Biochemometry identifies suppressors of pro-inflammatory gene expression in Pterocarpus santalinus heartwood.
Biochemometry
CX3CL1
ELINA
Endothelial cells
Fabaceae
Inflammation
Isoflavonoids
Pterocarpans
Pterocarpus santalinus
Red sandalwood
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
22
10
2022
revised:
04
05
2023
accepted:
04
05
2023
medline:
15
6
2023
pubmed:
8
5
2023
entrez:
7
5
2023
Statut:
ppublish
Résumé
The heartwood extract of the Ayurvedic medicinal plant Pterocarpus santalinus L. f. has previously been shown to significantly suppress the expression of CX3CL1 and other pro-inflammatory molecules in IL-1-stimulated human endothelial cells. Here, we identify the pigment-depleted extract PSD as the most promising yet still complex source of metabolites acting as an inhibitor of CX3CL1 gene expression. For the target-oriented identification of the constituents contributing to the observed in vitro anti-inflammatory effect of PSD, the biochemometric approach ELINA (Eliciting Nature's Activities) was applied. ELINA relies on the deconvolution of complex mixtures by generating microfractions with quantitative variances of constituents over several consecutive fractions. Therefore, PSD was separated into 35 microfractions by means of flash chromatography. Their
Identifiants
pubmed: 37150433
pii: S0031-9422(23)00125-5
doi: 10.1016/j.phytochem.2023.113709
pii:
doi:
Substances chimiques
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113709Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.