Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis.

Animals Male Mice beta Catenin / metabolism Carcinogenesis / genetics Carcinoma, Hepatocellular / metabolism Fatty Acid Desaturases Hepatic Stellate Cells / metabolism Liver Neoplasms / metabolism Receptors, Leukotriene B4 / genetics Tumor Microenvironment

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
08 05 2023
Historique:
received: 11 01 2022
accepted: 02 05 2023
medline: 10 5 2023
pubmed: 9 5 2023
entrez: 8 5 2023
Statut: epublish

Résumé

Hepatocellular carcinoma (HCC) is the 3

Identifiants

DOI: 10.1038/s41467-023-38406-8 PMID: 37156770 PMC: PMC10167314
pubmed: 37156770
doi: 10.1038/s41467-023-38406-8
pii: 10.1038/s41467-023-38406-8
pmc: PMC10167314
doi:

Substances chimiques

beta Catenin 0
Fatty Acid Desaturases EC 1.14.19.-
Receptors, Leukotriene B4 0
Scd2 protein, mouse EC 1.14.19.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2651

Subventions

Organisme : NIAAA NIH HHS
ID : U01 AA027681
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA273538
Pays : United States
Organisme : NIAAA NIH HHS
ID : P50 AA011999
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA196521
Pays : United States
Organisme : NIAAA NIH HHS
ID : R24 AA012885
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM118247
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103549
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA256480
Pays : United States
Organisme : NCI NIH HHS
ID : F32 CA247414
Pays : United States
Organisme : BLRD VA
ID : I01 BX001991
Pays : United States

Informations de copyright

© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.

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Auteurs

Sonal Sinha (S)

Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.

Satoka Aizawa (S)

Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.

Yasuhiro Nakano (Y)

Laboratory of Cell Growth and Differentiation, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, 113-0022, Japan.
ORCID: 0000-0002-8094-3185

Alexander Rialdi (A)

Icahn School of Medicine at Mount Sinai Hess Center for Science and Medicine, New York, NY, 10029, USA.

Hye Yeon Choi (HY)

Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.

Rajan Shrestha (R)

Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.

Stephanie Q Pan (SQ)

Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.

Yibu Chen (Y)

USC Libraries Bioinformatics Services of the University of Southern California, Los Angeles, CA, 90089, USA.

Meng Li (M)

USC Libraries Bioinformatics Services of the University of Southern California, Los Angeles, CA, 90089, USA.

Audrey Kapelanski-Lamoureux (A)

Research Institute of the McGill University Health Centre, Montreal, QC, H3A 0G4, Canada.
ORCID: 0000-0002-4650-6141

Gregory Yochum (G)

Department of Surgery, Pennsylvania State University, Hershey, PA, 17033, USA.

Linda Sher (L)

Department of Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.

Satdarshan Paul Monga (SP)

Department of Pathology, University of Pittsburg School of Medicine, Pittsburg, PA, 15213, USA.
ORCID: 0000-0002-8437-3378

Anthoula Lazaris (A)

Research Institute of the McGill University Health Centre, Montreal, QC, H3A 0G4, Canada.
ORCID: 0000-0002-2173-7891

Keigo Machida (K)

Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Department of Molecular Microbiology and Immunology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
ORCID: 0000-0002-9721-8553

Michael Karin (M)

Department of Pharmacology, University of California San Diego, La Jolla, CA, 92093, USA.

Ernesto Guccione (E)

Icahn School of Medicine at Mount Sinai Hess Center for Science and Medicine, New York, NY, 10029, USA.

Hidekazu Tsukamoto (H)

Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA. htsukamo@med.usc.edu.
Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA. htsukamo@med.usc.edu.
Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA. htsukamo@med.usc.edu.
ORCID: 0000-0002-6833-2998

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Hepatic stellate cell stearoyl co-A desaturase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Hepatic stellate cell stearoyl co-A desaturase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › bêta-Caténine › Hepatic stellate cell stearoyl co-A desaturase...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Hepatic stellate cell stearoyl co-A desaturase...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Carcinome hépatocellulaire › Hepatic stellate cell stearoyl co-A desaturase...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Fatty acid desaturases › Hepatic stellate cell stearoyl co-A desaturase...
questionsmedicales.fr › Cellules › Cellules étoilées du foie › Hepatic stellate cell stearoyl co-A desaturase...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Hepatic stellate cell stearoyl co-A desaturase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux éicosanoïdes › Récepteurs aux leucotriènes › Récepteurs aux leucotriènes B4 › Hepatic stellate cell stearoyl co-A desaturase...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Hepatic stellate cell stearoyl co-A desaturase...