CB2 receptor in the CNS: From immune and neuronal modulation to behavior.
Behavior
Cannabinoid receptor 2
Endocannabinoid system
Neuroinflammation
Neuronal activity
Journal
Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
received:
30
12
2022
revised:
20
03
2023
accepted:
06
05
2023
medline:
5
6
2023
pubmed:
11
5
2023
entrez:
10
5
2023
Statut:
ppublish
Résumé
Despite low levels of cannabinoid receptor type 2 (CB2R) expression in the central nervous system in human and rodents, a growing body of evidence shows CB2R involvement in many processes at the behavioral level, through both immune and neuronal modulations. Recent in vitro and in vivo evidence have highlighted the complex role of CB2R under physiological and inflammatory conditions. Under neuroinflammatory states, its activation seems to protect the brain and its functions, making it a promising target in a wide range of neurological disorders. Here, we provide a complete and updated overview of CB2R function in the central nervous system of rodents, spanning from modulation of immune function in microglia but also in other cell types, to behavior and neuronal activity, in both physiological and neuroinflammatory contexts.
Identifiants
pubmed: 37164044
pii: S0149-7634(23)00195-1
doi: 10.1016/j.neubiorev.2023.105226
pii:
doi:
Substances chimiques
Receptor, Cannabinoid, CB2
0
Receptor, Cannabinoid, CB1
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105226Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing interests.