Towards a better understanding of human iNKT cell subpopulations for improved clinical outcomes.
CD1d
cancer
iNKT cell
immunotharapy
lipid
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
28
02
2023
accepted:
04
04
2023
medline:
9
5
2023
pubmed:
8
5
2023
entrez:
8
5
2023
Statut:
epublish
Résumé
Invariant natural killer T (iNKT) cells are a unique T lymphocyte population expressing semi-invariant T cell receptors (TCRs) that recognise lipid antigens presented by CD1d. iNKT cells exhibit potent anti-tumour activity through direct killing mechanisms and indirectly through triggering the activation of other anti-tumour immune cells. Because of their ability to induce potent anti-tumour responses, particularly when activated by the strong iNKT agonist αGalCer, they have been the subject of intense research to harness iNKT cell-targeted immunotherapies for cancer treatment. However, despite potent anti-tumour efficacy in pre-clinical models, the translation of iNKT cell immunotherapy into human cancer patients has been less successful. This review provides an overview of iNKT cell biology and why they are of interest within the context of cancer immunology. We focus on the iNKT anti-tumour response, the seminal studies that first reported iNKT cytotoxicity, their anti-tumour mechanisms, and the various described subsets within the iNKT cell repertoire. Finally, we discuss several barriers to the successful utilisation of iNKT cells in human cancer immunotherapy, what is required for a better understanding of human iNKT cells, and the future perspectives facilitating their exploitation for improved clinical outcomes.
Identifiants
pubmed: 37153585
doi: 10.3389/fimmu.2023.1176724
pmc: PMC10154573
doi:
Substances chimiques
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1176724Subventions
Organisme : Blood Cancer UK
ID : 14043
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/W007045/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S024220/1
Pays : United Kingdom
Informations de copyright
Copyright © 2023 Look, Burns, Tews, Roghanian and Mansour.
Déclaration de conflit d'intérêts
A.R. receives institutional support for grants and patents from BioInvent International. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be constructed as a potential conflict of interest.
Références
J Clin Invest. 2016 Jun 1;126(6):2341-55
pubmed: 27183388
Blood. 2002 Jul 1;100(1):11-6
pubmed: 12070001
Curr Protoc Immunol. 2017 Nov 1;119:14.11.1-14.11.20
pubmed: 29091262
Arch Pharm Res. 2019 Jul;42(7):543-548
pubmed: 30859410
J Clin Immunol. 2012 Oct;32(5):1071-81
pubmed: 22534863
J Immunol. 2017 Feb 15;198(4):1452-1459
pubmed: 28062695
Nat Immunol. 2011 Nov 27;13(1):35-43
pubmed: 22120117
Science. 2009 Sep 4;325(5945):1265-9
pubmed: 19729659
J Immunol. 2003 Jun 15;170(12):5815-9
pubmed: 12794105
Int J Mol Sci. 2022 Jul 07;23(14):
pubmed: 35886891
Hum Immunol. 2004 Nov;65(11):1377-88
pubmed: 15556688
Blood. 2012 May 24;119(21):5030-6
pubmed: 22371885
Cell. 2010 Apr 2;141(1):39-51
pubmed: 20371344
J Exp Med. 2005 May 2;201(9):1503-17
pubmed: 15867097
Int J Cancer. 2001 Feb 15;91(4):523-8
pubmed: 11251976
Clin Immunol. 2022 May;238:108992
pubmed: 35367396
Clin Cancer Res. 2000 Aug;6(8):3380-7
pubmed: 10955826
Clin Cancer Res. 2005 Mar 1;11(5):1910-7
pubmed: 15756017
Clin Immunol. 2011 Aug;140(2):119-29
