Immune synaptopathies: how maternal immune activation impacts synaptic function during development.
brain-immune system cross-talk
maternal immune activation
neurodevelopmental diseases
prenatal inflammation
synapse
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
03 07 2023
03 07 2023
Historique:
revised:
23
03
2023
received:
17
02
2023
accepted:
17
04
2023
medline:
30
6
2023
pubmed:
10
5
2023
entrez:
10
5
2023
Statut:
ppublish
Résumé
In the last two decades, the term synaptopathy has been largely used to underline the concept that impairments of synaptic structure and function are the major determinant of brain disorders, including neurodevelopmental disorders. This notion emerged from the progress made in understanding the genetic architecture of neurodevelopmental disorders, which highlighted the convergence of genetic risk factors onto molecular pathways specifically localized at the synapse. However, the multifactorial origin of these disorders also indicated the key contribution of environmental factors. It is well recognized that inflammation is a risk factor for neurodevelopmental disorders, and several immune molecules critically contribute to synaptic dysfunction. In the present review, we highlight this concept, which we define by the term "immune-synaptopathy," and we discuss recent evidence suggesting a bi-directional link between the genetic architecture of individuals and maternal activation of the immune system in modulating brain developmental trajectories in health and disease.
Identifiants
pubmed: 37161785
doi: 10.15252/embj.2023113796
pmc: PMC10308362
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e113796Subventions
Organisme : Telethon
ID : GJC21044A
Pays : Italy
Organisme : European Research Council
ID : 101055323
Pays : International
Organisme : Telethon
ID : GGP19226A
Pays : Italy
Organisme : Telethon
ID : GGP20127
Pays : Italy
Informations de copyright
© 2023 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
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