Modulation of Smooth Muscle Cell Phenotype for Translation of Tissue-Engineered Vascular Grafts.
atherosclerosis
coronary artery disease
growth factors
scaffolds
smooth muscle cell phenotype
vascular grafts
Journal
Tissue engineering. Part B, Reviews
ISSN: 1937-3376
Titre abrégé: Tissue Eng Part B Rev
Pays: United States
ID NLM: 101466660
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
pmc-release:
01
10
2024
medline:
3
11
2023
pubmed:
11
5
2023
entrez:
11
5
2023
Statut:
ppublish
Résumé
Translation of small-diameter tissue-engineered vascular grafts (TEVGs) for the treatment of coronary artery disease (CAD) remains an unfulfilled promise. This is largely due to the limited integration of TEVGs into the native vascular wall-a process hampered by the insufficient smooth muscle cell (SMC) infiltration and extracellular matrix deposition, and low vasoactivity. These processes can be promoted through the judicious modulation of the SMC toward a synthetic phenotype to promote remodeling and vascular integration; however, the expression of synthetic markers is often accompanied by a decrease in the expression of contractile proteins. Therefore, techniques that can precisely modulate the SMC phenotypical behavior could have the potential to advance the translation of TEVGs. In this review, we describe the phenotypic diversity of SMCs and the different environmental cues that allow the modulation of SMC gene expression. Furthermore, we describe the emerging biomaterial approaches to modulate the SMC phenotype in TEVG design and discuss the limitations of current techniques. In addition, we found that current studies in tissue engineering limit the analysis of the SMC phenotype to a few markers, which are often the characteristic of early differentiation only. This limited scope has reduced the potential of tissue engineering to modulate the SMC toward specific behaviors and applications. Therefore, we recommend using the techniques presented in this review, in addition to modern single-cell proteomics analysis techniques to comprehensively characterize the phenotypic modulation of SMCs. Expanding the holistic potential of SMC modulation presents a great opportunity to advance the translation of living conduits for CAD therapeutics.
Identifiants
pubmed: 37166394
doi: 10.1089/ten.TEB.2023.0006
pmc: PMC10618830
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
574-588Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL159475
Pays : United States
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