Hannah Luehmann (H)

Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

Sussana A Elkassih (SA)

Department of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.

Sangho Cho (S)

Department of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.

Xun He (X)

Department of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.

Lisa Detering (L)

Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

Yen-Nan Lin (YN)

Department of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.

Nari Kang (N)

Department of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.

Dennis A Moore (DA)

Bayer AG, Creve Coeur, MO 63167, USA.

Richard Laforest (R)

Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

Guorong Sun (G)

Department of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.

Yongjian Liu (Y)

Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

Karen L Wooley (KL)

Department of Chemistry, Department of Materials Science and Engineering, and Department of Chemical Engineering, Texas A&M University, College Station, TX 77842, USA.

Classifications MeSH