Hybridization alters the gut microbial and metabolic profile concurrent with modifying intestinal functions in Tunchang pigs.
gut metabolome
gut microbiome
intestinal function
mammalian hybridization
wild boar
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2023
2023
Historique:
received:
06
02
2023
accepted:
15
03
2023
medline:
8
5
2023
pubmed:
8
5
2023
entrez:
8
5
2023
Statut:
epublish
Résumé
Hybridization has been widely used among Chinese wild boars to improve their growth performance and maintain meat quality. Most studies have focused on the genetic basis for such variation. However, the differences in the gut environment between hybrid and purebred boars, which can have significant impacts on their health and productivity, have been poorly understood. In the current study, metagenomics was used to detect the gut microbial diversity and composition in hybrid Batun (BT, Berkshire × Tunchang) pigs and purebred Tunchang (TC) pigs. Additionally, untargeted metabolomic analysis was used to detect differences in gut metabolic pathways. Furthermore, multiple molecular experiments were conducted to demonstrate differences in intestinal functions. As a result of hybridization in TC pigs, a microbial change was observed, especially in Evidences were shown that hybridization changed the gut microbiome, gut metabolome, and intestinal functions of TC pigs. These findings supported our hypothesis that hybridization altered the gut microbial composition, thereby modifying the intestinal functions, even the host phenotypes. Overall, our study highlights the importance of considering the gut microbiome as a key factor in the evaluation of animal health and productivity, particularly in the context of genetic selection and breeding programs.
Identifiants
pubmed: 37152756
doi: 10.3389/fmicb.2023.1159653
pmc: PMC10157192
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1159653Informations de copyright
Copyright © 2023 He, Zhang, Li, Xie, Huang, Peng, Zhao and Wang.
Déclaration de conflit d'intérêts
HL was employed by Long Jian Animal Husbandry Company. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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