pubmed: 21095162
Mol Immunol. 2021 Feb;130:1-6
pubmed: 33340930
Front Immunol. 2020 Nov 27;11:567406
pubmed: 33329531
J Exp Med. 2010 Jun 7;207(6):1235-46
pubmed: 20479114
Nature. 2007 Jul 5;448(7149):44-9
pubmed: 17581592
Nat Rev Immunol. 2012 Dec;12(12):845-57
pubmed: 23154222
Cancer Res. 1999 Oct 15;59(20):5102-5
pubmed: 10537282
Blood. 2013 Jan 17;121(3):423-30
pubmed: 23100308
Int J Cancer. 2005 Aug 10;116(1):87-93
pubmed: 15756674
J Exp Med. 2004 Nov 15;200(10):1325-35
pubmed: 15545356
Nat Immunol. 2013 Nov;14(11):1146-54
pubmed: 24097110
PLoS Biol. 2010 Jun 22;8(6):e1000402
pubmed: 20585371
Nat Rev Immunol. 2013 Feb;13(2):101-17
pubmed: 23334244
Scand J Immunol. 2020 Dec;92(6):e12983
pubmed: 33037653
J Exp Med. 2003 Oct 6;198(7):1069-76
pubmed: 14530376
Mol Immunol. 2019 Jan;105:116-130
pubmed: 30502719
Nat Commun. 2020 Jul 30;11(1):3801
pubmed: 32732879
Clin Cancer Res. 2011 Aug 1;17(15):5140-51
pubmed: 21653690
Eur J Immunol. 2008 Apr;38(4):1012-23
pubmed: 18350544
J Immunol. 2012 Jan 15;188(2):624-31
pubmed: 22156591
J Exp Med. 2005 Nov 7;202(9):1279-88
pubmed: 16275765
Sci Immunol. 2022 Oct 28;7(76):eabj8760
pubmed: 36269840
J Exp Med. 2002 Mar 4;195(5):625-36
pubmed: 11877485
Science. 2013 Jan 18;339(6117):286-91
pubmed: 23329041
Nature. 2022 Jan;601(7891):125-131
pubmed: 34880496
Heredity (Edinb). 2021 Jan;126(1):107-116
pubmed: 32868871
Front Immunol. 2022 Oct 03;13:1011209
pubmed: 36263021
J Exp Med. 2002 Mar 4;195(5):637-41
pubmed: 11877486
Immunol Rev. 2007 Dec;220:183-98
pubmed: 17979847
Immunity. 2009 Jul 17;31(1):60-71
pubmed: 19592274
Clin Cancer Res. 2002 Dec;8(12):3702-9
pubmed: 12473579
Immunol Rev. 2010 May;235(1):73-92
pubmed: 20536556
Semin Immunol. 1997 Apr;9(2):117-25
pubmed: 9194222
Nat Rev Immunol. 2009 Jan;9(1):28-38
pubmed: 19079136
Nat Rev Immunol. 2009 Mar;9(3):162-74
pubmed: 19197294
J Immunol. 2001 Jul 1;167(1):350-6
pubmed: 11418670
Blood. 2014 Oct 30;124(18):2824-33
pubmed: 25049283
Cent Eur J Immunol. 2017;42(2):181-195
pubmed: 28860937
Science. 1997 Nov 28;278(5343):1623-6
pubmed: 9374462
Elife. 2019 Dec 16;8:
pubmed: 31841113
J Exp Med. 2002 Apr 15;195(8):991-1001
pubmed: 11956290
J Biomed Sci. 2017 Mar 23;24(1):22
pubmed: 28335781
Nat Immunol. 2015 Jan;16(1):85-95
pubmed: 25436972
Oncogene. 2008 Oct 6;27(45):5904-12
pubmed: 18836471
Blood. 2009 Mar 12;113(11):2498-507
pubmed: 19056691
Nat Immunol. 2012 Jul 19;13(8):705-6
pubmed: 22814339
Immunology. 2000 Feb;99(2):229-34
pubmed: 10692041
Annu Rev Immunol. 2014;32:323-66
pubmed: 24499274
Nat Rev Immunol. 2015 Jun;15(6):388-400
pubmed: 25998963
J Immunother Cancer. 2020 Mar;8(1):
pubmed: 32188702
Front Immunol. 2018 Mar 02;9:384
pubmed: 29559971
J Immunol. 2015 Aug 15;195(4):1459-69
pubmed: 26157173
Int Rev Immunol. 2007 Jan-Apr;26(1-2):31-48
pubmed: 17454263
Proc Natl Acad Sci U S A. 1998 May 12;95(10):5690-3
pubmed: 9576945
Crit Rev Oncol Hematol. 2008 Apr;66(1):1-9
pubmed: 17913510
Stem Cell Reports. 2016 Feb 9;6(2):213-27
pubmed: 26862702
J Immunol. 2015 Nov 15;195(10):4604-14
pubmed: 26423148
Nat Immunol. 2011 Jun 19;12(8):770-7
pubmed: 21685908
Front Med (Lausanne). 2022 May 09;9:897750
pubmed: 35615083
J Immunol. 1999 Sep 1;163(5):2387-91
pubmed: 10452972
Scand J Immunol. 2011 Oct;74(4):406-11
pubmed: 21671972
Leukemia. 2017 Apr;31(4):903-912
pubmed: 27740636
