Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex.
Ccr4-Not
deadenylase
deadenylation
degradation
gene expression
gene regulation
mRNA
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2023
2023
Historique:
received:
29
01
2023
accepted:
20
03
2023
medline:
8
5
2023
pubmed:
8
5
2023
entrez:
8
5
2023
Statut:
epublish
Résumé
Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation. In recent years, significant progress has been made about the role of sequence elements in the 3' untranslated region for the regulation of mRNA degradation, and a model has emerged in which recruitment of the Ccr4-Not complex is the critical step in the regulation of mRNA decay. Recruitment of the Ccr4-Not complex to a target mRNA results in deadenylation mediated by the Caf1 and Ccr4 catalytic subunits of the complex. Following deadenylation, the 5' cap structure is removed, and the mRNA subjected to 5'-3' degradation. Here, the role of the human Ccr4-Not complex in cytoplasmic deadenylation of mRNA is reviewed, with a particular focus on mechanisms of its recruitment to mRNA by sequence motifs in the 3' untranslated region, codon usage, as well as general mechanisms involving the poly(A) tail.
Identifiants
pubmed: 37152278
doi: 10.3389/fcell.2023.1153624
pii: 1153624
pmc: PMC10157403
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1153624Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/E02338X/1
Pays : United Kingdom
Informations de copyright
Copyright © 2023 Pavanello, Hall and Winkler.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Wiley Interdiscip Rev RNA. 2011 Mar-Apr;2(2):167-83
pubmed: 21957004
Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3879-84
pubmed: 22343534
J Mol Cell Biol. 2021 Feb 15;12(11):894-905
pubmed: 33104214
RNA. 2014 Sep;20(9):1465-75
pubmed: 25035297
EMBO J. 2021 Feb 1;40(3):e105977
pubmed: 33470439
RNA. 2020 Sep;26(9):1143-1159
pubmed: 32404348
Biochim Biophys Acta Gene Regul Mech. 2020 Sep;1863(9):194595
pubmed: 32565401
Genes Dev. 1994 Apr 1;8(7):855-66
pubmed: 7926773
J Mol Biol. 2001 Dec 7;314(4):683-94
pubmed: 11733989
Mol Biol Cell. 2011 Mar 15;22(6):748-58
pubmed: 21233283
Mol Microbiol. 2012 Feb;83(3):640-53
pubmed: 22243599
Nat Rev Mol Cell Biol. 2022 Feb;23(2):93-106
pubmed: 34594027
Structure. 2015 May 5;23(5):921-928
pubmed: 25914052
Nat Struct Mol Biol. 2017 Dec;24(12):1057-1063
pubmed: 29106412
Nat Struct Mol Biol. 2013 Nov;20(11):1289-97
pubmed: 24121232
Nat Struct Mol Biol. 2013 Nov;20(11):1281-8
pubmed: 24121231
Nature. 2011 Jul 27;476(7360):298-303
pubmed: 21796119
Cell Rep. 2016 Nov 15;17(8):1978-1989
pubmed: 27851962
Nat Struct Mol Biol. 2004 Feb;11(2):121-7
pubmed: 14749774
Mol Cell. 2018 Jun 21;70(6):1081-1088.e5
pubmed: 29932901
Science. 2018 Aug 17;361(6403):701-704
pubmed: 30026317
Nat Rev Mol Cell Biol. 2008 Apr;9(4):337-44
pubmed: 18334997
PLoS Genet. 2016 Jan 25;12(1):e1005820
pubmed: 26807845
Mol Cell. 2012 Oct 26;48(2):207-18
pubmed: 22959269
Nucleic Acids Res. 2011 May;39(10):4373-86
pubmed: 21278420
Nat Struct Mol Biol. 2014 Aug;21(8):679-85
pubmed: 25026078
Biosci Rep. 2019 Jun 4;39(6):
pubmed: 31097674
RNA Biol. 2021 Dec;18(12):2450-2465
pubmed: 34060423
Science. 2013 Apr 5;340(6128):82-5
pubmed: 23559250
RNA. 2005 Jul;11(7):1131-40
pubmed: 15929942
J Biol Chem. 2009 May 8;284(19):13244-55
pubmed: 19276069
Cell. 2013 May 9;153(4):869-81
pubmed: 23663784
Structure. 2004 Apr;12(4):633-44
pubmed: 15062086
Nat Commun. 2016 Aug 25;7:12626
pubmed: 27558897
Genes Dev. 2014 Apr 15;28(8):888-901
pubmed: 24736845
FEBS Lett. 2011 Jul 21;585(14):2182-6
pubmed: 21669201
RNA. 2004 Oct;10(10):1518-25
pubmed: 15337849
Life Sci Alliance. 2020 Apr 1;3(5):
pubmed: 32238456
EMBO J. 2016 May 2;35(9):974-90
pubmed: 26968986
