Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study.

Rats Male Animals Cytochrome P-450 CYP1A2 / metabolism Pilot Projects ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism Jejunum / metabolism Rats, Sprague-Dawley Cytochrome P-450 Enzyme System / metabolism Liver / metabolism Cytochrome P-450 CYP3A / metabolism Cytochrome P450 Family 2 / metabolism Aryl Hydrocarbon Hydroxylases / metabolism Steroid 16-alpha-Hydroxylase / metabolism
Coptisine Florfenicol P-glycoprotein cytochrome P450 pharmacokinetics

Journal

Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665

Informations de publication

Date de publication:
Mar 2023
Historique:
medline: 7 6 2023
pubmed: 5 5 2023
entrez: 5 5 2023
Statut: ppublish

Résumé

Coptisine (COP) is the main active ingredient of

Identifiants

DOI: 10.1080/00498254.2023.2211135 PMID: 37144948
pubmed: 37144948
doi: 10.1080/00498254.2023.2211135
doi:

Substances chimiques

Cytochrome P-450 CYP1A2 EC 1.14.14.1
ATP Binding Cassette Transporter, Subfamily B, Member 1 0
coptisine 0GCL71VN14
florfenicol 9J97307Y1H
Cytochrome P-450 Enzyme System 9035-51-2
Cytochrome P-450 CYP3A EC 1.14.14.1
CYP2C11 protein, rat EC 1.14.14.1
Cytochrome P450 Family 2 EC 1.14.14.1
Aryl Hydrocarbon Hydroxylases EC 1.14.14.1
Steroid 16-alpha-Hydroxylase EC 1.14.14.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

207-214

Auteurs

Si-Cong Li (SC)

Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.
Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.

Min Zhang (M)

Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.
Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.

Bin Wang (B)

Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.
Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.

Xu-Ting Li (XT)

Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.
Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.

Ge Liang (G)

Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.
Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Coptisine modulates the pharmacokinetics of...
questionsmedicales.fr › Eucaryotes › Animaux › Coptisine modulates the pharmacokinetics of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-1 de cytochromes P450 › Cytochrome P-450 CYP1A2 › Coptisine modulates the pharmacokinetics of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Projets pilotes › Coptisine modulates the pharmacokinetics of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques ATP-dépendants › Sous-famille B de transporteurs à cassette liant l'ATP › Glycoprotéine P › Coptisine modulates the pharmacokinetics of...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Jéjunum › Coptisine modulates the pharmacokinetics of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Coptisine modulates the pharmacokinetics of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Coptisine modulates the pharmacokinetics of...
questionsmedicales.fr › Système digestif › Foie › Coptisine modulates the pharmacokinetics of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-3 de cytochromes P450 › Cytochrome P-450 CYP3A › Coptisine modulates the pharmacokinetics of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-2 de cytochromes P450 › Coptisine modulates the pharmacokinetics of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Aryl hydrocarbon hydroxylases › Coptisine modulates the pharmacokinetics of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Steroid hydroxylases › Steroid 16-alpha-hydroxylase › Coptisine modulates the pharmacokinetics of...