ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain.


Journal

Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671

Informations de publication

Date de publication:
06 2023
Historique:
received: 09 08 2019
accepted: 11 04 2023
medline: 8 6 2023
pubmed: 12 5 2023
entrez: 11 5 2023
Statut: ppublish

Résumé

Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized by the expression of specific proteins constitute subtypes with distinct functions has not been fully elucidated. Here we describe a microglial subtype expressing the enzyme arginase-1 (ARG1; that is, ARG1

Identifiants

pubmed: 37169859
doi: 10.1038/s41593-023-01326-3
pii: 10.1038/s41593-023-01326-3
pmc: PMC10244174
doi:

Substances chimiques

Arginase EC 3.5.3.1
Arg1 protein, mouse EC 3.5.3.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1008-1020

Informations de copyright

© 2023. The Author(s).

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Auteurs

Vassilis Stratoulias (V)

Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden. vassilis.stratoulias@ki.se.
Neuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland. vassilis.stratoulias@ki.se.

Rocío Ruiz (R)

Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain.

Shigeaki Kanatani (S)

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

Ahmed M Osman (AM)

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Lily Keane (L)

Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.

Jose A Armengol (JA)

Department of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain.

Antonio Rodríguez-Moreno (A)

Department of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain.

Adriana-Natalia Murgoci (AN)

Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.

Irene García-Domínguez (I)

Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain.

Isabel Alonso-Bellido (I)

Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain.

Fernando González Ibáñez (F)

Department of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada.
Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.

Katherine Picard (K)

Department of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada.
Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.

Guillermo Vázquez-Cabrera (G)

Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.
Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain.

Mercedes Posada-Pérez (M)

Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.
Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain.

Nathalie Vernoux (N)

Department of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada.

Dario Tejera (D)

Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany.

Kathleen Grabert (K)

Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.

Mathilde Cheray (M)

Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.

Patricia González-Rodríguez (P)

Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.

Eva M Pérez-Villegas (EM)

Department of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain.

Irene Martínez-Gallego (I)

Department of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain.

Alejandro Lastra-Romero (A)

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

David Brodin (D)

Bioinformatics and Expression Analysis Core Facility, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.

Javier Avila-Cariño (J)

Department of Molecular Biology and Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.

Yang Cao (Y)

Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.
Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Mikko Airavaara (M)

Neuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.
Faculty of Pharmacy, Drug Research Program, University of Helsinki, Helsinki, Finland.

Per Uhlén (P)

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

Michael T Heneka (MT)

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA.

Marie-Ève Tremblay (MÈ)

Department of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada.
Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.

Klas Blomgren (K)

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Department of Paediatric Oncology, Karolinska University Hospital, Stockholm, Sweden.

Jose L Venero (JL)

Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain.

Bertrand Joseph (B)

Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden. bertrand.joseph@ki.se.

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