T helper 2 cells in asthma.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
05 06 2023
05 06 2023
Historique:
received:
20
12
2022
revised:
10
03
2023
accepted:
25
04
2023
medline:
12
5
2023
pubmed:
10
5
2023
entrez:
10
5
2023
Statut:
ppublish
Résumé
Allergic asthma is among the most common immune-mediated diseases across the world, and type 2 immune responses are thought to be central to pathogenesis. The importance of T helper 2 (Th2) cells as central regulators of type 2 responses in asthma has, however, become less clear with the discovery of other potent innate sources of type 2 cytokines and innate mediators of inflammation such as the alarmins. This review provides an update of our current understanding of Th2 cells in human asthma, highlighting their many guises and functions in asthma, both pathogenic and regulatory, and how these are influenced by the tissue location and disease stage and severity. It also explores how biologics targeting type 2 immune pathways are impacting asthma, and how these have the potential to reveal hitherto underappreciated roles for Th2 cell in lung inflammation.
Identifiants
pubmed: 37163370
pii: 214104
doi: 10.1084/jem.20221094
pmc: PMC10174188
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023 Harker and Lloyd.
Références
Front Immunol. 2022 Aug 08;13:916778
pubmed: 36003397
J Clin Invest. 2020 Jul 1;130(7):3820-3832
pubmed: 32255767
Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13562-7
pubmed: 18768794
Science. 2006 Dec 15;314(5806):1746
pubmed: 17170297
Chest. 2010 Oct;138(4):905-12
pubmed: 20453071
World Allergy Organ J. 2022 Sep 25;15(10):100695
pubmed: 36254180
Front Immunol. 2019 Sep 27;10:2318
pubmed: 31611881
J Allergy Clin Immunol. 2020 Feb;145(2):666-678.e9
pubmed: 31445933
Immunity. 2011 Jan 28;34(1):108-21
pubmed: 21215658
J Allergy Clin Immunol. 2015 Aug;136(2):323-33
pubmed: 25746968
N Engl J Med. 2015 May 21;372(21):1987-95
pubmed: 25981191
Eur J Immunol. 2012 May;42(5):1106-16
pubmed: 22539286
Am J Respir Crit Care Med. 2005 Feb 1;171(3):224-30
pubmed: 15502111
J Allergy Clin Immunol. 2009 May;123(5):1185-7
pubmed: 19361847
Nat Rev Immunol. 2010 Dec;10(12):838-48
pubmed: 21060320
Immunity. 2000 Oct;13(4):573-83
pubmed: 11070175
Immunity. 2019 Mar 19;50(3):707-722.e6
pubmed: 30824323
Immunity. 2022 Feb 8;55(2):254-271.e7
pubmed: 35139352
Sci Immunol. 2018 Sep 7;3(27):
pubmed: 30194239
J Allergy Clin Immunol. 2018 Jun;141(6):2048-2060.e13
pubmed: 28939412
J Immunol. 2006 Oct 1;177(7):4927-32
pubmed: 16982935
Mucosal Immunol. 2014 May;7(3):501-10
pubmed: 24064670
Lancet Respir Med. 2017 May;5(5):390-400