PLoS One. 2010 Nov 03;5(11):e15412
pubmed: 21082024
J Exp Med. 2008 Sep 29;205(10):2309-18
pubmed: 18809713
Eur J Immunol. 2011 Jul;41(7):1913-23
pubmed: 21590763
Br J Pharmacol. 2012 Dec;167(7):1533-49
pubmed: 22817659
PLoS One. 2011;6(6):e20702
pubmed: 21695190
Cell Rep. 2021 May 25;35(8):109174
pubmed: 34038736
PLoS One. 2016 Apr 11;11(4):e0153347
pubmed: 27064277
Nat Biotechnol. 2014 Jul;32(7):684-92
pubmed: 24952902
Clin Cancer Res. 2017 Jul 15;23(14):3510-3519
pubmed: 28193627
J Gastroenterol Hepatol. 2007 Aug;22(8):1322-7
pubmed: 17688669
J Immunol. 2009 Apr 1;182(7):4439-47
pubmed: 19299745
J Clin Invest. 2009 Jun;119(6):1524-36
pubmed: 19411762
Nat Rev Immunol. 2018 Sep;18(9):559-574
pubmed: 29967365
J Immunol. 2001 Oct 1;167(7):4046-50
pubmed: 11564825
J Clin Invest. 2008 Dec;118(12):4036-48
pubmed: 19033672
Cancer Immunol Res. 2019 Nov;7(11):1876-1890
pubmed: 31451483
Cancer Res. 2006 Dec 1;66(23):11441-6
pubmed: 17145891
Clin Transl Immunology. 2016 Apr 08;5(4):e69
pubmed: 27195112
Nat Rev Clin Oncol. 2023 Mar;20(3):192-206
pubmed: 36635480
Nat Rev Immunol. 2010 Sep;10(9):621-31
pubmed: 20689559
Blood. 2002 Feb 15;99(4):1259-66
pubmed: 11830474
Nat Immunol. 2003 Dec;4(12):1230-7
pubmed: 14578883
Immunohorizons. 2019 Jun 11;3(6):203-207
pubmed: 31356166
J Immunol. 2018 Oct 1;201(7):2141-2153
pubmed: 30111631
Cancer Cell. 2018 Oct 8;34(4):596-610.e11
pubmed: 30300581
J Immunol. 2007 Dec 15;179(12):8172-9
pubmed: 18056360
Curr Opin Immunol. 2008 Jun;20(3):358-68
pubmed: 18501573
Leuk Lymphoma. 2006 Oct;47(10):2218-23
pubmed: 17071498
J Immunol. 2015 Dec 15;195(12):5582-91
pubmed: 26553073
Cancer Res. 1998 Mar 15;58(6):1202-7
pubmed: 9515806
Cancer Immunol Immunother. 2021 May;70(5):1239-1254
pubmed: 33128583
J Autoimmun. 2016 Apr;68:39-51
pubmed: 26748722
Cancer Sci. 2010 Nov;101(11):2333-40
pubmed: 20804502
Nat Immunol. 2011 Nov 27;13(1):44-50
pubmed: 22120118
F1000Res. 2020 Feb 20;9:
pubmed: 32148771
J Immunol. 2017 Feb 1;198(3):1056-1065
pubmed: 28003379
Cancer Immunol Immunother. 2002 Jan;50(11):604-14
pubmed: 11807624
Cancer Immunol Immunother. 2014 Dec;63(12):1285-96
pubmed: 25183171
Cytokine. 2010 Sep;51(3):227-31
pubmed: 20554220
Immunol Lett. 2020 Jan;217:126-132
pubmed: 31726187
J Immunol. 2003 Nov 1;171(9):4539-51
pubmed: 14568927
J Med Chem. 1995 Jun 9;38(12):2176-87
pubmed: 7783149
J Immunol. 2003 Oct 15;171(8):4020-7
pubmed: 14530322
J Exp Med. 1994 Sep 1;180(3):1097-106
pubmed: 7520467
Transl Oncol. 2022 Jan 18;17:101342
pubmed: 35063813
Int J Mol Sci. 2020 May 30;21(11):
pubmed: 32486268
Vaccines (Basel). 2022 Dec 27;11(1):
pubmed: 36679904
Nat Immunol. 2019 Dec;20(12):1692-1699
pubmed: 31745340
Semin Cancer Biol. 2006 Feb;16(1):53-65
pubmed: 16168663
Cancers (Basel). 2021 Oct 15;13(20):
pubmed: 34680322
J Immunol. 2008 Jul 1;181(1):81-91
pubmed: 18566372
Immunology. 2007 Sep;122(1):1-14
pubmed: 17662044
Science. 1997 Nov 28;278(5343):1626-9
pubmed: 9374463
Front Immunol. 2020 Mar 12;11:339
pubmed: 32226426
BMC Biol. 2014 May 09;12:32
pubmed: 24886643
Front Immunol. 2018 Feb 27;9:367
pubmed: 29535734
Front Immunol. 2017 Sep 22;8:1178
pubmed: 29018445
Immunity. 2009 Jul 17;31(1):47-59
pubmed: 19592275
Clin Immunol. 2011 Aug;140(2):167-76
pubmed: 21349771
J Exp Med. 2002 Jul 1;196(1):119-27
pubmed: 12093876
Int Immunol. 2004 Feb;16(2):241-7
pubmed: 14734609