Executive functioning, behavioural, emotional, and cognitive difficulties in school-aged children prenatally exposed to methadone.
behaviour
cognition
long-term outcomes
prenatal methadone exposure
prenatal tobacco exposure
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
12
2022
accepted:
22
03
2023
medline:
5
5
2023
pubmed:
5
5
2023
entrez:
5
5
2023
Statut:
epublish
Résumé
The aim of this study was to examine executive function and emotional and behavioural difficulties of children aged between 8 and 10 years who had been prenatally exposed to methadone, compared to non-exposed peers. Prospective study: third follow-up of an original cohort of 153 children born to methadone-maintained opioid-dependent mothers 2008-2010: previous investigations were at 1-3 days and at 6-7 months of age. Carers completed the Strength and Difficulties Questionnaire (SDQ) and the Behaviour Rating Inventory of Executive Function, Second Edition (BRIEF®2). Results were compared between exposed and non-exposed groups. Carers of 33 of 144 traceable children completed the measures. SDQ responses showed no group differences on subscales of emotional symptoms, conduct problems, or peer relationship problems. A marginally higher proportion of exposed children had a high or very high hyperactivity subscale score. Exposed children scored significantly higher on BRIEF®2 behavioural, emotional, and cognitive regulation indices, and on the global executive composite. After controlling for potentially confounding higher reported maternal tobacco use in the exposed group This study supports evidence that methadone exposure
Identifiants
pubmed: 37144152
doi: 10.3389/fped.2023.1118634
pmc: PMC10151701
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1118634Informations de copyright
© 2023 Spowart, Reilly, Mactier and Hamilton.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Dev Med Child Neurol. 2021 Sep;63(9):1114-1122
pubmed: 33462809
Arch Dis Child. 2003 Dec;88(12):1086-90
pubmed: 14670776
Cochrane Database Syst Rev. 2020 Nov 9;11:CD006318
pubmed: 33165953
Br J Psychiatry. 2000 Dec;177:534-9
pubmed: 11102329
Arch Dis Child. 2021 Jan;106(1):80-82
pubmed: 31836633
Pediatrics. 2020 Nov;146(5):
pubmed: 33106341
Eur Child Adolesc Psychiatry. 2003 Jan;12(1):1-8
pubmed: 12601558
Drug Alcohol Depend. 2017 Jul 1;176:169-175
pubmed: 28544995
J Adolesc Health. 2009 Jul;45(1):55-62
pubmed: 19541250
BMC Psychiatry. 2015 Jun 25;15:134
pubmed: 26108949
Neurotoxicol Teratol. 2003 Jul-Aug;25(4):427-36
pubmed: 12798960
Pediatr Res. 2015 Sep;78(3):330-5
pubmed: 25978800
Br J Ophthalmol. 2014 Feb;98(2):238-45
pubmed: 24246372
J Child Psychol Psychiatry. 1997 Jul;38(5):581-6
pubmed: 9255702
Dev Med Child Neurol. 2019 Jul;61(7):750-760
pubmed: 30511742
Acad Pediatr. 2020 Apr;20(3):308-318
pubmed: 31734383
PLoS One. 2016 Jun 23;11(6):e0158054
pubmed: 27336798
Child Neuropsychol. 2017 Feb;23(2):159-187
pubmed: 26471942
J Am Acad Child Adolesc Psychiatry. 2009 Apr;48(4):400-403
pubmed: 19242383
Early Hum Dev. 2015 Jan;91(1):19-21
pubmed: 25460252
J Addict Med. 2020 Mar/Apr;14(2S Suppl 1):1-91
pubmed: 32511106
Clin Pediatr (Phila). 1975 Jun;14(6):592-4
pubmed: 1126108
Popul Health Manag. 2019 Feb;22(1):19-24
pubmed: 29893624
Pediatr Res. 2022 Aug 30;:
pubmed: 36042329
Early Hum Dev. 2020 Apr;143:104997
pubmed: 32146140
Ther Drug Monit. 2008 Apr;30(2):239-45
pubmed: 18367988
Reprod Toxicol. 2018 Mar;76:63-70
pubmed: 29294364
Child Neuropsychol. 2000 Sep;6(3):235-8
pubmed: 11419452
Addiction. 2014 Mar;109(3):482-8
pubmed: 24321028
Arch Dis Child. 2008 Sep;93(9):784-6
pubmed: 18305073