Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis.
Schnurri-3
WNT signaling
osteoblast
osteoclast
rheumatoid arthritis
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
09 05 2023
09 05 2023
Historique:
medline:
8
5
2023
pubmed:
4
5
2023
entrez:
4
5
2023
Statut:
ppublish
Résumé
Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to systemic and articular bone loss by activating bone resorption and suppressing bone formation. Despite current therapeutic agents, inflammation-induced bone loss in RA continues to be a significant clinical problem due to joint deformity and lack of articular and systemic bone repair. Here, we identify the suppressor of bone formation, Schnurri-3 (SHN3), as a potential target to prevent bone loss in RA. SHN3 expression in osteoblast-lineage cells is induced by proinflammatory cytokines. Germline deletion or conditional deletion of
Identifiants
pubmed: 37141171
doi: 10.1073/pnas.2218019120
pmc: PMC10175794
doi:
Substances chimiques
beta Catenin
0
DNA-Binding Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2218019120Subventions
Organisme : NIAMS NIH HHS
ID : R21 AR079633
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR078230
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI100263
Pays : United States
Organisme : NICHD NIH HHS
ID : P01 HD080642
Pays : United States
Organisme : NIAMS NIH HHS
ID : R21 AR077557
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS076991
Pays : United States
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