In vitro quality of cold and delayed cold-stored platelet concentrates from interim platelet units during storage for 21 days.
blood component storage
cold-stored platelets
delayed cold-stored platelets
interim platelet units
platelet concentrate
Journal
Vox sanguinis
ISSN: 1423-0410
Titre abrégé: Vox Sang
Pays: England
ID NLM: 0413606
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
revised:
13
04
2023
received:
05
01
2023
accepted:
20
04
2023
medline:
16
6
2023
pubmed:
11
5
2023
entrez:
11
5
2023
Statut:
ppublish
Résumé
Based on previous success using apheresis platelets, we wanted to investigate the in vitro quality and platelet function in continuously cold-stored and delayed cold-stored platelet concentrates (PCs) from interim platelet units (IPUs) produced by the Reveos system. We used a pool-and-split design to prepare 18 identical pairs of PCs. One unit was stored unagitated and refrigerated after production on day 1 (cold-stored). The other unit was stored agitated at room temperature until day 5 and then refrigerated (delayed cold-stored). Samples were taken after pool-and-split on day 1 and on days 5, 7, 14 and 21. Swirling was observed and haematology parameters, metabolism, blood gas, platelet activation and platelet aggregation were analysed for each sample point. All PCs complied with European recommendations (EDQM 20th edition). Both groups had mean platelet content >200 × 10 Our findings suggest that PCs from IPUs are suitable for cold storage from day 1 until day 21 and delayed cold storage from day 5 until day 14.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Based on previous success using apheresis platelets, we wanted to investigate the in vitro quality and platelet function in continuously cold-stored and delayed cold-stored platelet concentrates (PCs) from interim platelet units (IPUs) produced by the Reveos system.
MATERIALS AND METHODS
METHODS
We used a pool-and-split design to prepare 18 identical pairs of PCs. One unit was stored unagitated and refrigerated after production on day 1 (cold-stored). The other unit was stored agitated at room temperature until day 5 and then refrigerated (delayed cold-stored). Samples were taken after pool-and-split on day 1 and on days 5, 7, 14 and 21. Swirling was observed and haematology parameters, metabolism, blood gas, platelet activation and platelet aggregation were analysed for each sample point.
RESULTS
RESULTS
All PCs complied with European recommendations (EDQM 20th edition). Both groups had mean platelet content >200 × 10
CONCLUSION
CONCLUSIONS
Our findings suggest that PCs from IPUs are suitable for cold storage from day 1 until day 21 and delayed cold storage from day 5 until day 14.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
463-470Subventions
Organisme : Department of Immunology and Transfusion Medicine at Haukeland University Hospital
Informations de copyright
© 2023 International Society of Blood Transfusion.
Références
Dillard GH, Brecher G, Cronkite EP. Separation, concentration, and transfusion of platelets. Proc Soc Exp Biol Med. 1951;78:796-9.
Kattlove HE. Platelet preservation - what temperature? A rationale for strategy. Transfusion. 1974;14:328-30.
Valeri CR. Circulation and hemostatic effectiveness of platelets stored at 4 C or 22 C: studies in aspirin-treated normal volunteers. Transfusion. 1976;16:20-3.
Silva VA, Miller WV. Platelet transfusion survey in a regional blood program. Transfusion. 1977;17:255-60.
Fung MK, Eder AF, Spitalnik SL, Westhoff CM, editors. Technical manual. 19th ed. Bethesda, MD: AABB; 2017.
ECPAoBT (CD-P-TS). Guide to the preparation, use and quality assurance of blood components. 20th ed. Strasbourg, France: European Directorate for the Quality of Medicines & HealthCare; 2020.
Wood B, Johnson L, Hyland RA, Marks DC. Maximising platelet availability by delaying cold storage. Vox Sang. 2018;113:403-11.
Braathen H, Sivertsen J, Lunde THF, Kristoffersen EK, Assmus J, Hervig TA, et al. In vitro quality and platelet function of cold and delayed cold storage of apheresis platelet concentrates in platelet additive solution for 21 days. Transfusion. 2019;59:2652-61.
Stolla M, Bailey SL, Fang L, Fitzpatrick L, Gettinger I, Pellham E, et al. Effects of storage time prolongation on in vivo and in vitro characteristics of 4°C-stored platelets. Transfusion. 2020;60:613-21.
Ng MSY, Tung JP, Fraser JF. Platelet storage lesions: what more do we know now? Transfus Med Rev. 2018;32:144-54.
Bynum JA, Meledeo MA, Getz TM, Rodriguez AC, Aden JK, Cap AP, et al. Bioenergetic profiling of platelet mitochondria during storage: 4°C storage extends platelet mitochondrial function and viability. Transfusion. 2016;56:S76-84.
