Cytomegalovirus and Cardiovascular Disease: A Hypothetical Role for Viral G-Protein-Coupled Receptors in Hypertension.
US28
blood pressure
cardiovascular diseases
chemokine receptors
cytomegalovirus
hypertension
viral G-protein-coupled receptors
Journal
American journal of hypertension
ISSN: 1941-7225
Titre abrégé: Am J Hypertens
Pays: United States
ID NLM: 8803676
Informations de publication
Date de publication:
05 08 2023
05 08 2023
Historique:
received:
17
04
2023
accepted:
02
05
2023
pmc-release:
06
05
2024
medline:
7
8
2023
pubmed:
6
5
2023
entrez:
6
5
2023
Statut:
ppublish
Résumé
Cytomegalovirus (CMV) is a member of the β-herpesviruses and is ubiquitous, infecting 50%-99% of the human population depending on ethnic and socioeconomic conditions. CMV establishes lifelong, latent infections in their host. Spontaneous reactivation of CMV is usually asymptomatic, but reactivation events in immunocompromised or immunosuppressed individuals can lead to severe morbidity and mortality. Moreover, herpesvirus infections have been associated with several cardiovascular and post-transplant diseases (stroke, atherosclerosis, post-transplant vasculopathy, and hypertension). Herpesviruses, including CMV, encode viral G-protein-coupled receptors (vGPCRs) that alter the host cell by hijacking signaling pathways that play important roles in the viral life cycle and these cardiovascular diseases. In this brief review, we discuss the pharmacology and signaling properties of these vGPCRs, and their contribution to hypertension. Overall, these vGPCRs can be considered attractive targets moving forward in the development of novel hypertensive therapies.
Identifiants
pubmed: 37148218
pii: 7155859
doi: 10.1093/ajh/hpad045
pmc: PMC10403975
doi:
Substances chimiques
Receptors, G-Protein-Coupled
0
Types de publication
Review
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
471-480Subventions
Organisme : NIH HHS
ID : DK132948
Pays : United States
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Med Sci Monit. 2014 Dec 02;20:2508-19
pubmed: 25448630
Viral Immunol. 2023 Jan;36(1):13-24
pubmed: 36622943
Sci Rep. 2020 Feb 10;10(1):2252
pubmed: 32041970
N Engl J Med. 2006 Feb 9;354(6):610-21
pubmed: 16467548
J Biol Chem. 2009 Nov 6;284(45):31270-9
pubmed: 19758998
Stroke. 1999 Feb;30(2):299-305
pubmed: 9933263
Am J Epidemiol. 2010 Aug 15;172(4):363-71
pubmed: 20660122
J Med Virol. 2023 Jan;95(1):e28352
pubmed: 36437481
J Crit Care. 2015 Apr;30(2):276-81
pubmed: 25457114
PLoS Pathog. 2009 May;5(5):e1000427
pubmed: 19436702
Sci Rep. 2018 Jun 5;8(1):8598
pubmed: 29872089
Biomedicines. 2022 Oct 19;10(10):
pubmed: 36289895
Geriatr Gerontol Int. 2016 Jan;16(1):21-7
pubmed: 25496508
Virology. 2000 Jul 5;272(2):357-65
pubmed: 10873779
Cardiovasc Res. 2009 Jan 1;81(1):11-9
pubmed: 18818214
Circulation. 1999 Jul 6;100(1):61-6
pubmed: 10393682
Exp Biol Med (Maywood). 2015 Sep;240(9):1223-34
pubmed: 25585624
Am J Med. 2020 Jan;133(1):133-142
pubmed: 31295440
Circ Res. 2021 Apr 2;128(7):993-1020
pubmed: 33793335
PLoS Pathog. 2011 Nov;7(11):e1002366
pubmed: 22114552
Mol Pharmacol. 2005 Feb;67(2):460-9
pubmed: 15509716
J Hypertens. 2006 Jul;24(7):1307-18
pubmed: 16794480
Biochem Pharmacol. 2022 Nov;205:115256
pubmed: 36185001
Int Immunopharmacol. 2021 Dec;101(Pt B):107598
pubmed: 34233864
mBio. 2021 Jun 29;12(3):e0022721
pubmed: 34061599
Curr Top Microbiol Immunol. 2008;325:417-70
pubmed: 18637519
J Clin Med. 2022 Jul 01;11(13):
pubmed: 35807114
Arch Neurol. 2010 Jan;67(1):33-8
pubmed: 19901154
PLoS Pathog. 2016 Sep 08;12(9):e1005832
pubmed: 27606804
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2001 Dec;15(4):377-9
