GALLBLADDER POLYPS: CORRELATION AND AGREEMENT BETWEEN ULTRASONOGRAPHIC AND HISTOPATHOLOGICAL FINDINGS IN A POPULATION WITH HIGH INCIDENCE OF GALLBLADDER CANCER.
Journal
Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery
ISSN: 2317-6326
Titre abrégé: Arq Bras Cir Dig
Pays: Brazil
ID NLM: 9100283
Informations de publication
Date de publication:
2023
2023
Historique:
received:
14
08
2021
accepted:
30
06
2022
medline:
11
5
2023
pubmed:
10
5
2023
entrez:
10
5
2023
Statut:
epublish
Résumé
Gallbladder polyps are becoming a common finding in ultrasound. The management has to consider the potential risk of malignant lesions. The aim of this study was to analyze the ultrasound findings in patients undergoing cholecystectomy due to gallbladder polyps and compare them for histopathological findings (HPs). Patients with an ultrasonographic diagnosis of gallbladder polyp and who underwent cholecystectomy from 2007 to 2020 were included in the study. A total of 447 patients were included, of whom 58% were women. The mean age was 45±12 years. The mean size of polyps in US was 7.9±3.6 mm. Notably, 9% of polyps were greater than 10 mm, and single polyps were significantly larger than the multiple ones (p=0.003). Histopathological findings confirmed the presence of polyps in 88.4%, with a mean size of 4.8±3.4 mm. In all, 16 cases were neoplastic polyps (4.1%), 4 of them being malignancies, and all were single and larger than 10 mm. We found a significant correlation between ultrasound and histopathological findings polyp size determination (r=0.44; p<0.001). The Bland-Altman analysis obtained an overestimation of the US size of 3.26 mm. The receiver operating characteristic (ROC) curve analysis between both measures obtained an area under the receiver operating characteristic curve (AUC) of 0.77 (95%CI 0.74-0.81). Ultrasound polyps size larger than 10 mm had an odds ratio (OR) of 8.147 (95%CI 2.56-23.40) for the presence of adenoma and malignancy, with a likelihood ratio of 2.78. There is a positive correlation and appropriate diagnostic accuracy between ultrasound size of gallbladder polyps compared to histopathological records, with a trend to overestimate the size by about 3 mm. Neoplastic polyps are uncommon, and it correlates with size. Polyps larger than 10 mm were associated with adenoma and malignancy.
Sections du résumé
BACKGROUND
BACKGROUND
Gallbladder polyps are becoming a common finding in ultrasound. The management has to consider the potential risk of malignant lesions.
AIMS
OBJECTIVE
The aim of this study was to analyze the ultrasound findings in patients undergoing cholecystectomy due to gallbladder polyps and compare them for histopathological findings (HPs).
METHODS
METHODS
Patients with an ultrasonographic diagnosis of gallbladder polyp and who underwent cholecystectomy from 2007 to 2020 were included in the study.
RESULTS
RESULTS
A total of 447 patients were included, of whom 58% were women. The mean age was 45±12 years. The mean size of polyps in US was 7.9±3.6 mm. Notably, 9% of polyps were greater than 10 mm, and single polyps were significantly larger than the multiple ones (p=0.003). Histopathological findings confirmed the presence of polyps in 88.4%, with a mean size of 4.8±3.4 mm. In all, 16 cases were neoplastic polyps (4.1%), 4 of them being malignancies, and all were single and larger than 10 mm. We found a significant correlation between ultrasound and histopathological findings polyp size determination (r=0.44; p<0.001). The Bland-Altman analysis obtained an overestimation of the US size of 3.26 mm. The receiver operating characteristic (ROC) curve analysis between both measures obtained an area under the receiver operating characteristic curve (AUC) of 0.77 (95%CI 0.74-0.81). Ultrasound polyps size larger than 10 mm had an odds ratio (OR) of 8.147 (95%CI 2.56-23.40) for the presence of adenoma and malignancy, with a likelihood ratio of 2.78.
CONCLUSIONS
CONCLUSIONS
There is a positive correlation and appropriate diagnostic accuracy between ultrasound size of gallbladder polyps compared to histopathological records, with a trend to overestimate the size by about 3 mm. Neoplastic polyps are uncommon, and it correlates with size. Polyps larger than 10 mm were associated with adenoma and malignancy.
Identifiants
pubmed: 37162074
pii: S0102-67202023000100306
doi: 10.1590/0102-672020230002e1732
pmc: PMC10168665
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1732Références
Eur Radiol. 2017 Sep;27(9):3856-3866
pubmed: 28185005
J Gastrointest Surg. 2009 Jan;13(1):19-25
pubmed: 18972168
Langenbecks Arch Surg. 2015 May;400(4):455-62
pubmed: 25910600
Surgeon. 2014 Aug;12(4):221-6
pubmed: 24502936
Hepatobiliary Surg Nutr. 2016 Feb;5(1):85-7
pubmed: 26904562
World J Gastroenterol. 2018 Jul 14;24(26):2844-2852
pubmed: 30018479
Malays J Med Sci. 2021 Feb;28(1):27-34
pubmed: 33679217
Rev Med Chil. 2004 Jun;132(6):673-9
pubmed: 15332368
Radiographics. 2015 Mar-Apr;35(2):387-99
pubmed: 25763724
Am Surg. 2018 Oct 1;84(10):1670-1674
pubmed: 30747692
Acta Chir Belg. 2013 May-Jun;113(3):208-12
pubmed: 24941718
Int J Surg. 2016 Sep;33 Pt A:28-35
pubmed: 27465099
J Med Imaging Radiat Sci. 2021 Mar;52(1):68-78
pubmed: 33422451
Br J Surg. 1990 Apr;77(4):363-4
pubmed: 2187556
Rev Chilena Infectol. 2012 Apr;29(2):138-41
pubmed: 22689026
Surgery. 2000 Jun;127(6):622-7
pubmed: 10840356
Ann Surg. 1982 Mar;195(3):270-3
pubmed: 7059239
Korean J Gastroenterol. 2010 Feb;55(2):119-26
pubmed: 20168058
Eur J Surg Oncol. 2009 Jan;35(1):48-51
pubmed: 18339513
Cochrane Database Syst Rev. 2018 Aug 15;8:CD012233
pubmed: 30109701
JAMA Netw Open. 2020 May 1;3(5):e205143
pubmed: 32421183
PLoS One. 2020 Sep 11;15(9):e0237979
pubmed: 32915805
Arq Bras Cir Dig. 2022 Jun 17;35:e1652
pubmed: 35730881
Scand J Gastroenterol. 2021 Apr;56(4):458-462
pubmed: 33590795
J Gastrointest Surg. 2017 Nov;21(11):1804-1812
pubmed: 28695432
Diagnostics (Basel). 2021 Feb 25;11(3):
pubmed: 33668755
Can J Surg. 2018 Jun;61(3):200-207
pubmed: 29806818
Surg Endosc. 2021 Sep;35(9):5179-5185
pubmed: 32974780
Arq Bras Cir Dig. 2020 Jul 8;33(1):e1496
pubmed: 32667526
JSLS. 2020 Oct-Dec;24(4):
pubmed: 33100819
Gut Liver. 2008 Sep;2(2):88-94
pubmed: 20485616
Cancer. 1982 Nov 15;50(10):2226-34
pubmed: 7127263