DNA methylation changes underlie the long-term association between periodontitis and atherosclerotic cardiovascular disease.
DNA methylation
Porphyromonas gingivalis
atherosclerosis
epigenetics
periodontal disease
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2023
2023
Historique:
received:
12
02
2023
accepted:
22
03
2023
medline:
8
5
2023
pubmed:
8
5
2023
entrez:
8
5
2023
Statut:
epublish
Résumé
Periodontitis, the leading cause of adult tooth loss, has been identified as an independent risk factor for cardiovascular disease (CVD). Studies suggest that periodontitis, like other CVD risk factors, shows the persistence of increased CVD risk even after mitigation. We hypothesized that periodontitis induces epigenetic changes in hematopoietic stem cells in the bone marrow (BM), and such changes persist after the clinical elimination of the disease and underlie the increased CVD risk. We used a BM transplant approach to simulate the clinical elimination of periodontitis and the persistence of the hypothesized epigenetic reprogramming. Using the low-density lipoprotein receptor knockout (
Identifiants
pubmed: 37153468
doi: 10.3389/fcvm.2023.1164499
pmc: PMC10160482
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1164499Informations de copyright
© 2023 Omar, Alexiou, Rekhi, Lehmann, Bhardwaj, Delyea, Elahi and Febbraio.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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