Direct observation of the evolution of cell-type-specific microRNA expression signatures supports the hematopoietic origin model of endothelial cells.
Ciona intestinalis
Mir-126
endothelial cells
evolution of cell-types
microRNAs
Journal
Evolution & development
ISSN: 1525-142X
Titre abrégé: Evol Dev
Pays: United States
ID NLM: 100883432
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
revised:
22
03
2023
received:
04
12
2022
accepted:
26
04
2023
pmc-release:
08
05
2024
medline:
16
5
2023
pubmed:
9
5
2023
entrez:
9
5
2023
Statut:
ppublish
Résumé
The evolution of specialized cell-types is a long-standing interest of biologists, but given the deep time-scales very difficult to reconstruct or observe. microRNAs have been linked to the evolution of cellular complexity and may inform on specialization. The endothelium is a vertebrate-specific specialization of the circulatory system that enabled a critical new level of vasoregulation. The evolutionary origin of these endothelial cells is unclear. We hypothesized that Mir-126, an endothelial cell-specific microRNA may be informative. We here reconstruct the evolutionary history of Mir-126. Mir-126 likely appeared in the last common ancestor of vertebrates and tunicates, which was a species without an endothelium, within an intron of the evolutionary much older EGF Like Domain Multiple (Egfl) locus. Mir-126 has a complex evolutionary history due to duplications and losses of both the host gene and the microRNA. Taking advantage of the strong evolutionary conservation of the microRNA among Olfactores, and using RNA in situ hybridization, we localized Mir-126 in the tunicate Ciona robusta. We found exclusive expression of the mature Mir-126 in granular amebocytes, supporting a long-proposed scenario that endothelial cells arose from hemoblasts, a type of proto-endothelial amoebocyte found throughout invertebrates. This observed change of expression of Mir-126 from proto-endothelial amoebocytes in the tunicate to endothelial cells in vertebrates is the first direct observation of the evolution of a cell-type in relation to microRNA expression indicating that microRNAs can be a prerequisite of cell-type evolution.
Identifiants
pubmed: 37157156
doi: 10.1111/ede.12438
pmc: PMC10302300
mid: NIHMS1902901
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
226-239Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM130564
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137811
Pays : United States
Informations de copyright
© 2023 The Authors. Evolution & Development published by Wiley Periodicals LLC.
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