Ketter P, Arulanandam B, Cap AP. Platelets feeding bacteria with lactate during room temperature storage: mitigated by refrigeration. Blood. 2017;130:2407.
Ketter PM, Kamucheka R, Arulanandam B, Akers K, Cap AP. Platelet enhancement of bacterial growth during room temperature storage: mitigation through refrigeration. Transfusion. 2019;59:1479-89.
Reddoch-Cardenas KM, Peltier GC, Chance TC, Nair PM, Meledeo MA, Ramasubramanian AK, et al. Cold storage of platelets in platelet additive solution maintains mitochondrial integrity by limiting initiation of apoptosis-mediated pathways. Transfusion. 2021;61:178-90.
Zhao HW, Serrano K, Stefanoni D, D'Alessandro A, Devine DV. In vitro characterization and metabolomic analysis of cold-stored platelets. J Proteome Res. 2021;20:2251-65.
McCullough J. Overview of platelet transfusion. Semin Hematol. 2010;47:235-42.
Warner MA, Kurian EB, Hammel SA, van Buskirk CM, Kor DJ, Stubbs JR. Transition from room temperature to cold-stored platelets for the preservation of blood inventories during the COVID-19 pandemic. Transfusion. 2021;61:72-7.
Strandenes GSJ, Bjerkvig CK, Fosse TK, Cap AP, Del Junco DJ, Kristoffersen EK, et al. A pilot trial of platelets stored cold versus at room temperature for complex cardiothoracic surgery. Anesthesiology. 2020;133:1173-83.
Braathen H, Hagen KG, Kristoffersen EK, Strandenes G, Apelseth TO. Implementation of a dual platelet inventory in a tertiary hospital during the COVID-19 pandemic enabling cold-stored apheresis platelets for treatment of actively bleeding patients. Transfusion. 2022;62:S193-202.
Schubert PC, Culibrk B, Zhao W, Devine D, McTaggart K. Impact of cold storage delay time on cold stored platelet quality. Transfusion. 2018;58:143A.
Marini I, Aurich K, Jouni R, Nowak-Harnau S, Hartwich O, Greinacher A, et al. Cold storage of platelets in additive solution: the impact of residual plasma in apheresis platelet concentrates. Haematologica. 2019;104:207-14.
R Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2021. https://www.R-project.org/
Pinheiro J, Bates D, DebRoy S, Sarkar D. nlme: linear and nonlinear mixed effects models. R package version 3.1-153. Vienna, Austria: R Foundation for Statistical Computing; 2021. https://CRAN.R-project.org/package=nlme
Johnson L, Schubert P, Tan S, Devine DV, Marks DC. Extended storage and glucose exhaustion are associated with apoptotic changes in platelets stored in additive solution. Transfusion. 2016;56:360-8.
Zhang JG, Carter CJ, Culibrk B, Devine DV, Levin E, Scammell K, et al. Buffy-coat platelet variables and metabolism during storage in additive solutions or plasma. Transfusion. 2008;48:847-56.
Gulliksson H. Platelet storage media. Vox Sang. 2014;107:205-12.
Andrews RK, Berndt MC. Platelet physiology: in cold blood. Curr Biol. 2003;13:R282-4.
van der Wal DE, Gitz E, Du VX, Lo KS, Koekman CA, Versteeg S, et al. Arachidonic acid depletion extends survival of cold-stored platelets by interfering with the [glycoprotein Ibα-14-3-3ζ] association. Haematologica. 2012;97:1514-22.
Tohidi-Esfahani I, Tan S, Tan CW, Johnson L, Marks DC, Chen VM. Platelet procoagulant potential is reduced in platelet concentrates ex vivo but appears restored following transfusion. Transfusion. 2021;61:3420-31.
Johnson L, Tan S, Wood B, Davis A, Marks DC. Refrigeration and cryopreservation of platelets differentially affect platelet metabolism and function: a comparison with conventional platelet storage conditions. Transfusion. 2016;56:1807-18.
Koessler J, Klingler P, Niklaus M, Weber K, Koessler A, Boeck M, et al. The impact of cold storage on adenosine diphosphate-mediated platelet responsiveness. TH Open. 2020;4:e163-72.
Stanworth SJ, New HV, Apelseth TO, Brunskill S, Cardigan R, Doree C, et al. Effects of the COVID-19 pandemic on supply and use of blood for transfusion. Lancet Haematol. 2020;7:e756-64.
Shopsowitz KE, Lim C, Shih AW, Fishbane N, Berry BR, Bigham M, et al. Impacts of COVID-19 and elective surgery cancellations on platelet supply and utilization in the Canadian Province of British Columbia. Vox Sang. 2021;117:251-8.
Apelseth TO, Cap AP, Spinella PC, Hervig T, Strandenes G. Cold stored platelets in treatment of bleeding. ISBT Sci Ser. 2017;12:488-95.