Low-dimensional organization of global brain states of reduced consciousness.

Humans Consciousness Brain Wakefulness Brain Injuries Neural Pathways Magnetic Resonance Imaging Brain Mapping
CP: Neuroscience deep learning fMRI low-dimensional brain dynamics reduced consciousness variational autoencoders whole-brain modeling

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
30 05 2023
Historique:
received: 23 11 2022
revised: 19 03 2023
accepted: 24 04 2023
medline: 5 6 2023
pubmed: 12 5 2023
entrez: 12 5 2023
Statut: ppublish

Résumé

Brain states are frequently represented using a unidimensional scale measuring the richness of subjective experience (level of consciousness). This description assumes a mapping between the high-dimensional space of whole-brain configurations and the trajectories of brain states associated with changes in consciousness, yet this mapping and its properties remain unclear. We combine whole-brain modeling, data augmentation, and deep learning for dimensionality reduction to determine a mapping representing states of consciousness in a low-dimensional space, where distances parallel similarities between states. An orderly trajectory from wakefulness to patients with brain injury is revealed in a latent space whose coordinates represent metrics related to functional modularity and structure-function coupling, increasing alongside loss of consciousness. Finally, we investigate the effects of model perturbations, providing geometrical interpretation for the stability and reversibility of states. We conclude that conscious awareness depends on functional patterns encoded as a low-dimensional trajectory within the vast space of brain configurations.

Identifiants

DOI: 10.1016/j.celrep.2023.112491 PMID: 37171963
pubmed: 37171963
pii: S2211-1247(23)00502-8
doi: 10.1016/j.celrep.2023.112491
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

112491

Subventions

Organisme : NIA NIH HHS
ID : R01 AG057234
Pays : United States

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Yonatan Sanz Perl (YS)

Department of Physics, University of Buenos Aires, Intendente Guiraldes 2160 (Ciudad Universitaria), Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), CABA, Buenos Aires, Argentina; Cognitive Neuroscience Center (CNC), Universidad de San Andrés, Buenos Aires, Argentina; Center for Brain and Cognition, Computational Neuroscience Group, Universitat Pompeu Fabra, Barcelona, Spain; Paris Brain Institute (ICM), Paris, France. Electronic address: yonatan.sanz@upf.edu.

Carla Pallavicini (C)

Department of Physics, University of Buenos Aires, Intendente Guiraldes 2160 (Ciudad Universitaria), Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), CABA, Buenos Aires, Argentina; Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Buenos Aires, Argentina.

Juan Piccinini (J)

Department of Physics, University of Buenos Aires, Intendente Guiraldes 2160 (Ciudad Universitaria), Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), CABA, Buenos Aires, Argentina.

Athena Demertzi (A)

Physiology of Cognition Research Lab, GIGA CRC-In Vivo Imaging Center, GIGA Institute, University of Liège, Liège, Belgium.

Vincent Bonhomme (V)

Anesthesia and Intensive Care Laboratory, GIGA-Consciousness, GIGA Institute, University of Liège, Liège, Belgium; University Department of Anesthesia and Intensive Care Medicine, Centre Hospitalier Régional de la Citadelle (CHR Citadelle), Liège, Belgium; Department of Anesthesia and Intensive Care Medicine, Centre Hospitalier Universitaire de Liège (CHU Liège), Liège, Belgium.

Charlotte Martial (C)

Coma Science Group, GIGA Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau(2), Centre Hospitalier Universitaire de Liège (CHU Liège), Liège, Belgium.

Rajanikant Panda (R)

Coma Science Group, GIGA Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau(2), Centre Hospitalier Universitaire de Liège (CHU Liège), Liège, Belgium.

Naji Alnagger (N)

Coma Science Group, GIGA Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau(2), Centre Hospitalier Universitaire de Liège (CHU Liège), Liège, Belgium.

Jitka Annen (J)

Coma Science Group, GIGA Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau(2), Centre Hospitalier Universitaire de Liège (CHU Liège), Liège, Belgium.

Olivia Gosseries (O)

Coma Science Group, GIGA Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau(2), Centre Hospitalier Universitaire de Liège (CHU Liège), Liège, Belgium.

Agustin Ibañez (A)

National Scientific and Technical Research Council (CONICET), CABA, Buenos Aires, Argentina; Cognitive Neuroscience Center (CNC), Universidad de San Andrés, Buenos Aires, Argentina; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile; Global Brain Health Institute (GBHI), University of California-San Francisco (UCSF), San Francisco, CA, USA; Trinity College, Dublin, Ireland.

Helmut Laufs (H)

Department of Neurology and Brain Imaging Center, Goethe University, Frankfurt am Main, Germany; Department of Neurology, Christian Albrechts University, Kiel, Germany.

Jacobo D Sitt (JD)

Paris Brain Institute (ICM), Paris, France; INSERM U 1127, Paris, France; CNRS UMR 7225, Paris, France.

Viktor K Jirsa (VK)

Institut de Neurosciences des Systèmes, Aix Marseille Université, Marseille, France.

Morten L Kringelbach (ML)

Department of Psychiatry, University of Oxford, Oxford, UK; Center for Music in the Brain, Department of Clinical Medicine, Aarhus University, Århus, Denmark; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; Centre for Eudaimonia and Human Flourishing, University of Oxford, Oxford, UK.

Steven Laureys (S)

Coma Science Group, GIGA Consciousness, University of Liège, Liège, Belgium; Centre du Cerveau(2), Centre Hospitalier Universitaire de Liège (CHU Liège), Liège, Belgium.

Gustavo Deco (G)

Center for Brain and Cognition, Computational Neuroscience Group, Universitat Pompeu Fabra, Barcelona, Spain; Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain; Institució Catalana de la Recerca i Estudis Avancats (ICREA), Barcelona, Spain.

Enzo Tagliazucchi (E)

Department of Physics, University of Buenos Aires, Intendente Guiraldes 2160 (Ciudad Universitaria), Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), CABA, Buenos Aires, Argentina; Centre du Cerveau(2), Centre Hospitalier Universitaire de Liège (CHU Liège), Liège, Belgium. Electronic address: tagliazucchi.enzo@googlemail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Low-dimensional organization of global brain...
questionsmedicales.fr › Phénomènes psychologiques › Conscience › Low-dimensional organization of global brain...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Low-dimensional organization of global brain...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Éveil › Vigilance › Low-dimensional organization of global brain...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Low-dimensional organization of global brain...
questionsmedicales.fr › Système nerveux › Voies nerveuses › Low-dimensional organization of global brain...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Low-dimensional organization of global brain...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Low-dimensional organization of global brain...