FIND Stroke Recovery Study (FIND): rationale and protocol for a longitudinal observational cohort study of trajectories of recovery and biomarkers poststroke.
stroke
stroke medicine
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
10 05 2023
10 05 2023
Historique:
medline:
12
5
2023
pubmed:
11
5
2023
entrez:
10
5
2023
Statut:
epublish
Résumé
Comprehensive studies mapping domain-specific trajectories of recovery after stroke and biomarkers reflecting these processes are scarce. We, therefore, initiated an exploratory prospective observational study of stroke cases with repeated evaluation, the We recruit individuals with first-ever stroke at the stroke unit at the Sahlgrenska University Hospital, Sweden, to FIND. The inclusion started early 2018 and we aim to enrol minimum 500 patients. Neurological and cognitive impairments across multiple domains are assessed using validated clinical assessment methods, advanced neuroimaging is performed and blood samples for biomarker measuring (protein, RNA and DNA) at inclusion and follow-up visits at 3 months, 6 months, 1 year, 2 years and 5 years poststroke. At baseline and at each follow-up visit, we also register clinical variables known to influence outcomes such as prestroke functioning, stroke severity, acute interventions, rehabilitation, other treatments, socioeconomic status, infections (including COVID-19) and other comorbidities. Recurrent stroke and other major vascular events are identified continuously in national registers. FIND composes a unique stroke cohort with detailed phenotyping, repetitive assessments of outcomes across multiple neurological and cognitive domains and patient-reported outcomes as well as blood and imaging biomarker profiling. Ethical approval for the FIND study has been obtained from the Regional Ethics Review Board in Gothenburg and the Swedish Ethics Review Board. The results of this exploratory study will provide novel data on the time course of recovery and biomarkers after stroke. The description of this protocol will inform the stroke research community of our ongoing study and facilitate comparisons with other data sets. The protocol is registered at http://www. gov, Study ID: NCT05708807.
Identifiants
pubmed: 37164469
pii: bmjopen-2023-072493
doi: 10.1136/bmjopen-2023-072493
pmc: PMC10173956
doi:
Substances chimiques
Biomarkers
0
Banques de données
ClinicalTrials.gov
['NCT05708807']
Types de publication
Clinical Trial Protocol
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e072493Informations de copyright
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Int Angiol. 2006 Sep;25(3):261-7
pubmed: 16878074
Sci Rep. 2022 Nov 22;12(1):20080
pubmed: 36418382
BMC Neurol. 2020 Aug 26;20(1):313
pubmed: 32847540
Can J Public Health. 1992 Jul-Aug;83 Suppl 2:S7-11
pubmed: 1468055
J Neurosci Res. 2022 May;100(5):1171-1181
pubmed: 31498491
Eur Stroke J. 2021 Mar;6(1):89-101
pubmed: 33817339
Lancet. 1991 Jun 22;337(8756):1521-6
pubmed: 1675378
Thromb Haemost. 2013 Dec;110(6):1305-6
pubmed: 24048512
Arch Phys Med Rehabil. 2003 Jul;84(7):950-63
