The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis.

Humans Child Lymphocytes Immunity, Innate / genetics Colitis / genetics Inflammatory Bowel Diseases T-Lymphocytes
IBD ILC gut immunity pediatric inflammatory bowel disease single-cell RNA sequencing tissue-resident T cells

Journal

Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894

Informations de publication

Date de publication:
16 05 2023
Historique:
received: 22 07 2022
revised: 15 12 2022
accepted: 14 04 2023
medline: 19 5 2023
pubmed: 10 5 2023
entrez: 9 5 2023
Statut: ppublish

Résumé

Innate lymphoid cells (ILCs) are considered innate counterparts of adaptive T cells; however, their common and unique transcriptional signatures in pediatric inflammatory bowel disease (pIBD) are largely unknown. Here, we report a dysregulated colonic ILC composition in pIBD colitis that correlates with inflammatory activity, including accumulation of naive-like CD45RA

Identifiants

DOI: 10.1016/j.xcrm.2023.101038 PMID: 37160121 PMC: PMC10213874
pubmed: 37160121
pii: S2666-3791(23)00152-0
doi: 10.1016/j.xcrm.2023.101038
pmc: PMC10213874
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101038

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Références

Int Immunol. 1993 Nov;5(11):1461-71
pubmed: 7903159
Gastroenterology. 2019 Feb;156(3):812-815.e22
pubmed: 30391472
Nat Methods. 2020 Feb;17(2):137-145
pubmed: 31792435
Cell Rep. 2014 Jul 10;8(1):150-62
pubmed: 24953655
Nat Commun. 2020 Apr 14;11(1):1794
pubmed: 32286285
BMC Bioinformatics. 2008 Dec 29;9:559
pubmed: 19114008
Cell Res. 2021 May;31(5):554-568
pubmed: 33420427
Nat Immunol. 2006 Dec;7(12):1334-42
pubmed: 17057721
BMC Genomics. 2018 Jun 19;19(1):477
pubmed: 29914354
Bioinformatics. 2012 Mar 15;28(6):882-3
pubmed: 22257669
Gastroenterology. 2008 Oct;135(4):1114-22
pubmed: 18725221
Nat Med. 2020 Sep;26(9):1480-1490
pubmed: 32747828
Nat Immunol. 2012 Jul 01;13(8):778-86
pubmed: 22751141
Nat Immunol. 2013 Mar;14(3):221-9
pubmed: 23334791
Eur J Immunol. 2019 Sep;49(9):1344-1355
pubmed: 31151137
Nat Immunol. 2011 Sep 11;12(11):1055-62
pubmed: 21909091
J Crohns Colitis. 2019 Sep 27;13(10):1334-1342
pubmed: 31002741
Cell. 2017 Mar 9;168(6):1086-1100.e10
pubmed: 28283063
Scand J Gastroenterol. 2019 Sep;54(9):1089-1101
pubmed: 31498717
Sci Immunol. 2022 Apr 15;7(70):eabj8301
pubmed: 35427178
Nat Commun. 2014 Apr 03;5:3551
pubmed: 24699451
Nat Immunol. 2016 Jun 21;17(7):765-74
pubmed: 27328006
Immunity. 2018 Jun 19;48(6):1104-1117
pubmed: 29924976
Clin Exp Immunol. 1991 Jun;84(3):440-4
pubmed: 1828397
Sci Immunol. 2021 Aug 13;6(62):
pubmed: 34389612
J Crohns Colitis. 2018 Mar 28;12(4):465-475
pubmed: 29211912
Nat Methods. 2019 Dec;16(12):1289-1296
pubmed: 31740819
Immunity. 2011 Jan 28;34(1):122-34
pubmed: 21194981
Eur J Immunol. 2014 Mar;44(3):654-61
pubmed: 24307243
Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12835-40
pubmed: 25136120
Curr Opin Pharmacol. 2020 Dec;55:141-150
pubmed: 33254032
World J Gastroenterol. 2014 Jan 7;20(1):91-9
pubmed: 24415861
Trends Immunol. 2008 Apr;29(4):186-94
pubmed: 18329338
Nat Immunol. 2011 Nov 20;13(2):144-51
pubmed: 22101730
Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):
pubmed: 34001664
Cell. 2019 Nov 14;179(5):1160-1176.e24
pubmed: 31730855
Nat Biotechnol. 2018 Jun;36(5):411-420
pubmed: 29608179
Immunity. 2015 Oct 20;43(4):739-50
pubmed: 26431947
Gastroenterology. 2020 Aug;159(2):591-608.e10
pubmed: 32428507
Nat Commun. 2021 Mar 26;12(1):1921
pubmed: 33771991
JGH Open. 2018 Nov 11;3(2):100-104
pubmed: 31061883
Nat Commun. 2021 Oct 6;12(1):5841
pubmed: 34615883
Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3394-402
pubmed: 27226296
J Exp Med. 2019 Jun 3;216(6):1280-1290
pubmed: 30979790
Immunity. 2019 Feb 19;50(2):505-519.e4
pubmed: 30770247
Cell. 2020 Sep 3;182(5):1252-1270.e34
pubmed: 32818467
J Exp Med. 2011 Jun 6;208(6):1127-33
pubmed: 21576383
Gastroenterology. 1998 Feb;114(2):262-7
pubmed: 9453485
Science. 2022 Apr 8;376(6589):eabf1970
pubmed: 35389781
Front Immunol. 2012 Apr 09;3:72
pubmed: 22566953
Gut. 2000 Sep;47(3):404-9
pubmed: 10940279
J Crohns Colitis. 2019 Jan 01;13(1):67-78
pubmed: 30496425
Cell. 2019 Sep 5;178(6):1493-1508.e20
pubmed: 31474370
Nature. 2021 Apr;592(7852):128-132
pubmed: 33536623
Immunity. 2013 Apr 18;38(4):769-81
pubmed: 23453631
Immunity. 2017 Jan 17;46(1):148-161
pubmed: 27986455
Cell Mol Immunol. 2022 Jul;19(7):777-790
pubmed: 35468944
Gastroenterology. 2007 Jun;132(7):2346-58
pubmed: 17570210
Nat Commun. 2020 Apr 27;11(1):2049
pubmed: 32341343
JAMA Pediatr. 2015 Nov;169(11):1053-60
pubmed: 26414706
Science. 2015 May 29;348(6238):1031-5
pubmed: 25908663
Nat Commun. 2020 Jan 20;11(1):381
pubmed: 31959757
Immunity. 2021 Jan 12;54(1):99-115.e12
pubmed: 33271118
PLoS One. 2019 Mar 7;14(3):e0203247
pubmed: 30845234
Clin Exp Immunol. 2014 May;176(2):266-74
pubmed: 24450998
Blood. 2010 Nov 4;116(18):3465-74
pubmed: 20660289

