Reinstating olfactory bulb-derived limbic gamma oscillations alleviates depression-like behavioral deficits in rodents.

Animals Olfactory Bulb / physiology Rodentia Depression / therapy Depressive Disorder, Major Neurons
OBx closed loop depression electrical stimulation gamma oscillation miniSOG olfactory bulb optogenetics rat

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
05 07 2023
Historique:
received: 16 03 2022
revised: 31 01 2023
accepted: 12 04 2023
medline: 10 7 2023
pubmed: 11 5 2023
entrez: 10 5 2023
Statut: ppublish

Résumé

Although the etiology of major depressive disorder remains poorly understood, reduced gamma oscillations is an emerging biomarker. Olfactory bulbectomy, an established model of depression that reduces limbic gamma oscillations, suffers from non-specific effects of structural damage. Here, we show that transient functional suppression of olfactory bulb neurons or their piriform cortex efferents decreased gamma oscillation power in limbic areas and induced depression-like behaviors in rodents. Enhancing transmission of gamma oscillations from olfactory bulb to limbic structures by closed-loop electrical neuromodulation alleviated these behaviors. By contrast, silencing gamma transmission by anti-phase closed-loop stimulation strengthened depression-like behaviors in naive animals. These induced behaviors were neutralized by ketamine treatment that restored limbic gamma power. Taken together, our results reveal a causal link between limbic gamma oscillations and depression-like behaviors in rodents. Interfering with these endogenous rhythms can affect behaviors in rodent models of depression, suggesting that restoring gamma oscillations may alleviate depressive symptoms.

Identifiants

DOI: 10.1016/j.neuron.2023.04.013 PMID: 37164008 PMC: PMC10321244
pubmed: 37164008
pii: S0896-6273(23)00298-2
doi: 10.1016/j.neuron.2023.04.013
pmc: PMC10321244
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2065-2075.e5

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests A.B. and A.J.N. are the owners of Amplipex LLC (Szeged, Hungary), a manufacturer of signal-multiplexed neuronal amplifiers. A.B. is a shareholder, chairman, and CEO; O.D. is the advisor and director; and G.B. is a shareholder of Neunos, Inc. (Boston, MA, USA), a company developing neurostimulator devices.

Auteurs

Qun Li (Q)

MTA-SZTE "Momentum" Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged 6720, Hungary; HCEMM-SZTE Magnetotherapeutics Research Group, University of Szeged, Szeged 6720, Hungary.

Yuichi Takeuchi (Y)

MTA-SZTE "Momentum" Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged 6720, Hungary; Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan; Department of Physiology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan; Department of Biopharmaceutical Sciences and Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

Jiale Wang (J)

MTA-SZTE "Momentum" Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged 6720, Hungary; Faculty of Agriculture, University of Szeged, Szeged 6720, Hungary.

Levente Gellért (L)

MTA-SZTE "Momentum" Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged 6720, Hungary; HCEMM-SZTE Magnetotherapeutics Research Group, University of Szeged, Szeged 6720, Hungary.

Livia Barcsai (L)

MTA-SZTE "Momentum" Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged 6720, Hungary; HCEMM-SZTE Magnetotherapeutics Research Group, University of Szeged, Szeged 6720, Hungary; Neunos Inc, Boston, MA 02108, USA.

Lizeth K Pedraza (LK)

MTA-SZTE "Momentum" Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged 6720, Hungary.

Anett J Nagy (AJ)

MTA-SZTE "Momentum" Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged 6720, Hungary; HCEMM-SZTE Magnetotherapeutics Research Group, University of Szeged, Szeged 6720, Hungary; Neunos Inc, Boston, MA 02108, USA.

Gábor Kozák (G)

MTA-SZTE "Momentum" Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged 6720, Hungary.

Shinya Nakai (S)

Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.

Shigeki Kato (S)

Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.

Kazuto Kobayashi (K)

Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.

Masahiro Ohsawa (M)

MTA-SZTE "Momentum" Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged 6720, Hungary; Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.

Gyöngyi Horváth (G)

Department of Physiology, University of Szeged, Szeged 6720, Hungary.

Gabriella Kékesi (G)

Department of Physiology, University of Szeged, Szeged 6720, Hungary.

Magor L Lőrincz (ML)

MTA-SZTE "Momentum" Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged 6720, Hungary; Department of Physiology, Anatomy and Neuroscience, Faculty of Sciences University of Szeged, Szeged 6726, Hungary; Neuroscience Division, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.

Orrin Devinsky (O)

Department of Neurology, NYU Langone Comprehensive Epilepsy Center, NYU Grossman School of Medicine, New York, NY 10016, USA.

György Buzsáki (G)

Neuroscience Institute, New York University, New York, NY 10016, USA.

Antal Berényi (A)

MTA-SZTE "Momentum" Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged 6720, Hungary; HCEMM-SZTE Magnetotherapeutics Research Group, University of Szeged, Szeged 6720, Hungary; Neunos Inc, Boston, MA 02108, USA; Neuroscience Institute, New York University, New York, NY 10016, USA. Electronic address: drberenyi@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Reinstating olfactory bulb-derived limbic...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Bulbe olfactif › Reinstating olfactory bulb-derived limbic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Reinstating olfactory bulb-derived limbic...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › Reinstating olfactory bulb-derived limbic...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Reinstating olfactory bulb-derived limbic...
questionsmedicales.fr › Cellules › Neurones › Reinstating olfactory bulb-derived limbic...