pubmed: 12881816
J Gerontol. 1992 May;47(3):P154-8
pubmed: 1573197
Cerebrovasc Dis. 2022 Oct 24;:1-26
pubmed: 36279857
Cereb Circ Cogn Behav. 2022 Jan 22;3:100042
pubmed: 36324404
Alzheimers Dement (Amst). 2021 Feb 05;13(1):e12144
pubmed: 33598528
Neurorehabil Neural Repair. 2017 Oct-Nov;31(10-11):864-876
pubmed: 29233071
Stroke. 2021 Jan;52(2):543-551
pubmed: 33430636
J Neurol. 2016 Feb;263(2):306-315
pubmed: 26588918
Stroke. 2016 Sep;47(9):2427-34
pubmed: 27515845
J Am Heart Assoc. 2022 Aug 16;11(16):e025425
pubmed: 35929466
Int J Stroke. 2019 Oct;14(8):774-782
pubmed: 31514685
Eur Stroke J. 2021 Dec;6(4):428-437
pubmed: 35342816
Eur J Neurol. 2010 Feb;17(2):219-25
pubmed: 19682061
J Neuroeng Rehabil. 2021 Nov 8;18(1):162
pubmed: 34749752
BMC Neurol. 2016 May 27;16:80
pubmed: 27411309
Neurorehabil Neural Repair. 2017 Sep;31(9):784-792
pubmed: 28934918
Behav Brain Res. 2018 Mar 15;340:94-101
pubmed: 27531500
J Neurol. 2019 Nov;266(11):2796-2806
pubmed: 31375988
J Geriatr Psychiatry Neurol. 2022 May;35(3):374-381
pubmed: 33858238
Stroke. 2022 Sep;53(9):2847-2858
pubmed: 35686557
Int J Stroke. 2022 Mar;17(3):260-268
pubmed: 33739214
Acta Psychiatr Scand. 1983 Jun;67(6):361-70
pubmed: 6880820
Appl Neuropsychol. 2004;11(4):218-21
pubmed: 15673495
Eur Stroke J. 2022 Dec;7(4):476-486
pubmed: 36478766
Stroke. 2005 Dec;36(12):2670-5
pubmed: 16254227
J Consult Psychol. 1955 Oct;19(5):393-4
pubmed: 13263471
Neurorehabil Neural Repair. 2008 Mar-Apr;22(2):173-9
pubmed: 17876069
Stroke. 2021 Aug;52(9):3013-3024
pubmed: 34399587
Stroke. 2022 Apr;53(4):1318-1327
pubmed: 34775838
Ann Neurol. 2005 Nov;58(5):688-97
pubmed: 16240340
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
J Int Neuropsychol Soc. 2018 Feb;24(2):117-127
pubmed: 28791943
Neurology. 2021 Apr 13;96(15):e1966-e1974
pubmed: 33632803
Int J Stroke. 2015 Aug;10(6):893-6
pubmed: 24165205
Sci Rep. 2022 May 12;12(1):7816
pubmed: 35551206
Int J Stroke. 2017 Jul;12(5):444-450
pubmed: 28697708
Front Cardiovasc Med. 2022 Jun 22;9:896846
pubmed: 35811734
Arch Phys Med Rehabil. 2003 Oct;84(10):1499-504
pubmed: 14586918
Stroke. 2009 Jul;40(7):2473-9
pubmed: 19461036
Stroke. 2005 Jul;36(7):1383-7
pubmed: 15933254
Qual Life Res. 2002 May;11(3):263-72
pubmed: 12074263
Neurorehabil Neural Repair. 2021 Jul;35(7):585-600
pubmed: 34027728
BMC Neurol. 2014 Mar 22;14:55
pubmed: 24655479
Neuromolecular Med. 2019 Dec;21(4):344-368
pubmed: 30830566
Stroke. 2021 Aug;52(8):e499-e516
pubmed: 34039035
Arch Phys Med Rehabil. 2007 Oct;88(10):1314-9
pubmed: 17908575
Stroke. 1993 Jan;24(1):35-41
pubmed: 7678184
Acta Neurol Scand. 2022 Sep;146(3):295-303
pubmed: 35791041
Clin Rehabil. 2003 Mar;17(2):158-66
pubmed: 12625656
Thromb Haemost. 2016 Aug 30;116(3):537-43
pubmed: 27357914
Lancet Neurol. 2019 May;18(5):459-480
pubmed: 30879893
Stroke. 2007 Apr;38(4):1384-6
pubmed: 17322093
J Rehabil Med. 2019 Oct 4;51(9):660-664
pubmed: 31478056
Lancet Neurol. 2021 Oct;20(10):795-820
pubmed: 34487721
Int J Rehabil Res. 2015 Jun;38(2):173-80
pubmed: 25603539
Stroke. 2012 Oct;43(10):2592-7
pubmed: 22858729