pubmed: 28395936
Allergy. 2010 Mar;65(3):311-8
pubmed: 19845574
N Engl J Med. 2018 Jun 28;378(26):2486-2496
pubmed: 29782217
Nat Med. 2019 Jul;25(7):1153-1163
pubmed: 31209336
J Exp Med. 2005 Nov 7;202(9):1199-212
pubmed: 16275759
J Allergy Clin Immunol. 2014 Nov;134(5):1175-1186.e7
pubmed: 25042748
J Clin Invest. 2011 Nov;121(11):4503-15
pubmed: 21965331
Immunity. 2018 Oct 16;49(4):666-677.e6
pubmed: 30291029
J Clin Invest. 2015 Aug 3;125(8):3037-50
pubmed: 26121748
J Allergy Clin Immunol. 2002 Dec;110(6):899-905
pubmed: 12464957
J Immunol. 2017 Jul 1;199(1):244-252
pubmed: 28533444
Sci Transl Med. 2015 Aug 19;7(301):301ra129
pubmed: 26290411
Immunity. 2016 Feb 16;44(2):259-73
pubmed: 26825674
Nat Immunol. 2014 Aug;15(8):777-88
pubmed: 24997565
Chest. 2021 Feb;159(2):496-506
pubmed: 32882249
Adv Ther. 2018 May;35(5):737-748
pubmed: 29725983
J Allergy Clin Immunol. 2020 Sep;146(3):555-570
pubmed: 32320734
Immunity. 2012 Feb 24;36(2):175-87
pubmed: 22326582
Nature. 2023 Feb;614(7949):762-766
pubmed: 36653453
JCI Insight. 2019 Mar 21;4(6):
pubmed: 30779711
Cytokine. 2015 Sep;75(1):68-78
pubmed: 26070934
Sci Immunol. 2021 Jan 22;6(55):
pubmed: 33483337
Clin Exp Allergy. 2017 Jun;47(6):770-784
pubmed: 28000962
Nat Immunol. 2003 Mar;4(3):261-8
pubmed: 12577056
N Engl J Med. 2013 Jun 27;368(26):2455-66
pubmed: 23688323
Sci Immunol. 2020 Jun 12;5(48):
pubmed: 32532832
Immunity. 2013 Dec 12;39(6):1043-56
pubmed: 24315998
Immunol Rev. 2013 Mar;252(1):104-15
pubmed: 23405898
Immunity. 2015 Feb 17;42(2):294-308
pubmed: 25692703
Sci Immunol. 2017 Mar 10;2(9):
pubmed: 28783701
Immunity. 2012 Mar 23;36(3):451-63
pubmed: 22425247
Nat Med. 2012 May 04;18(5):716-25
pubmed: 22561835
Lancet Respir Med. 2016 Oct;4(10):781-796
pubmed: 27616196
J Immunol. 2018 Mar 1;200(5):1561-1569
pubmed: 29343554
J Immunol. 2009 Oct 15;183(8):4887-94
pubmed: 19801513
N Engl J Med. 2021 May 13;384(19):1800-1809
pubmed: 33979488
Immunity. 2019 Apr 16;50(4):975-991
pubmed: 30995510
Am J Respir Crit Care Med. 2014 Dec 15;190(12):1373-82
pubmed: 25350863
Science. 2002 Nov 22;298(5598):1630-4
pubmed: 12446913
Blood. 2018 Nov 15;132(20):2183-2187
pubmed: 30154112
J Exp Med. 2009 May 11;206(5):991-9
pubmed: 19380637
Allergy. 2020 May;75(5):1240-1243
pubmed: 31837235
Immunity. 2009 Sep 18;31(3):438-49
pubmed: 19766086
BMC Pulm Med. 2011 Feb 28;11:14
pubmed: 21356110
Nat Commun. 2021 Aug 19;12(1):5029
pubmed: 34413303
J Clin Invest. 2018 Mar 1;128(3):997-1009
pubmed: 29400693
J Exp Med. 2020 May 4;217(5):
pubmed: 32130409
Allergy Asthma Immunol Res. 2016 Nov;8(6):491-8
pubmed: 27582399
J Allergy Clin Immunol. 2012 Apr;129(4):1000-10.e3
