The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor.
CRLF3
EPO
EV-3
IPSC
apoptosis
cytokine receptor
erythropoietin
neuroprotection
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
01
2023
accepted:
15
03
2023
medline:
12
5
2023
pubmed:
12
5
2023
entrez:
11
5
2023
Statut:
epublish
Résumé
The evolutionary conserved orphan cytokine receptor-like factor 3 (CRLF3) has been implicated in human disease, vertebrate hematopoiesis and insect neuroprotection. While its specific functions are elusive, experimental evidence points toward a general role in cell homeostasis. Erythropoietin (Epo) is a major regulator of vertebrate hematopoiesis and a general cytoprotective cytokine. Erythropoietic functions mediated by classical Epo receptor are understood in great detail whereas Epo-mediated cytoprotective mechanisms are more complex due to involvement of additional Epo receptors and a non-erythropoietic splice variant with selectivity for certain receptors. In the present study, we show that the human CRLF3 mediates neuroprotection upon activation with the natural Epo splice variant EV-3. We generated
Identifiants
pubmed: 37168680
doi: 10.3389/fnmol.2023.1154509
pmc: PMC10165946
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1154509Informations de copyright
Copyright © 2023 Knorr, Rodriguez Polo, Pies, Schwedhelm-Domeyer, Pauls, Behr and Heinrich.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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