A proprietary black cumin oil extract (
Perceived Stress Scale
Pittsburgh Sleep Quality Index
black cumin
immunity
non-refreshing sleep
sleep quality
stress
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2023
2023
Historique:
received:
28
01
2023
accepted:
20
03
2023
medline:
4
5
2023
pubmed:
4
5
2023
entrez:
4
5
2023
Statut:
epublish
Résumé
Stress, sleep, and immunity are important interdependent factors that play critical roles in the maintenance of health. It has been established that stress can affect sleep, and the quality and duration of sleep significantly impact immunity. However, single drugs capable of targeting these factors are limited because of their multi-targeting mechanisms. The present study investigated the influence of a proprietary thymoquinone-rich black cumin oil extract (BCO-5) in modulating stress, sleep, and immunity. A randomized double-blinded placebo-controlled study was carried out on healthy volunteers with self-reported non-refreshing sleep issues ( In the BCO-5 group, 70% of the participants reported satisfaction with their sleep pattern on day 7 and 79% on day 14. Additionally, both inter- and intra- group analyses of the total PSQI scores and component scores (sleep latency, duration, efficiency, quality, and daytime dysfunction) on days 45 and 90 showed the effectiveness of BCO-5 in the improvement of sleep ( BCO-5 significantly modulated the stress-sleep-immunity axis with no side effects and restored restful sleep.
Identifiants
pubmed: 37139438
doi: 10.3389/fnut.2023.1152680
pmc: PMC10149792
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1152680Informations de copyright
Copyright © 2023 Mohan, Thomas, Mohan, Das S, Prabhakaran and Pulikkaparambil Sasidharan.
Déclaration de conflit d'intérêts
BCO-5 used in the present study is a patented black cumin extract developed by Akay Natural Ingredients, Cochin, India and registered as BlaQmax®. PP and SD were employed by Akay Natural Ingredients. JT was employed by Leads Clinical Research and Bio Services Private Limited. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Brain Behav Immun Health. 2021 Feb 28;13:100233
pubmed: 34589748
Ann N Y Acad Sci. 2010 Apr;1193:48-59
pubmed: 20398008
Braz J Med Biol Res. 2007 May;40(5):633-7
pubmed: 17464424
Physiol Rev. 2019 Jul 1;99(3):1325-1380
pubmed: 30920354
PeerJ. 2018 Mar 9;6:e4462
pubmed: 29568705
Int J Environ Res Public Health. 2020 Oct 04;17(19):
pubmed: 33020371
Innate Immun. 2012 Feb;18(1):44-54
pubmed: 21088046
Sleep Health. 2018 Jun;4(3):284-291
pubmed: 29776623
J Clin Sleep Med. 2017 Feb 15;13(2):275-281
pubmed: 27855744
Pflugers Arch. 2012 Jan;463(1):121-37
pubmed: 22071480
Handb Clin Neurol. 2011;98:229-40
pubmed: 21056190
Saudi Pharm J. 2022 Dec;30(12):1781-1790
pubmed: 36601514
J Clin Sleep Med. 2015 Aug 15;11(8):869-77
pubmed: 25845902
Neurobiol Stress. 2018 Oct 17;10:100133
pubmed: 30937343
Brain Behav Immun. 2007 Mar;21(3):308-10
pubmed: 17070668
Sleep. 2008 Mar;31(3):383-93
pubmed: 18363315
Front Psychol. 2018 Jan 26;9:37
pubmed: 29434563
Nutrients. 2021 May 24;13(6):
pubmed: 34073784
Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R504-9
pubmed: 17409265
Commun Biol. 2021 Nov 18;4(1):1304
pubmed: 34795404
Front Immunol. 2014 Oct 20;5:520
pubmed: 25368619
Brain Behav Immun. 2010 Jan;24(1):54-7
pubmed: 19520155
Endocrinol Metab Clin North Am. 2013 Jun;42(2):201-25
pubmed: 23702398
Saudi J Gastroenterol. 2015 Sep-Oct;21(5):284-9
pubmed: 26458854
Horm Metab Res. 2011 May;43(5):337-42
pubmed: 21332028
Sci Rep. 2021 Apr 6;11(1):7542
pubmed: 33824353
J Clin Sleep Med. 2016 Feb;12(2):263-6
pubmed: 26194727
Toxicol Rep. 2022 Apr 20;9:999-1007
pubmed: 36518481
Blood Cells Mol Dis. 2020 Jul;83:102437
pubmed: 32325421
Front Psychiatry. 2020 Aug 31;11:573530
pubmed: 33110414
F1000Res. 2023 Oct 18;10:1199
pubmed: 37901256
Am J Clin Exp Immunol. 2017 Dec 20;6(6):92-96
pubmed: 29348984
Eur Arch Psychiatry Clin Neurosci. 2000;250(1):16-23
pubmed: 10738860
Health Psychol Res. 2022 Aug 30;10(3):37400
pubmed: 36045942
Nutrients. 2022 Feb 03;14(3):
pubmed: 35277011
Immunopharmacol Immunotoxicol. 2011 Mar;33(1):141-5
pubmed: 20507215
Am J Physiol Regul Integr Comp Physiol. 2005 Oct;289(4):R1054-63
pubmed: 15947073
Int J Psychiatry Clin Pract. 2020 Jun;24(2):127-134
pubmed: 31913740
Transl Psychiatry. 2015 Aug 04;5:e611
pubmed: 26241349
Front Psychiatry. 2022 Oct 18;13:1034405
pubmed: 36329922
PLoS One. 2021 Mar 8;16(3):e0248117
pubmed: 33684159
Sci Pharm. 2013 Nov 05;82(1):161-70
pubmed: 24634848