Ketogenic diet ameliorates autism spectrum disorders-like behaviors via reduced inflammatory factors and microbiota remodeling in BTBR T

Mice Animals Autism Spectrum Disorder / metabolism Mice, Inbred C57BL Diet, Ketogenic Brain / metabolism Microbiota Disease Models, Animal Mice, Inbred Strains
Inflammatory factors Microbial community diversity Oxidative stress Three-chamber sociability Tumor necrosis factor alpha

Journal

Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712

Informations de publication

Date de publication:
08 2023
Historique:
received: 14 03 2023
revised: 20 04 2023
accepted: 03 05 2023
medline: 13 6 2023
pubmed: 7 5 2023
entrez: 6 5 2023
Statut: ppublish

Résumé

Autism Spectrum Disorder (ASD) is increasing, but its complete etiology is still lacking. Recently, application of ketogenic diet (KD) has shown to reduce abnormal behaviors while improving psychological/sociological status in neurodegenerative diseases. However, KD role on ASD and underlying mechanism remains unknown. In this work, KD administered to BTBR T

Identifiants

DOI: 10.1016/j.expneurol.2023.114432 PMID: 37149279
pubmed: 37149279
pii: S0014-4886(23)00117-6
doi: 10.1016/j.expneurol.2023.114432
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

114432

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that there is no conflict of interests that could be perceived as prejudicing the impartiality of the research reported.

Auteurs

Ilaria Olivito (I)

Comparative Neuroanatomy Laboratory, Department of Biology, Ecology and Earth Sciences (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, Arcavacata di Rende, 87036 Cosenza, Italy.

Ennio Avolio (E)

Comparative Neuroanatomy Laboratory, Department of Biology, Ecology and Earth Sciences (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, Arcavacata di Rende, 87036 Cosenza, Italy; Health Center s.r.l., 87100 Cosenza, Italy.

Damiana Minervini (D)

Comparative Neuroanatomy Laboratory, Department of Biology, Ecology and Earth Sciences (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, Arcavacata di Rende, 87036 Cosenza, Italy.

Teresa Soda (T)

Department of Health Science, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.

Carmine Rocca (C)

Cellular and Molecular Cardio-Vascular Patho-Physiology, Department of Biology, Ecology and Earth Sciences (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, Arcavacata di Rende, 87036 Cosenza, Italy.

Tommaso Angelone (T)

Cellular and Molecular Cardio-Vascular Patho-Physiology, Department of Biology, Ecology and Earth Sciences (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, Arcavacata di Rende, 87036 Cosenza, Italy.

Francesco Salvatore Iaquinta (FS)

Rheumatology Research Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, Edificio delle Bioscienze-Viale Europa, 88100 Catanzaro, Italy.

Dina Bellizzi (D)

Genetics and Microbiology Laboratory, Department of Biology, Ecology and Earth Sciences (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, Arcavacata di Rende, 87036 Cosenza, Italy.

Francesco De Rango (F)

Genetics, Department of Biology, Ecology and Earth Sciences (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, Arcavacata di Rende, 87036 Cosenza, Italy.

Rosalinda Bruno (R)

Department of Pharmacy and Science of Health and Nutrition, Edificio Polifunzionale University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy.

Loredana De Bartolo (L)

Institute of Membrane Technology, National Research Council of Italy, ITM-CNR, c/o University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy.

Raffaella Alò (R)

Comparative Neuroanatomy Laboratory, Department of Biology, Ecology and Earth Sciences (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, Arcavacata di Rende, 87036 Cosenza, Italy.

Marcello Canonaco (M)

Comparative Neuroanatomy Laboratory, Department of Biology, Ecology and Earth Sciences (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, Arcavacata di Rende, 87036 Cosenza, Italy.

Rosa Maria Facciolo (RM)

Comparative Neuroanatomy Laboratory, Department of Biology, Ecology and Earth Sciences (DiBEST), University of Calabria, Ponte Pietro Bucci 4B, Arcavacata di Rende, 87036 Cosenza, Italy. Electronic address: rm.facciolo@unical.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Ketogenic diet ameliorates autism spectrum...
questionsmedicales.fr › Eucaryotes › Animaux › Ketogenic diet ameliorates autism spectrum...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Ketogenic diet ameliorates autism spectrum...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Ketogenic diet ameliorates autism spectrum...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Régime pauvre en glucides › Régime cétogène › Ketogenic diet ameliorates autism spectrum...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Ketogenic diet ameliorates autism spectrum...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Ketogenic diet ameliorates autism spectrum...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Ketogenic diet ameliorates autism spectrum...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Ketogenic diet ameliorates autism spectrum...