A comparative investigation of catalytic mechanism and domain between catechol-O-methyltransferase isoforms by isomeric shikonin and alkannin.

Rats Humans Animals Catechol O-Methyltransferase / chemistry Molecular Docking Simulation Protein Isoforms
COMTs Isomers Ligand-receptor interaction

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
01 Jul 2023
Historique:
received: 03 01 2023
revised: 12 04 2023
accepted: 02 05 2023
medline: 19 6 2023
pubmed: 8 5 2023
entrez: 7 5 2023
Statut: ppublish

Résumé

The differences in catalytic mechanism and domain between the soluble (S-COMT) and membrane-bound catechol-O-methyltransferase (MB-COMT) are poorly documented due to the unavailable crystal structure of MB-COMT. Considering the enzymatic nature of S-COMT and MB-COMT, the challenge could be solvable by probing the interactions between the enzymes with the ligands with minor differences in structures. Herein, isomeric shikonin and alkannin bearing a R/S -OH group in side chain at the C2 position were used for domain profiling of COMTs. Human and rat liver-derived COMTs showed the differences in inhibitory response (human's IC

Identifiants

DOI: 10.1016/j.ijbiomac.2023.124758 PMID: 37150367
pubmed: 37150367
pii: S0141-8130(23)01652-5
doi: 10.1016/j.ijbiomac.2023.124758
pii:
doi:

Substances chimiques

shikonin 3IK6592UBW
Catechol O-Methyltransferase EC 2.1.1.6
alkannin 075CRZ9995
Protein Isoforms 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

124758

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no competing financial interest.

Auteurs

Sicheng Liang (S)

Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; Department of Dermatology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; The Public Platform of Advanced Detecting Instruments, Public Center of Experimental Technology, Southwest Medical University, Luzhou 646000, China; Human Microecology and Precision Diagnosis and Treatment of Luzhou Key Laboratory, Luzhou 646000, China; Cardiovascular and Metabolic Diseases of Sichuan Key Laboratory, Luzhou 646000, China.

Wenjing Zhao (W)

Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.

Yonglan Chen (Y)

Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.

Hua Lin (H)

Technology Center of Chengdu Customs, Chengdu, China.

Wei Zhang (W)

Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.

Mingming Deng (M)

Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.

Lu Fu (L)

The Public Platform of Advanced Detecting Instruments, Public Center of Experimental Technology, Southwest Medical University, Luzhou 646000, China.

Xiaolin Zhong (X)

Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.

Su Zeng (S)

Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang University, Hangzhou, China.

Bing He (B)

The Public Platform of Advanced Detecting Instruments, Public Center of Experimental Technology, Southwest Medical University, Luzhou 646000, China.

Xiaoyi Qi (X)

Department of Dermatology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China. Electronic address: 7xiao1@163.com.

Muhan Lü (M)

Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; Human Microecology and Precision Diagnosis and Treatment of Luzhou Key Laboratory, Luzhou 646000, China; Cardiovascular and Metabolic Diseases of Sichuan Key Laboratory, Luzhou 646000, China. Electronic address: lvmuhan@swmu.edu.cn.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › A comparative investigation of catalytic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A comparative investigation of catalytic...
questionsmedicales.fr › Eucaryotes › Animaux › A comparative investigation of catalytic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Catechol O-methyltransferase › A comparative investigation of catalytic...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › A comparative investigation of catalytic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › A comparative investigation of catalytic...