Evaluating the transcriptional landscape and cell-cell communication networks in chronically irradiated parotid glands.
Cell biology
Immunology
Transcriptomics
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
19 May 2023
19 May 2023
Historique:
received:
25
09
2022
revised:
21
03
2023
accepted:
07
04
2023
medline:
12
5
2023
pubmed:
12
5
2023
entrez:
11
5
2023
Statut:
epublish
Résumé
Understanding the transcriptional landscape that results in chronic salivary hypofunction after irradiation will help identify injury mechanisms and develop regenerative therapies. We present scRNA-seq analysis from control and irradiated murine parotid glands collected 10 months after irradiation. We identify a population of secretory cells defined by specific expression of
Identifiants
pubmed: 37168562
doi: 10.1016/j.isci.2023.106660
pii: S2589-0042(23)00737-X
pmc: PMC10165028
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106660Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE029166
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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