Deleterious impact of COVID-19 pandemic: Male fertility was not out of the bag.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2023
2023
Historique:
received:
16
02
2023
accepted:
31
03
2023
medline:
10
5
2023
pubmed:
8
5
2023
entrez:
8
5
2023
Statut:
epublish
Résumé
The emergence and the spread of coronavirus disease (COVID-19) induced by the SARS-CoV-2 virus has multiple consequences in all countries around the world. Male germ cells of infertile patients which are shown to be vulnerable to many environmental conditions, could be particularly vulnerable to such an exceptional pandemic situation. We aimed through the current study to investigate the potential variations in sperm quality of infertile patients during the COVID-19 pandemic in Tunisia. This was a cohort study including 90 infertile patients addressed to Laboratory of Cytogenetics and Reproductive Biology of Monastir Department of Maternity and Neonatology in Monastir, during the two first COVID-19 waves in Tunisia and who already have a spermogram before the pandemic period. We have pointed out a significant decrease in both total and progressive sperm motility during COVID-19 pandemic (p<0.0001 and p = 0.001 respectively). The percentage of morphologically abnormal spermatozoa increased from 90.99±7.38 to 93.67±4.55% during the pandemic (p< 0.001). The remaining sperm parameters were similar between the two compared timepoints. Interestingly, the univariate analysis didn't show any other associated factor to the observed impairment in sperm mobility and morphology. These data highlight the severe impact of the pandemic of the male reproductive health of hypofertile patients. Delaying infertility investigations and management after pandemic waves is recommended to hope a better gamete quality and hence to improve conception potential.
Sections du résumé
BACKGROUND
The emergence and the spread of coronavirus disease (COVID-19) induced by the SARS-CoV-2 virus has multiple consequences in all countries around the world. Male germ cells of infertile patients which are shown to be vulnerable to many environmental conditions, could be particularly vulnerable to such an exceptional pandemic situation. We aimed through the current study to investigate the potential variations in sperm quality of infertile patients during the COVID-19 pandemic in Tunisia.
METHODS
This was a cohort study including 90 infertile patients addressed to Laboratory of Cytogenetics and Reproductive Biology of Monastir Department of Maternity and Neonatology in Monastir, during the two first COVID-19 waves in Tunisia and who already have a spermogram before the pandemic period.
RESULTS
We have pointed out a significant decrease in both total and progressive sperm motility during COVID-19 pandemic (p<0.0001 and p = 0.001 respectively). The percentage of morphologically abnormal spermatozoa increased from 90.99±7.38 to 93.67±4.55% during the pandemic (p< 0.001). The remaining sperm parameters were similar between the two compared timepoints. Interestingly, the univariate analysis didn't show any other associated factor to the observed impairment in sperm mobility and morphology.
CONCLUSION
These data highlight the severe impact of the pandemic of the male reproductive health of hypofertile patients. Delaying infertility investigations and management after pandemic waves is recommended to hope a better gamete quality and hence to improve conception potential.
