Effect of Obesity on Left Ventricular Systolic and Diastolic Functions Based on Echocardiographic Indices.
cardiovascular disease
cardiovascular imaging
diastolic function
left ventricular dysfunction
obesity
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
16
09
2022
accepted:
06
04
2023
medline:
12
5
2023
pubmed:
12
5
2023
entrez:
11
5
2023
Statut:
epublish
Résumé
Left ventricular systolic and diastolic functions are known prognosticators for cardiovascular morbidity. One of the significant risk factors for cardiovascular diseases is obesity. The objective of this study is to determine the effect of obesity on the systolic and diastolic functions of the left ventricle on the basis of echocardiographic indices. 75 obese and 75 averagely built subjects were studied. They had no other comorbidities. The indices of echocardiography of systolic and diastolic function were taken and assessed using recent recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. The volume indices of systolic and diastolic function (ejection diastolic volume (EDV) and ejection systolic volume (ESV)) and iso-volumetric relaxation time (IVRT) showed a significant increase in obese subjects (p<0.05); however, the relative thickness of the wall and internal diameter were comparable to non-obese subjects. The indices of contractility like ejection fraction, early diastolic filling velocity and late diastolic filling velocity (E/A) ratio, and mitral annular velocity were significantly lower in the obese subjects as compared to non-obese subjects. It was also found that left atrial diameter in systole and diastole had a moderate association (r=0.48, P<0.0001; r=0.35, P<0.0005) while mitral inflow E/A ratio had a negative association with body mass index (BMI) (r=-0.26, P=0.0166). Volumetric changes and ejection are significantly altered by increased BMI. More comprehensive studies in the future are recommended to assess the same.
Sections du résumé
BACKGROUND
BACKGROUND
Left ventricular systolic and diastolic functions are known prognosticators for cardiovascular morbidity. One of the significant risk factors for cardiovascular diseases is obesity. The objective of this study is to determine the effect of obesity on the systolic and diastolic functions of the left ventricle on the basis of echocardiographic indices.
METHODS
METHODS
75 obese and 75 averagely built subjects were studied. They had no other comorbidities. The indices of echocardiography of systolic and diastolic function were taken and assessed using recent recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography.
RESULTS
RESULTS
The volume indices of systolic and diastolic function (ejection diastolic volume (EDV) and ejection systolic volume (ESV)) and iso-volumetric relaxation time (IVRT) showed a significant increase in obese subjects (p<0.05); however, the relative thickness of the wall and internal diameter were comparable to non-obese subjects. The indices of contractility like ejection fraction, early diastolic filling velocity and late diastolic filling velocity (E/A) ratio, and mitral annular velocity were significantly lower in the obese subjects as compared to non-obese subjects. It was also found that left atrial diameter in systole and diastole had a moderate association (r=0.48, P<0.0001; r=0.35, P<0.0005) while mitral inflow E/A ratio had a negative association with body mass index (BMI) (r=-0.26, P=0.0166).
CONCLUSIONS
CONCLUSIONS
Volumetric changes and ejection are significantly altered by increased BMI. More comprehensive studies in the future are recommended to assess the same.
Identifiants
pubmed: 37168145
doi: 10.7759/cureus.37232
pmc: PMC10166396
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e37232Informations de copyright
Copyright © 2023, Gade et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Int J Cardiol. 2019 Feb 15;277:147-152
pubmed: 30097335
Metabolism. 2022 Aug;133:155217
pubmed: 35584732
Indian J Med Res. 2015 Aug;142(2):139-50
pubmed: 26354211
Circ Heart Fail. 2015 Sep;8(5):897-904
pubmed: 26175540
Diabetes Care. 2002 Jun;25(6):1042-8
pubmed: 12032112
J Am Coll Cardiol. 2001 Mar 15;37(4):1042-8
pubmed: 11263606
J Am Coll Cardiol. 2002 Jun 19;39(12):2005-11
pubmed: 12084601
Am J Cardiol. 2001 Nov 15;88(10):1163-8
pubmed: 11703964
Curr Opin Cardiol. 2021 Jul 1;36(4):453-460
pubmed: 33929365
N Engl J Med. 2002 Aug 1;347(5):305-13
pubmed: 12151467
Obes Res. 2004 Oct;12(10):1616-21
pubmed: 15536225
J Clin Diagn Res. 2013 Aug;7(8):1599-603
pubmed: 24086850
Lancet. 2004 Jan 10;363(9403):157-63
pubmed: 14726171
Metab Syndr Relat Disord. 2009 Apr;7(2):151-8
pubmed: 19284312
J Assoc Physicians India. 2016 Feb;64(2):20-26
pubmed: 27730776
Am J Cardiol. 2004 Oct 15;94(8):1087-90
pubmed: 15476635
J Am Soc Echocardiogr. 2016 Apr;29(4):277-314
pubmed: 27037982
Am J Cardiol. 1991 Jul 1;68(1):95-8
pubmed: 1829321
Hypertension. 1994 May;23(5):600-6
pubmed: 8175168
Am J Med Sci. 2001 Apr;321(4):225-36
pubmed: 11307864
Heart. 2003 Oct;89(10):1152-6
pubmed: 12975404
Arch Intern Med. 2007 Sep 10;167(16):1720-8
pubmed: 17846390
JAMA. 2003 Jan 8;289(2):194-202
pubmed: 12517230
Circulation. 2004 Nov 9;110(19):3081-7
pubmed: 15520317
J Am Coll Cardiol. 2000 Sep;36(3):891-6
pubmed: 10987616
Curr Obes Rep. 2016 Dec;5(4):424-434
pubmed: 27744513
Clin Med Insights Cardiol. 2013;7:43-50
pubmed: 23471126
Eur J Heart Fail. 2016 Mar;18(3):242-52
pubmed: 26727047
JACC Cardiovasc Imaging. 2010 Mar;3(3):266-74
pubmed: 20223423
J Am Coll Cardiol. 2004 Apr 21;43(8):1399-404
pubmed: 15093874