Nat Commun. 2016 Jan 25;7:10433
pubmed: 26804377
Cell. 2015 Mar 12;160(6):1111-24
pubmed: 25768907
Mol Cell. 2014 Jun 5;54(5):751-65
pubmed: 24768538
Nucleic Acids Res. 2012 Nov;40(21):11058-72
pubmed: 22977175
Oncogene. 2014 Jan 2;33(1):55-64
pubmed: 23178487
Trends Pharmacol Sci. 2016 Oct;37(10):811-821
pubmed: 27503556
Nat Commun. 2016 Feb 25;7:10811
pubmed: 26912148
Dev Cell. 2007 Nov;13(5):691-704
pubmed: 17981137
Cell Rep. 2021 Aug 31;36(9):109633
pubmed: 34469733
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Nucleic Acids Res. 2008 Dec;36(21):6872-81
pubmed: 18974182
EMBO J. 2011 Apr 6;30(7):1311-23
pubmed: 21336257
Nucleic Acids Res. 2021 Jun 21;49(11):6489-6510
pubmed: 34038562
Cell Rep. 2023 Jan 31;42(1):111902
pubmed: 36586408
EMBO J. 2008 Apr 9;27(7):1039-48
pubmed: 18337750
Mol Cell. 2011 Oct 7;44(1):120-33
pubmed: 21981923
Genes Dev. 2019 Feb 1;33(3-4):236-252
pubmed: 30692204
Protein Sci. 2022 Mar;31(3):758-764
pubmed: 34923703
Mol Cell. 2018 Jun 21;70(6):1089-1100.e8
pubmed: 29932902
Nat Genet. 2013 Feb;45(2):186-90
pubmed: 23263491
Mol Cell Biol. 1987 Aug;7(8):2914-24
pubmed: 2823108
Mol Cell Biol. 2007 Nov;27(22):7791-801
pubmed: 17785442
Gene. 2012 Jan 15;492(1):42-53
pubmed: 22027279
Nat Struct Mol Biol. 2005 Dec;12(12):1054-63
pubmed: 16284618
Nat Commun. 2021 Dec 9;12(1):7175
pubmed: 34887419
Biochem J. 2015 Jul 1;469(1):169-76
pubmed: 25944446
EMBO J. 2019 Mar 1;38(5):
pubmed: 30609991
RNA Biol. 2013 Feb;10(2):228-44
pubmed: 23303381
Cell Res. 2014 Dec;24(12):1490-2
pubmed: 25412658
Genes Dev. 2005 Feb 1;19(3):351-61
pubmed: 15687258
Protein Sci. 2007 Feb;16(2):176-88
pubmed: 17189474
Trends Biochem Sci. 2009 Dec;34(12):640-7
pubmed: 19828319
PLoS One. 2012;7(12):e51331
pubmed: 23236473
Clin Genet. 2020 Oct;98(4):408-412
pubmed: 32720325
Biochim Biophys Acta. 2014 Nov;1839(11):1062-8
pubmed: 25120199
J Biol Chem. 2007 Jul 27;282(30):21818-28
pubmed: 17545151
Mol Cell Biol. 2012 Mar;32(6):1089-98
pubmed: 22252318
RNA Biol. 2013 Feb;10(2):267-76
pubmed: 23232451
Nucleic Acids Res. 2023 May 8;51(8):3950-3970
pubmed: 36951092
Elife. 2019 Apr 23;8:
pubmed: 31012849
J Biol Chem. 2007 Jan 5;282(1):109-14
pubmed: 17090538
Nat Struct Mol Biol. 2011 Oct 07;18(11):1218-26
pubmed: 21984184
Nat Struct Mol Biol. 2006 Jun;13(6):533-9
pubmed: 16715093
J Struct Biol. 2018 Dec;204(3):388-395
pubmed: 30367941
Genome Biol. 2022 Sep 12;23(1):193
pubmed: 36096941
EMBO J. 2010 Aug 4;29(15):2566-76
pubmed: 20628353
Development. 2006 Nov;133(22):4573-83
pubmed: 17050620
RNA. 2007 Jul;13(7):998-1016
pubmed: 17513695
J Mol Biol. 2018 Mar 2;430(5):722-736
pubmed: 29291391
Science. 2020 Mar 13;367(6483):1255-1260
pubmed: 32165587
RNA. 2018 Mar;24(3):381-395
pubmed: 29255063
Nat Struct Mol Biol. 2013 Jun;20(6):735-9
pubmed: 23644599
RNA. 2013 Mar;19(3):295-305
pubmed: 23340509
J Cell Physiol. 2010 Jan;222(1):66-72
pubmed: 19746446
Nat Commun. 2017 Feb 06;8:14307
pubmed: 28165457
RNA Biol. 2020 Mar;17(3):403-416
pubmed: 31924127
Nature. 2006 Jul 6;442(7098):45-50
pubmed: 16823445
Nat Commun. 2019 Jul 18;10(1):3173
pubmed: 31320642
Epigenetics Chromatin. 2015 Aug 15;8:28
pubmed: 26279681
J Mol Biol. 2022 Jul 30;434(14):167662
pubmed: 35640718
Nat Struct Mol Biol. 2020 Jun;27(6):581-588
pubmed: 32451488
Mol Biol Cell. 2009 Sep;20(17):3840-50
pubmed: 19605561
Mol Cell. 2014 Jun 5;54(5):737-50
pubmed: 24768540
Nat Struct Mol Biol. 2011 Oct 07;18(11):1211-7
pubmed: 21984185
EMBO Rep. 2006 Jan;7(1):72-7
pubmed: 16299471
EMBO J. 2016 Oct 4;35(19):2087-2103
pubmed: 27436874
Science. 2020 Apr 17;368(6488):
pubmed: 32299921
Nat Rev Genet. 2015 Jul;16(7):421-33
pubmed: 26077373
Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):561-70
pubmed: 23337855
Nat Struct Mol Biol. 2019 Jun;26(6):433-442
pubmed: 31110294