Identifiants
pubmed: 37155673
doi: 10.1371/journal.pone.0284489
pii: PONE-D-23-04646
pmc: PMC10166489
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0284489Informations de copyright
Copyright: © 2023 Garrouch et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Andrologia. 2022 Mar;54(2):e14295
pubmed: 34716614
Clin Rheumatol. 2021 Jul;40(7):2611-2619
pubmed: 33733315
Andrology. 2021 Jan;9(1):48-52
pubmed: 32649023
J Med Virol. 2021 Jan;93(1):456-462
pubmed: 32621617
J Reprod Immunol. 2003 Feb;58(1):1-26
pubmed: 12609522
J Endocrinol Invest. 2021 Feb;44(2):223-231
pubmed: 32661947
PLoS One. 2021 Dec 14;16(12):e0260187
pubmed: 34905541
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Andrology. 2021 Jan;9(1):42-47
pubmed: 32598557
Fertil Steril. 2020 Aug;114(2):257-258
pubmed: 32650949
Biochemistry (Mosc). 2021 Apr;86(4):389-396
pubmed: 33941061
Physiol Rep. 2021 Feb;9(3):e14726
pubmed: 33523608
Turk J Med Sci. 2017 Jun 12;47(3):902-907
pubmed: 28618741
J Endocrinol Invest. 2020 Dec;43(12):1819-1822
pubmed: 32329026
Hum Reprod. 2007 Jan;22(1):305-8
pubmed: 16973721
Fertil Steril. 2021 Apr;115(4):811-812
pubmed: 33832740
Rev Endocr Metab Disord. 2021 Dec;22(4):803-815
pubmed: 33241508
Reproduction. 2021 Mar;161(3):319-331
pubmed: 33522983
Sleep Med. 2020 Jun;70:124
pubmed: 32408252
Cells. 2020 Apr 09;9(4):
pubmed: 32283711
Int J Impot Res. 2020 Sep;32(5):560-562
pubmed: 32796934
Hum Reprod. 2005 Sep;20(9):2595-600
pubmed: 15890736
Indian J Ophthalmol. 2021 Mar;69(3):488-509
pubmed: 33595463
Fertil Steril. 2020 Jun;113(6):1135-1139
pubmed: 32482249
Fertil Steril. 2020 Aug;114(2):233-238
pubmed: 32650948
Andrologia. 2021 Feb;53(1):e13617
pubmed: 32399992
Environ Sci Pollut Res Int. 2021 Jan;28(4):4095-4103
pubmed: 33196997
Eur J Obstet Gynecol Reprod Biol. 2011 Oct;158(2):235-41
pubmed: 21641108
Andrologia. 2020 Mar;52(2):e13460
pubmed: 31691340
Urol Int. 2020;104(9-10):678-683
pubmed: 32781456
J Assist Reprod Genet. 2021 Apr;38(4):785-789
pubmed: 33660204
Cell J. 2021 Sep;23(4):382-388
pubmed: 34455712
Asian J Androl. 2016 Nov-Dec;18(6):844-850
pubmed: 27624988
Reprod Biomed Online. 2020 Jul;41(1):89-95
pubmed: 32466994
Syst Biol Reprod Med. 2021 Feb;67(1):3-23
pubmed: 33719829
Int J Environ Res Public Health. 2022 Mar 10;19(6):
pubmed: 35328944
Andrology. 2021 Jul;9(4):1060-1065
pubmed: 33851521
World J Urol. 2021 Mar;39(3):975-976
pubmed: 32318855
Aust N Z J Psychiatry. 2021 Aug;55(8):750-762
pubmed: 32998512
J Endocrinol Invest. 2022 Aug;45(8):1483-1495
pubmed: 35181849
Contracept Fertil Sex. 1994 May;22(5):314-8
pubmed: 8032387
Andrologia. 2020 Oct;52(9):e13791
pubmed: 32790205
Hum Reprod. 2021 May 17;36(6):1520-1529
pubmed: 33522572
World J Mens Health. 2021 Jul;39(3):489-495
pubmed: 33663031
JAMA. 2021 Jul 06;326(1):65-76
pubmed: 34228062
World J Mens Health. 2021 Oct;39(4):577-580
pubmed: 34169684
Emerg Microbes Infect. 2021 Dec;10(1):507-535
pubmed: 33666147
BMC Public Health. 2019 Jan 8;19(1):36
pubmed: 30621647
Andrology. 2022 Jan;10(1):8-10
pubmed: 34411453
Biol Reprod. 2020 Jun 23;103(1):4-6
pubmed: 32297920
Andrologia. 2021 Feb;53(1):e13914
pubmed: 33236375
JAMA Netw Open. 2020 May 1;3(5):e208292
pubmed: 32379329
J Med Internet Res. 2020 Aug 6;22(8):e20961
pubmed: 32716895
Microsc Res Tech. 2009 Aug;72(8):620-8
pubmed: 19263422