Dietary cholesterol in alcohol-associated liver disease.

alcohol alcohol-associated liver disease cholesterol cholesterol-lowering pharmacotherapies

Journal

Immunometabolism (Cobham, Surrey)
ISSN: 2633-0407
Titre abrégé: Immunometabolism (Cobham)
Pays: England
ID NLM: 9918435781306676

Informations de publication

Date de publication:
Apr 2023
Historique:
received: 20 01 2023
accepted: 13 04 2023
medline: 8 5 2023
pubmed: 8 5 2023
entrez: 8 5 2023
Statut: epublish

Résumé

There is an increasing prevalence of alcohol-associated liver disease (ALD) worldwide. In addition to excessive alcohol consumption, other nutritional factors have been shown to affect the initiation and progression of ALD. The emerging role of cholesterol in exacerbating ALD has been reported recently and the underlying mechanisms are discussed. In addition, the interplay between dietary cholesterol and alcohol on cholesterol metabolism is reviewed. Furthermore, we highlight the therapeutic potential of cholesterol-lowering drugs in managing the onset and severity of ALD. Finally, we suggest the future mechanistic investigation of the effect of cholesterol on insulin resistance and intestinal inflammation in the exacerbation of alcohol-induced cellular and systemic dysfunction.

Identifiants

pubmed: 37152117
doi: 10.1097/IN9.0000000000000026
pmc: PMC10158609
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

e00026

Informations de copyright

Copyright © 2023 The Author(s), Published by Wolters Kluwer Health, Inc.

Déclaration de conflit d'intérêts

The author declare that she has no conflicts of interest.

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Auteurs

Lin Jia (L)

Department of Biological Sciences, The University of Texas at Dallas, Richardson, TX, USA.

Classifications MeSH