The dark kinase STK32A regulates hair cell planar polarity opposite of EMX2 in the developing mouse inner ear.
EMX2
GPR156
STK32A
cell biology
developmental biology
hair cell
mouse
planar cell polarity
vestibular
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
05 05 2023
05 05 2023
Historique:
received:
14
11
2022
accepted:
03
05
2023
medline:
24
5
2023
pubmed:
5
5
2023
entrez:
5
5
2023
Statut:
epublish
Résumé
The vestibular maculae of the inner ear contain sensory receptor hair cells that detect linear acceleration and contribute to equilibrioception to coordinate posture and ambulatory movements. These hair cells are divided between two groups, separated by a line of polarity reversal (LPR), with oppositely oriented planar-polarized stereociliary bundles that detect motion in opposite directions. The transcription factor EMX2 is known to establish this planar polarized organization in mouse by regulating the distribution of the transmembrane receptor GPR156 at hair cell boundaries in one group of cells. However, the genes regulated by EMX2 in this context were previously not known. Using mouse as a model, we have identified the serine threonine kinase STK32A as a downstream effector negatively regulated by EMX2.
Identifiants
pubmed: 37144879
doi: 10.7554/eLife.84910
pii: 84910
pmc: PMC10202454
doi:
pii:
Substances chimiques
Transcription Factors
0
Stk32a protein, mouse
0
Banques de données
GEO
['GSE218746']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC018304
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC015242
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC013066
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007491
Pays : United States
Informations de copyright
© 2023, Jia, Ratzan et al.
Déclaration de conflit d'intérêts
SJ, ER, EG, RA, LH, BT, MD No competing interests declared
Références
Mol Cell. 2020 Aug 6;79(3):504-520.e9
pubmed: 32707033
Nat Commun. 2015 Oct 15;6:8557
pubmed: 26469390
Development. 2018 Jun 26;145(12):
pubmed: 29945988
Development. 2016 Nov 1;143(21):3926-3932
pubmed: 27660326
Curr Top Dev Biol. 2020;136:377-407
pubmed: 31959296
J Neurosci. 2018 Oct 17;38(42):9105-9121
pubmed: 30143575
Dev Cell. 2017 Mar 13;40(5):439-452.e4
pubmed: 28292423
Cancers (Basel). 2021 Mar 10;13(6):
pubmed: 33801837
Dev Biol. 2010 Apr 15;340(2):547-56
pubmed: 20152827
Nucleic Acids Res. 2021 Jan 8;49(D1):D480-D489
pubmed: 33237286
Neurosci Lett. 2019 Sep 14;709:134373
pubmed: 31295539
Cell Tissue Res. 2010 May;340(2):303-21
pubmed: 20424840
Nature. 2007 Mar 8;446(7132):153-8
pubmed: 17344846
Nat Genet. 2005 Oct;37(10):1135-40
pubmed: 16170314
Nat Commun. 2021 May 17;12(1):2861
pubmed: 34001891
Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1488-93
pubmed: 20080638
J Neurosci. 2006 Feb 22;26(8):2147-56
pubmed: 16495441
J Cell Biol. 2010 Jul 12;190(1):9-20
pubmed: 20624897
Hum Gene Ther Methods. 2012 Feb;23(1):18-28
pubmed: 22428977
Semin Cell Dev Biol. 2013 May;24(5):490-8
pubmed: 23507521
J Neurosci. 2007 Mar 21;27(12):3139-47
pubmed: 17376975
Nat Commun. 2022 Oct 24;13(1):6330
pubmed: 36280667
Semin Cell Dev Biol. 2009 Oct;20(8):986-97
pubmed: 19761865
Nucleic Acids Res. 2021 Jan 8;49(D1):D529-D535
pubmed: 33079988
Science. 2017 May 26;356(6340):
pubmed: 28495876
Elife. 2017 Mar 07;6:
pubmed: 28266911
Cell. 2009 Oct 2;139(1):33-44
pubmed: 19804752
Curr Biol. 2020 Mar 23;30(6):1142-1151.e6
pubmed: 32109392
J Neurosci. 2009 Dec 16;29(50):15859-69
pubmed: 20016102
Development. 2013 Apr;140(8):1785-95
pubmed: 23533177
Dev Biol. 2018 May 01;437(1):17-26
pubmed: 29510119
Semin Cell Dev Biol. 2018 Sep;81:78-87
pubmed: 29107170
Cell Rep. 2021 Jul 13;36(2):109358
pubmed: 34260939
Mol Cancer Ther. 2009 Aug;8(8):2103-9
pubmed: 19671746
Front Neurosci. 2021 Oct 18;15:742391
pubmed: 34733133
Curr Biol. 2003 Jul 1;13(13):1129-33
pubmed: 12842012
Neuron. 2004 Aug 5;43(3):359-72
pubmed: 15294144
Nature. 2003 May 8;423(6936):173-7
pubmed: 12724779
PLoS One. 2012;7(2):e31988
pubmed: 22363783
Nat Methods. 2021 Aug;18(8):843-844
pubmed: 34172972
J Neurosci. 2005 May 25;25(21):5097-108
pubmed: 15917450
PLoS Biol. 2018 Jul 19;16(7):e2004404
pubmed: 30024872
Nucleic Acids Res. 2012 Aug;40(14):6461-76
pubmed: 22495934
Front Neurosci. 2021 Nov 01;15:750596
pubmed: 34790090
Curr Biol. 2019 Mar 18;29(6):921-934.e4
pubmed: 30827920
Nature. 1989 Oct 5;341(6241):397-404
pubmed: 2677742
Mol Cell Neurosci. 2006 Oct;33(2):136-49
pubmed: 16919471
Dev Biol. 2017 Mar 15;423(2):126-137
pubmed: 28159525
Hear Res. 2011 Oct;280(1-2):21-9
pubmed: 21620939
Nat Commun. 2019 Aug 19;10(1):3733
pubmed: 31427575
Nat Protoc. 2019 Feb;14(2):379-414
pubmed: 30626963