pubmed: 22277204
N Engl J Med. 2010 Jan 7;362(1):36-44
pubmed: 20032318
Immunity. 2022 Dec 13;55(12):2352-2368.e7
pubmed: 36272417
J Exp Med. 2020 Jul 6;217(7):
pubmed: 32399548
Immunity. 2019 Jul 16;51(1):169-184.e5
pubmed: 31231035
N Engl J Med. 2011 Sep 22;365(12):1088-98
pubmed: 21812663
Mucosal Immunol. 2010 May;3(3):216-29
pubmed: 20164832
J Allergy Clin Immunol. 2021 Feb;147(2):686-693.e3
pubmed: 32526308
Sci Immunol. 2018 Jul 6;3(25):
pubmed: 29980619
J Exp Med. 2021 Dec 6;218(12):
pubmed: 34665220
J Allergy Clin Immunol. 2021 Sep;148(3):790-798
pubmed: 33872652
Trends Immunol. 2019 Oct;40(10):877-887
pubmed: 31522963
Am J Respir Crit Care Med. 2004 Feb 1;169(3):378-85
pubmed: 14597485
J Allergy Clin Immunol. 2016 Mar;137(3):907-18.e9
pubmed: 26431580
Lancet Respir Med. 2019 Jan;7(1):46-59
pubmed: 30416083
J Clin Invest. 2013 Nov;123(11):4923-34
pubmed: 24135136
N Engl J Med. 2018 Jun 28;378(26):2475-2485
pubmed: 29782224
Nat Immunol. 2018 Jul;19(7):766-775
pubmed: 29925997
J Allergy Clin Immunol Pract. 2020 Feb;8(2):516-526
pubmed: 31521831
Allergy. 2016 Aug;71(8):1086-94
pubmed: 26970097
Lancet Respir Med. 2015 May;3(5):355-66
pubmed: 25736990
Sci Transl Med. 2016 Oct 5;8(359):359ra132
pubmed: 27708065
Cell. 2016 Jan 14;164(1-2):141-155
pubmed: 26774822
J Allergy Clin Immunol. 2019 Nov;144(5):1198-1213
pubmed: 30998987
Science. 2019 May 24;364(6442):
pubmed: 31123109
J Allergy Clin Immunol. 2017 May;139(5):1548-1558.e4
pubmed: 27702673
J Allergy Clin Immunol. 2016 Sep;138(3):898-901.e4
pubmed: 27212084
Nat Immunol. 2011 Dec 04;13(1):58-66
pubmed: 22138715
Lancet Respir Med. 2015 Sep;3(9):692-701
pubmed: 26231288
Front Immunol. 2021 Jun 30;12:696784
pubmed: 34276687
Lancet Respir Med. 2018 Jul;6(7):511-525
pubmed: 29792288
J Allergy Clin Immunol. 2014 Apr;133(4):1142-8
pubmed: 24679471
J Exp Med. 2010 Oct 25;207(11):2479-91
pubmed: 20921287
J Allergy Clin Immunol. 2018 Oct;142(4):1144-1158.e8
pubmed: 29247716
Lancet Respir Med. 2022 Jan;10(1):11-25
pubmed: 34597534
J Exp Med. 2021 Dec 6;218(12):
pubmed: 34813654
Cell. 1997 May 16;89(4):587-96
pubmed: 9160750
Annu Rev Immunol. 2022 Apr 26;40:195-220
pubmed: 35044795
Lancet. 2016 Oct 29;388(10056):2115-2127
pubmed: 27609408
J Exp Med. 2019 Aug 5;216(8):1843-1856
pubmed: 31209070
Nat Immunol. 2023 Jan;24(1):123-135
pubmed: 36550322
Eur Respir J. 2019 Jan 31;53(2):
pubmed: 30442714
Mucosal Immunol. 2018 Sep;11(5):1408-1419
pubmed: 29907870
Immunity. 2011 Sep 23;35(3):337-48
pubmed: 21924928
Blood. 2002 Dec 15;100(13):4565-73
pubmed: 12393685
N Engl J Med. 2009 Mar 5;360(10):973-84
pubmed: 19264686
Sci Transl Med. 2017 Aug 2;9(401):