Auteurs

Efthymia Kokkinou (E)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Tea Soini (T)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Ram Vinay Pandey (RV)

Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Aline van Acker (A)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Jakob Theorell (J)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Psychiatry Southwest, Health Care Services Stockholm County, Huddinge, Sweden.

Paulo Czarnewski (P)

Science for Life Laboratory, Department of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, Stockholm University, Solna, Sweden.

Egle Kvedaraite (E)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.

Niels Vandamme (N)

Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.

Magda Lourda (M)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Chiara Sorini (C)

Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institutet and University Hospital, Stockholm, Sweden.

Whitney Weigel (W)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Anna Carrasco (A)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Christopher Andrew Tibbitt (CA)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Heinrich Schlums (H)

Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Ulrik Lindforss (U)

Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.

Caroline Nordenvall (C)

Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.

Malin Ljunggren (M)

Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.

Maja Ideström (M)

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Pediatric Gastroenterology, Hepatology and Nutrition Unit, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.

Mattias Svensson (M)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Jan-Inge Henter (JI)

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Theme of Children's Health, Karolinska University Hospital, Stockholm, Sweden.

Eduardo J Villablanca (EJ)

Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institutet and University Hospital, Stockholm, Sweden.

Yenan T Bryceson (YT)

Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Helena Rolandsdotter (H)

Department of Gastroenterology, Sachs' Children and Youth Hospital, Stockholm, Sweden; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.

Jenny Mjösberg (J)

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden. Electronic address: jenny.mjosberg@ki.se.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The single-cell transcriptional landscape of...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › The single-cell transcriptional landscape of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › The single-cell transcriptional landscape of...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › The single-cell transcriptional landscape of...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › The single-cell transcriptional landscape of...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › The single-cell transcriptional landscape of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › The single-cell transcriptional landscape of...