Neurodevelopment, vision and auditory outcomes at age 2 years in offspring of participants in the 'Women First' maternal preconception nutrition randomised controlled trial.
child development
growth
Journal
Archives of disease in childhood
ISSN: 1468-2044
Titre abrégé: Arch Dis Child
Pays: England
ID NLM: 0372434
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
21
01
2023
accepted:
10
04
2023
medline:
21
7
2023
pubmed:
5
5
2023
entrez:
4
5
2023
Statut:
ppublish
Résumé
Maternal nutrition in preconception and early pregnancy influences fetal growth. Evidence for effects of prenatal maternal nutrition on early child development (ECD) in low-income and middle-income countries is limited. To examine impact of maternal nutrition supplementation initiated prior to or during pregnancy on ECD, and to examine potential association of postnatal growth with ECD domains. Secondary analysis regarding the offspring of participants of a maternal multicountry, individually randomised trial. Rural Democratic Republic of the Congo, Guatemala, India and Pakistan. 667 offspring of Women First trial participants, aged 24 months. Maternal lipid-based nutrient supplement initiated preconceptionally (arm 1, n=217), 12 weeks gestation (arm 2, n=230) or not (arm 3, n=220); intervention stopped at delivery. The INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) cognitive, language, gross motor, fine motor, positive and negative behaviour scores; visual acuity and contrast sensitivity scores and auditory evoked response potentials (ERP). Anthropometric z-scores, family care indicators (FCI) and sociodemographic variables were examined as covariates. No significant differences were detected among the intervention arms for any INTER-NDA scores across domains, vision scores or ERP potentials. After adjusting for covariates, length-for-age z-score at 24 months (LAZ Prenatal maternal nutrition supplementation was not associated with any neurodevelopmental outcomes at age 2 years. Maternal education, family environment and LAZ NCT01883193.
Sections du résumé
BACKGROUND
Maternal nutrition in preconception and early pregnancy influences fetal growth. Evidence for effects of prenatal maternal nutrition on early child development (ECD) in low-income and middle-income countries is limited.
OBJECTIVES
To examine impact of maternal nutrition supplementation initiated prior to or during pregnancy on ECD, and to examine potential association of postnatal growth with ECD domains.
DESIGN
Secondary analysis regarding the offspring of participants of a maternal multicountry, individually randomised trial.
SETTING
Rural Democratic Republic of the Congo, Guatemala, India and Pakistan.
PARTICIPANTS
667 offspring of Women First trial participants, aged 24 months.
INTERVENTION
Maternal lipid-based nutrient supplement initiated preconceptionally (arm 1, n=217), 12 weeks gestation (arm 2, n=230) or not (arm 3, n=220); intervention stopped at delivery.
MAIN OUTCOME MEASURES
The INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) cognitive, language, gross motor, fine motor, positive and negative behaviour scores; visual acuity and contrast sensitivity scores and auditory evoked response potentials (ERP). Anthropometric z-scores, family care indicators (FCI) and sociodemographic variables were examined as covariates.
RESULTS
No significant differences were detected among the intervention arms for any INTER-NDA scores across domains, vision scores or ERP potentials. After adjusting for covariates, length-for-age z-score at 24 months (LAZ
CONCLUSIONS
Prenatal maternal nutrition supplementation was not associated with any neurodevelopmental outcomes at age 2 years. Maternal education, family environment and LAZ
TRIAL REGISTRATION NUMBER
NCT01883193.
Identifiants
pubmed: 37142335
pii: archdischild-2023-325352
doi: 10.1136/archdischild-2023-325352
pmc: PMC10423475
doi:
Banques de données
ClinicalTrials.gov
['NCT01883193']
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
622-631Subventions
Organisme : NICHD NIH HHS
ID : UG1 HD076465
Pays : United States
Organisme : NICHD NIH HHS
ID : UG1 HD078438
Pays : United States
Organisme : Medical Research Council
Pays : United Kingdom
Investigateurs
Carl L Bose
(CL)
Aura Arevalo
(A)
Gelen Gomez
(G)
Marta Lidia Aguilar
(ML)
Zahid Abbasi
(Z)
Sumera Ali
(S)
Sumaira Fatima
(S)
Deepa Metgud
(D)
Spurthi Mastiholi
(S)
Robert Kpado
(R)
Croco Gbenge
(C)
Matthieu Gbozo
(M)
Philippe Zolia
(P)
Papy Fakadanga
(P)
Joel Eay
(J)
Vanessa R Thorsten
(VR)
Dhuly Chowdhury
(D)
Abhik Das
(A)
Kristen Stolka
(K)
Omrana Pasha
(O)
Informations de copyright
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
J Nutr. 2016 Jul;146(7):1437S-44S
pubmed: 27281808
BMJ Glob Health. 2021 Apr;6(4):
pubmed: 33875519
J Glob Health. 2020 Jun;10(1):010427
pubmed: 32566165
Pediatrics. 2012 Sep;130(3):e536-46
pubmed: 22908103
J Pediatr. 2021 Feb;229:199-206.e4
pubmed: 32956698
BMC Med. 2016 Jun 16;14:90
pubmed: 27306908
Vision Res. 1994 Feb;34(4):555-60
pubmed: 8303838
Clin Neurophysiol. 2010 Apr;121(4):564-76
pubmed: 20080442
BMC Pregnancy Childbirth. 2014 Mar 20;14:111
pubmed: 24650219
Lancet. 2017 Jan 7;389(10064):77-90
pubmed: 27717614
Am J Clin Nutr. 2020 Sep 14;112(Suppl 2):777S-791S
pubmed: 32860401
Am J Clin Nutr. 2022 Jul 6;116(1):86-96
pubmed: 35681255
Am J Clin Nutr. 2021 May 8;113(5):1199-1208
pubmed: 33668050
Optom Vis Sci. 1992 Jun;69(6):427-32
pubmed: 1641223
BMJ Open. 2020 Jun 7;10(6):e035258
pubmed: 32513882
PLoS One. 2014 Nov 25;9(11):e113360
pubmed: 25423589
Future Child. 2014 Spring;24(1):99-120
pubmed: 25518705
Lancet. 2007 Jan 6;369(9555):60-70
pubmed: 17208643
Am J Clin Nutr. 2019 Feb 1;109(2):457-469
pubmed: 30721941
Am J Clin Nutr. 2016 Oct;104(4):1175-1182
pubmed: 27604769
Pediatrics. 2011 Oct;128(4):e899-906
pubmed: 21949135
Lancet. 2007 Jan 13;369(9556):145-57
pubmed: 17223478
Lancet. 2020 Feb 22;395(10224):605-658
pubmed: 32085821
Lancet. 2017 Jan 7;389(10064):103-118
pubmed: 27717610
J Nutr. 2017 Aug;147(8):1593-1601
pubmed: 28615372
J Health Popul Nutr. 2010 Feb;28(1):23-33
pubmed: 20214083