Tumor tropic delivery of FU.FA@NSs using mesenchymal stem cells for synergistic chemo-photodynamic therapy of colorectal cancer.
5-Fluorouracil (5-FU)
Cerium oxide nanoparticle
Chemo-photodynamic therapy
Mesenchymal stem cell-based drug delivery
Tumor-targeting therapy
Journal
Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Titre abrégé: Colloids Surf B Biointerfaces
Pays: Netherlands
ID NLM: 9315133
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
07
03
2023
revised:
19
04
2023
accepted:
29
04
2023
medline:
2
6
2023
pubmed:
5
5
2023
entrez:
4
5
2023
Statut:
ppublish
Résumé
To overcome the limitations associated with the targeting abilities of nanotherapeutics and drug loading capacity of mesenchymal stem cells (MSCs), the present study relies on the combination of MSCs tumor tropism with the controlled release function of nano-based drug delivery platforms to achieve tumor-specific accumulation of chemotherapeutics with minimal off-target effects. 5-fluorouracil (5-FU)-containing ceria (CeNPs) coated calcium carbonate nanoparticles (CaNPs) were functionalized with folinic acid (FA) to develop drug-containing nanocomposites (Ca.FU.Ce.FA NCs). NCs were then conjugated with graphene oxide (GO) and decorated with silver nanoparticles (Ag°NPs) to form FU.FA@NS, a rationally designed drug delivery system with O
Identifiants
pubmed: 37141773
pii: S0927-7765(23)00211-4
doi: 10.1016/j.colsurfb.2023.113333
pii:
doi:
Substances chimiques
Leucovorin
Q573I9DVLP
Hydrogen Peroxide
BBX060AN9V
Silver
3M4G523W1G
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113333Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Authors declare that there is no conflict of interest with other people or organizations that could inappropriately influence or bias the content of the paper.