The role of efferocytosis-fueled macrophage metabolism in the resolution of inflammation.
cell metabolism
efferocytosis
inflammation resolution
macrophages
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
02
03
2023
accepted:
20
04
2023
pmc-release:
01
10
2024
medline:
30
10
2023
pubmed:
9
5
2023
entrez:
9
5
2023
Statut:
ppublish
Résumé
The phagocytosis of dying cells by macrophages, termed efferocytosis, is a tightly regulated process that involves the sensing, binding, engulfment, and digestion of apoptotic cells. Efferocytosis not only prevents tissue necrosis and inflammation caused by secondary necrosis of dying cells, but it also promotes pro-resolving signaling in macrophages, which is essential for tissue resolution and repair following injury or inflammation. An important factor that contributes to this pro-resolving reprogramming is the cargo that is released from apoptotic cells after their engulfment and phagolysosomal digestion by macrophages. The apoptotic cell cargo contains amino acids, nucleotides, fatty acids, and cholesterol that function as metabolites and signaling molecules to bring about this re-programming. Here, we review efferocytosis-induced changes in macrophage metabolism that mediate the pro-resolving functions of macrophages. We also discuss various strategies, challenges, and future perspectives related to drugging efferocytosis-fueled macrophage metabolism as strategy to dampen inflammation and promote resolution in chronic inflammatory diseases.
Identifiants
pubmed: 37158427
doi: 10.1111/imr.13214
pmc: PMC10615666
mid: NIHMS1896610
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
65-80Subventions
Organisme : American Heart Association-American Stroke Association
ID : 900337
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL087123
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL159012
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL145228
Pays : United States
Informations de copyright
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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