pubmed: 11986733
Rev Med Virol. 2009 Jan;19(1):47-56
pubmed: 19035529
Am J Physiol Renal Physiol. 2020 Apr 1;318(4):F982-F993
pubmed: 32150444
Nature. 2021 Nov;599(7883):125-130
pubmed: 34671159
PLoS One. 2012;7(7):e39760
pubmed: 22768311
Eur Heart J. 2022 May 14;43(19):1799-1808
pubmed: 35567558
Nat Rev Clin Oncol. 2022 Apr;19(4):237-253
pubmed: 34997230
Nat Rev Gastroenterol Hepatol. 2021 Sep;18(9):630-647
pubmed: 33976393
Hypertension. 1997 Dec;30(6):1397-402
pubmed: 9403559
Curr Opin Pharmacol. 2010 Feb;10(1):6-13
pubmed: 19962942
Circ Res. 1998 Nov 2;83(9):952-9
pubmed: 9797345
J Infect Dis. 2014 May 1;209(9):1382-92
pubmed: 24203779
Circulation. 2004 Feb 3;109(4):500-5
pubmed: 14732750
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1999 Mar;13(1):23-6
pubmed: 12759946
J Am Heart Assoc. 2017 Aug 28;6(9):
pubmed: 28847915
Mol Med. 2014 Oct 13;20:435-47
pubmed: 25032954
J Med Virol. 2016 May;88(5):852-8
pubmed: 26399974
Am J Hypertens. 2013 Sep;26(9):1140-7
pubmed: 23744497
Cell Death Dis. 2022 Feb 17;13(2):158
pubmed: 35177591
J Virol. 2005 Feb;79(4):2211-20
pubmed: 15681423
Trends Pharmacol Sci. 2009 Apr;30(4):182-7
pubmed: 19269046
Circ Res. 2021 Apr 2;128(7):969-992
pubmed: 33793333
Clin Exp Immunol. 2015 Feb;179(2):173-87
pubmed: 25352024
Curr Opin Hematol. 2018 Jan;25(1):44-51
pubmed: 28914666
Br J Pharmacol. 1996 Oct;119(4):637-46
pubmed: 8904636
J Infect Dis. 2022 Apr 1;225(7):1179-1188
pubmed: 34279656
Cell Mol Immunol. 2018 Apr;15(4):335-345
pubmed: 29375123
J Intern Med. 2006 Mar;259(3):219-46
pubmed: 16476101
Brain Behav Immun. 2014 May;38:133-41
pubmed: 24472683
Hypertension. 2000 Sep;36(3):360-3
pubmed: 10988265
Pharmacol Ther. 2021 Jul;223:107799
pubmed: 33359600
Adv Clin Exp Med. 2014 May-Jun;23(3):319-25
pubmed: 24979502
Circulation. 2003 Aug 12;108(6):678-83
pubmed: 12900349
Clin Vaccine Immunol. 2012 May;19(5):772-9
pubmed: 22398244
Circulation. 2003 Jan 21;107(2):251-7
pubmed: 12538424
Front Microbiol. 2019 Feb 07;10:16
pubmed: 30792698
J Gen Virol. 2004 Nov;85(Pt 11):3337-3341
pubmed: 15483249
J Biol Chem. 1991 May 25;266(15):9912-8
pubmed: 2033076
J Interferon Cytokine Res. 2009 Jun;29(6):313-26
pubmed: 19441883
Circ Res. 2001 Dec 7;89(12):1224-30
pubmed: 11739289
Brain Behav Immun. 2015 Nov;50:52-57
pubmed: 26116982
Acta Biochim Biophys Sin (Shanghai). 2020 Apr 20;52(4):339-353
pubmed: 32253424
Brain Behav Immun. 2019 Aug;80:266-274
pubmed: 30885843
Postgrad Med J. 2022 Mar;98(1157):172-176
pubmed: 33541928
FEBS J. 2018 Aug;285(16):2944-2971
pubmed: 29637711
J Immunol. 2014 Jul 1;193(1):400-11
pubmed: 24890717
Br J Pharmacol. 2012 Mar;165(6):1617-1643
pubmed: 21699506
Arthritis Res Ther. 2018 Aug 29;20(1):194
pubmed: 30157919
Front Immunol. 2019 Dec 13;10:2759
pubmed: 31921102
J Med Virol. 2017 Dec;89(12):2196-2206
pubmed: 28513970
Circ Res. 2004 May 14;94(9):1203-10
pubmed: 15059935
Nat Immunol. 2001 Feb;2(2):108-15
pubmed: 11175802
Theranostics. 2021 Mar 31;11(12):5728-5741
pubmed: 33897878
Int J Mol Sci. 2019 Mar 22;20(6):
pubmed: 30909422
J Immunol. 1989 Mar 15;142(6):1956-62
pubmed: 2921521
J Interferon Cytokine Res. 2014 Oct;34(10):778-86
pubmed: 24702175
J Biol Chem. 2007 Oct 12;282(41):30062-9
pubmed: 17715128
Cardiovasc Res. 2005 Jul 1;67(1):151-60
pubmed: 15949479
Circulation. 2011 Jul 12;124(2):175-84
pubmed: 21690488
Annu Rev Pharmacol Toxicol. 2002;42:469-99
pubmed: 11807180
Front Pharmacol. 2015 Mar 09;6:40
pubmed: 25805993
J Am Heart Assoc. 2017 Jul 6;6(7):
pubmed: 28684641
Wien Klin Wochenschr. 2016 Aug;128(15-16):586-91
pubmed: 26980213
Acta Med Scand. 1982;212(6):375-7
pubmed: 6297261
Pharmacol Rev. 2021 Apr;73(2):828-846
pubmed: 33692148