Embryo survival and fertility differ in lines divergently selected for birth weight homogeneity in mice.
litter size
robustness
survival
uniformity
Journal
Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie
ISSN: 1439-0388
Titre abrégé: J Anim Breed Genet
Pays: Germany
ID NLM: 100955807
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
revised:
09
03
2023
received:
15
11
2022
accepted:
23
04
2023
medline:
15
8
2023
pubmed:
8
5
2023
entrez:
8
5
2023
Statut:
ppublish
Résumé
The selection of animals for lower environment sensitivity around the optimum trait value can also provide benefits in productivity and welfare. A divergent selection experiment for birth weight environmental variability in mice was successfully conducted over 17 generations. Animals from low variability selected line (L-line) were more robust by having a higher litter size and survival at weaning in a common breeding environment, than those from high variability line (H-line). The objective of this study was to analyze the differences between those divergently selected lines for embryo and fetal survival and for fertility and prolificacy rate. To study embryo survival and ovulation rate, a total of 98 females (34 H-line and 50 L-line) were studied in four generations of the divergent experiment. To analyze fetal survival and fertility rate, 378 female mice (138 H-line and 240 L-line) in 10 generations or the divergent experiment were studied. Ultrasound scans were performed at day 14 of gestation to establish the number of total fetal and the embryo absorptions. Mortality was addressed as the difference between litter size at birth and the number of fetuses at 14 days of gestation. The number of pregnant females in the first 3 days after mating was used to measure fertility. A linear model was also fitted to analyze embryo mortality, litter size, and the number of embryos at 14 days of gestation. A categorical model was then used to study fertility, including line, generation, and its interaction as effects. Despite the fact that there were no significant differences in the ovulation rate, litter size at birth was significantly higher in the L-line than in the H-line (9.82 vs. 8.36 pups, p < 0.001). Moreover, embryo mortality was significantly lower in the L-line than in the H-line (1.39 vs. 2.87 fetuses, p < 0.001). L-line females were more fertile (53.49% vs. 23.26% for the H-line). According to these results, the line selected for low environmental variance would be preferable for robustness and animal welfare.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
549-557Subventions
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : PGC2018-096198-A-I00
Informations de copyright
© 2023 The Authors. Journal of Animal Breeding and Genetics published by John Wiley & Sons Ltd.
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