Metallothionein-3:
Cu homeostasis
Cu-thiolate clusters
ESI-MS
Zn homeostasis
metallothionein-3
phosphorescence spectroscopy
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
revised:
25
04
2023
received:
15
03
2023
accepted:
09
05
2023
medline:
11
9
2023
pubmed:
11
5
2023
entrez:
11
5
2023
Statut:
ppublish
Résumé
Human metallothioneins (MTs) are involved in binding the essential elements, Cu(I) and Zn(II), and the toxic element, Cd(II), in metal-thiolate clusters using 20 reduced cysteines. The brain-specific MT3 binds a mixture of Cu(I) and Zn(II) in vivo. Its metallation properties are critically important because of potential connections between Cu, Zn and neurodegenerative diseases. We report that the use of isotopically pure
Substances chimiques
Metallothionein 3
0
Copper
789U1901C5
Metals
0
Metallothionein
9038-94-2
Zinc
J41CSQ7QDS
Cadmium
00BH33GNGH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4316-4341Informations de copyright
© 2023 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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