Design, synthesis, and docking of novel thiazolidine-2,4-dione multitarget scaffold as new approach for cancer treatment.

Humans Structure-Activity Relationship Cell Line, Tumor Thiazolidines / pharmacology Vascular Endothelial Growth Factor Receptor-2 / metabolism ErbB Receptors / metabolism Antineoplastic Agents Protein Kinase Inhibitors / pharmacology Molecular Docking Simulation Lung Neoplasms Mutation Drug Screening Assays, Antitumor Cell Proliferation Molecular Structure
4-dione anticancer agents dual inhibitors of VEGFR-2/EGFRT790M molecular docking thiazolidine-2

Journal

Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167

Informations de publication

Date de publication:
Jul 2023
Historique:
revised: 17 04 2023
received: 07 03 2023
accepted: 18 04 2023
medline: 6 7 2023
pubmed: 6 5 2023
entrez: 6 5 2023
Statut: ppublish

Résumé

Novel thiazolidine-2,4-diones have been developed and estimated as conjoint inhibitors of EGFR

Identifiants

DOI: 10.1002/ardp.202300137 PMID: 37147779
pubmed: 37147779
doi: 10.1002/ardp.202300137
doi:

Substances chimiques

Thiazolidines 0
Vascular Endothelial Growth Factor Receptor-2 EC 2.7.10.1
ErbB Receptors EC 2.7.10.1
Antineoplastic Agents 0
thiazolidine-2,4-dione 0
Protein Kinase Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2300137

Subventions

Organisme : Princess Nourah bint Abdulrahman University

Informations de copyright

© 2023 Deutsche Pharmazeutische Gesellschaft.

Références

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Auteurs

Noura S Hanafy (NS)

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt.

Nada A A M Aziz (NAAM)

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt.

Sanadelaslam S A El-Hddad (SSA)

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Omar Almukhtar University, Libya.

Mohamed A Abdelgawad (MA)

Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

Mohammed M Ghoneim (MM)

Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi Arabia.
Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

Amal F Dawood (AF)

Department of Basic Medical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.

Samy Mohamady (S)

Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.

Khaled El-Adl (K)

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt.
Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
ORCID: 0000-0002-8922-9770

Sahar Ahmed (S)

Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia.
Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

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