pubmed: 28768806
N Engl J Med. 2021 Dec 9;385(24):2230-2240
pubmed: 34879449
J Immunol. 2009 Aug 1;183(3):1598-606
pubmed: 19592658
Immunity. 2016 Jan 19;44(1):155-166
pubmed: 26750312
Am J Respir Cell Mol Biol. 2018 Feb;58(2):261-270
pubmed: 28933920
Cell. 2021 Apr 1;184(7):1775-1789.e19
pubmed: 33711260
J Immunol Res. 2022 May 10;2022:8871037
pubmed: 35592688
Lancet. 2016 Oct 29;388(10056):2128-2141
pubmed: 27609406
J Exp Med. 2005 Dec 5;202(11):1539-47
pubmed: 16314435
Clin Exp Allergy. 2016 Dec;46(12):1614-1616
pubmed: 27770456
N Engl J Med. 2017 Sep 7;377(10):936-946
pubmed: 28877011
Nat Med. 2012 Mar 04;18(4):547-54
pubmed: 22388091
Nat Rev Immunol. 2015 Jan;15(1):57-65
pubmed: 25534623
Immunol Cell Biol. 2022 Nov;100(10):791-804
pubmed: 36177669
Lancet Respir Med. 2021 Nov;9(11):1299-1312
pubmed: 34256031
Respir Res. 2013 Sep 19;14:93
pubmed: 24050312
Immunity. 2005 Jun;22(6):693-703
pubmed: 15963784
Sci Immunol. 2019 Jan 18;4(31):
pubmed: 30658968
Trends Immunol. 2021 Aug;42(8):658-669
pubmed: 34244056
J Exp Med. 2020 Sep 7;217(9):
pubmed: 32579670
J Allergy Clin Immunol. 2016 May;137(5):1514-24
pubmed: 26684290
Eur Respir J. 2019 Jan 31;53(2):
pubmed: 30760544
Am J Respir Crit Care Med. 2022 May 1;205(9):1036-1045
pubmed: 35104436
J Allergy Clin Immunol. 2017 Jan;139(1):300-313.e7
pubmed: 27325434
Immunity. 2018 Jul 17;49(1):134-150.e6
pubmed: 29958800
J Clin Invest. 2001 Dec;108(12):1817-24
pubmed: 11748265
J Exp Med. 2008 Jul 7;205(7):1551-7
pubmed: 18591410
J Immunol. 2012 Feb 1;188(3):1503-13
pubmed: 22198948
Nat Immunol. 2019 Nov;20(11):1469-1480
pubmed: 31591568
Mucosal Immunol. 2013 Mar;6(2):335-46
pubmed: 22892938
J Allergy Clin Immunol. 2018 Jun;141(6):2061-2073.e5
pubmed: 28943467
Cell Rep. 2020 Jul 7;32(1):107872
pubmed: 32640237
J Allergy Clin Immunol. 2013 Nov;132(5):1086-1096.e5
pubmed: 23866823
Immunity. 2015 Aug 18;43(2):318-30
pubmed: 26287681
Allergy. 2019 Apr;74(4):650-662
pubmed: 30220084
J Exp Med. 2009 May 11;206(5):1001-7
pubmed: 19380638
J Immunol. 2016 Feb 1;196(3):963-77
pubmed: 26729801
J Immunol. 2016 Jul 15;197(2):655-64
pubmed: 27271570
N Engl J Med. 2021 Oct 28;385(18):1656-1668
pubmed: 34706171
Immunity. 2014 Mar 20;40(3):425-35
pubmed: 24613091
Clin Exp Allergy. 2021 Aug;51(8):1057-1068
pubmed: 33938071
Annu Rev Immunol. 2021 Apr 26;39:167-198
pubmed: 33534604
Front Immunol. 2018 Jun 01;9:1211
pubmed: 29910811
Lancet. 2016 Jul 2;388(10039):31-44
pubmed: 27130691
Nat Immunol. 2019 Oct;20(10):1360-1371
pubmed: 31477921
Curr Opin Immunol. 2013 Dec;25(6):755-60
pubmed: 24035139
Science. 2019 Aug 30;365(6456):
pubmed: 31371561