Thermosensitive
Rutin
SBE-β-cyclodextrin
dermal drug delivery systems
in situ gel
pluronic
Journal
Turkish journal of pharmaceutical sciences
ISSN: 2148-6247
Titre abrégé: Turk J Pharm Sci
Pays: Turkey
ID NLM: 101717890
Informations de publication
Date de publication:
09 May 2023
09 May 2023
Historique:
medline:
10
5
2023
pubmed:
10
5
2023
entrez:
10
5
2023
Statut:
ppublish
Résumé
Rutin has been broadly applied for treating several diseases due to its pharmacological activities. However, its low aqueous solubility limits its absorption and bioavailability. This research aims to increase the solubility of rutin using cyclodextrin and to develop a temperature-triggered The solubility of rutin was increased with sulfobutyl ether-β-cyclodextrin (SBE-β-CD). Rutin- SBE-β-CD inclusion complex was prepared by kneading and freeze dying method. Structural characterization was carried out using differential scanning calorimetry and fourier transform infrared spectroscopy. When the solubility diagrams were examined, it was concluded that SBE-β-CD showed a linear increase, therefore, AL-type diagram was selected. The formulations were produced using different amounts of PF127 and a fixed ratio of CH. Three The results indicated that the combination of PF127 and CH can be a hopeful
Identifiants
pubmed: 37161283
doi: 10.4274/tjps.galenos.2022.00334
pmc: PMC10176629
doi:
Types de publication
Journal Article
Langues
eng
Pagination
78-83Informations de copyright
©Copyright 2023 by Turkish Pharmacists' Association / Turkish Journal of Pharmaceutical Sciences published by Galenos Publishing House.
Déclaration de conflit d'intérêts
Conflict of Interest: No conflict of interest was declared by the authors.
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