The peritumor microenvironment: physics and immunity.
immunotherapy
peritumor
physical immunity
physical oncology
tumor microenvironment
Journal
Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
20
02
2023
revised:
05
04
2023
accepted:
11
04
2023
pmc-release:
01
08
2024
medline:
21
7
2023
pubmed:
9
5
2023
entrez:
8
5
2023
Statut:
ppublish
Résumé
Cancer initiation and progression drastically alter the microenvironment at the interface between healthy and malignant tissue. This site, termed the peritumor, bears unique physical and immune attributes that together further promote tumor progression through interconnected mechanical signaling and immune activity. In this review, we describe the distinct physical features of the peritumoral microenvironment and link their relationship to immune responses. The peritumor is a region rich in biomarkers and therapeutic targets and thus is a key focus for future cancer research as well as clinical outlooks, particularly to understand and overcome novel mechanisms of immunotherapy resistance.
Identifiants
pubmed: 37156677
pii: S2405-8033(23)00060-2
doi: 10.1016/j.trecan.2023.04.004
pmc: PMC10523902
mid: NIHMS1892247
pii:
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
609-623Subventions
Organisme : NHLBI NIH HHS
ID : DP2 HL168562
Pays : United States
Organisme : NCI NIH HHS
ID : K22 CA258410
Pays : United States
Organisme : NIBIB NIH HHS
ID : R21 EB031332
Pays : United States
Organisme : NIBIB NIH HHS
ID : T32 EB006359
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests None are declared by the authors.
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