Mediators of the association between childhood trauma and pain sensitivity in adulthood: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network analysis.
Journal
Pain
ISSN: 1872-6623
Titre abrégé: Pain
Pays: United States
ID NLM: 7508686
Informations de publication
Date de publication:
01 09 2023
01 09 2023
Historique:
received:
29
11
2022
accepted:
13
02
2023
pmc-release:
01
09
2024
medline:
21
8
2023
pubmed:
5
5
2023
entrez:
5
5
2023
Statut:
ppublish
Résumé
Urologic chronic pelvic pain syndrome (UCPPS) is a complex, debilitating condition in which patients often report nonpelvic pain in addition to localized pelvic pain. Understanding differential predictors of pelvic pain only vs widespread pain may provide novel pathways for intervention. This study leveraged baseline data from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network's Symptom Pattern Study to investigate the impact of childhood sexual and nonsexual violent trauma on pelvic and nonpelvic pain sensitivity among adult patients with UCPPS, as well as potential mediators of this association. Study participants who met inclusion criteria for UCPPS completed questionnaires assessing childhood and recent trauma, affective distress, cognitive dysfunction, and generalized sensory sensitivity. Experimental pain sensitivity was also evaluated using standardized pressure pain applied to the pubic region and the arm. Bivariate analyses showed that childhood violent trauma was associated with more nonviolent childhood trauma, more recent trauma, poorer adult functioning, and greater pain sensitivity at the pubic region, but not pain sensitivity at the arm. Path analysis suggested that childhood violent trauma was indirectly associated with pain sensitivity at both sites and that this indirect association was primarily mediated by generalized sensory sensitivity. More experiences of recent trauma also contributed to these indirect effects. The findings suggest that, among participants with UCPPS, childhood violent trauma may be associated with heightened pain sensitivity to the extent that trauma history is associated with a subsequent increase in generalized sensory sensitivity.
Identifiants
pubmed: 37144687
doi: 10.1097/j.pain.0000000000002895
pii: 00006396-990000000-00296
pmc: PMC10440258
mid: NIHMS1876840
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1995-2008Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK082345
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082315
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082316
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082344
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082333
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK082316
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK082333
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082325
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002240
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082370
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082342
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH126079
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH115882
Pays : United States
Informations de copyright
Copyright © 2023 International Association for the Study of Pain.
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