Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel K

Animals Kv1.3 Potassium Channel / chemistry Cnidarian Venoms / chemistry Sea Anemones / chemistry Peptides / chemistry Molecular Conformation Potassium Channel Blockers / pharmacology Kv1.2 Potassium Channel / metabolism

Journal

Journal of chemical information and modeling
ISSN: 1549-960X
Titre abrégé: J Chem Inf Model
Pays: United States
ID NLM: 101230060

Informations de publication

Date de publication:
22 05 2023
Historique:
medline: 23 5 2023
pubmed: 5 5 2023
entrez: 5 5 2023
Statut: ppublish

Résumé

Peptide toxins that adopt the ShK fold can inhibit the voltage-gated potassium channel K

Identifiants

DOI: 10.1021/acs.jcim.2c01237 PMID: 37143234
pubmed: 37143234
doi: 10.1021/acs.jcim.2c01237
doi:

Substances chimiques

Kv1.3 Potassium Channel 0
Cnidarian Venoms 0
Peptides 0
Potassium Channel Blockers 0
Kv1.2 Potassium Channel 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3043-3053

Auteurs

Karoline Sanches (K)

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
ARC Centre for Fragment-Based Design, Monash University, Parkville, Victoria 3052, Australia.
ORCID: 0000-0002-7259-6363

Viktor Prypoten (V)

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
ORCID: 0000-0002-2376-4455

K George Chandy (KG)

LKCMedicine-ICESing Ion Channel Platform, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore 636921, Singapore.
ORCID: 0000-0002-5237-8756

David K Chalmers (DK)

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
ORCID: 0000-0003-2366-569X

Raymond S Norton (RS)

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
ARC Centre for Fragment-Based Design, Monash University, Parkville, Victoria 3052, Australia.
ORCID: 0000-0001-8893-0584

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Interaction of the Inhibitory Peptides ShK and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques de la superfamille Shaker › Canal potassique Kv1.3 › Interaction of the Inhibitory Peptides ShK and...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de cnidaires › Interaction of the Inhibitory Peptides ShK and...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Cnidaria › Anthozoa › Anémones de mer › Interaction of the Inhibitory Peptides ShK and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Interaction of the Inhibitory Peptides ShK and...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Interaction of the Inhibitory Peptides ShK and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Inhibiteurs des canaux potassiques › Interaction of the Inhibitory Peptides ShK and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques de la superfamille Shaker › Canal potassique Kv1.2 › Interaction of the Inhibitory Peptides ShK and...