Croquemort elicits activation of the immune deficiency pathway in ticks.


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
16 05 2023
Historique:
medline: 10 5 2023
pubmed: 8 5 2023
entrez: 8 5 2023
Statut: ppublish

Résumé

The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit the IMD pathway in non-insect arthropods remain elusive. Here, we show that an

Identifiants

pubmed: 37155900
doi: 10.1073/pnas.2208673120
pmc: PMC10193931
doi:

Substances chimiques

NF-kappa B 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2208673120

Subventions

Organisme : NIAID NIH HHS
ID : F31 AI152215
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116620
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI148578
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM129327
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI138949
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI139772
Pays : United States
Organisme : NIAID NIH HHS
ID : F31 AI167471
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116523
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI134696
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI049424
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI052397
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI080615
Pays : United States

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Auteurs

Anya J O'Neal (AJ)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.

Nisha Singh (N)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.

Agustin Rolandelli (A)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.

Hanna J Laukaitis (HJ)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.

Xiaowei Wang (X)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.

Dana K Shaw (DK)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164.

Brianna D Young (BD)

Department of Biochemistry and Molecular Biology, Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201.

Sukanya Narasimhan (S)

Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06510.

Shraboni Dutta (S)

Department of Veterinary Medicine, University of Maryland, College Park, MD 20742.

Greg A Snyder (GA)

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201.

Sourabh Samaddar (S)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.

Liron Marnin (L)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.

L Rainer Butler (LR)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.

M Tays Mendes (MT)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.

Francy E Cabrera Paz (FE)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.

Luisa M Valencia (LM)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.

Eric J Sundberg (EJ)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201.
Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.

Erol Fikrig (E)

Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06510.

Utpal Pal (U)

Department of Veterinary Medicine, University of Maryland, College Park, MD 20742.

David J Weber (DJ)

Department of Biochemistry and Molecular Biology, Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201.

Joao H F Pedra (JHF)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.

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