Infantile hemangioma models: is the needle in a haystack?
3D microtumor
Infantile hemangioma
Pathogenesis
Transplantation model
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
06 05 2023
06 05 2023
Historique:
received:
31
03
2023
accepted:
20
04
2023
medline:
8
5
2023
pubmed:
7
5
2023
entrez:
6
5
2023
Statut:
epublish
Résumé
Infantile hemangioma (IH) is the most prevalent benign vascular tumor in infants, with distinct disease stages and durations. Despite the fact that the majority of IHs can regress spontaneously, a small percentage can cause disfigurement or even be fatal. The mechanisms underlying the development of IH have not been fully elucidated. Establishing stable and reliable IH models provides a standardized experimental platform for elucidating its pathogenesis, thereby facilitating the development of new drugs and the identification of effective treatments. Common IH models include the cell suspension implantation model, the viral gene transfer model, the tissue block transplantation model, and the most recent three-dimensional (3D) microtumor model. This article summarizes the research progress and clinical utility of various IH models, as well as the benefits and drawbacks of each. Researchers should select distinct IH models based on their individual research objectives to achieve their anticipated experimental objectives, thereby increasing the clinical relevance of their findings.
Identifiants
pubmed: 37149592
doi: 10.1186/s12967-023-04144-0
pii: 10.1186/s12967-023-04144-0
pmc: PMC10163722
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
308Informations de copyright
© 2023. The Author(s).
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