Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
12 05 2023
Historique:
medline: 15 5 2023
pubmed: 12 5 2023
entrez: 12 5 2023
Statut: ppublish

Résumé

Mirror movements (MM) disorder is characterized by involuntary movements on one side of the body that mirror intentional movements on the opposite side. We performed genetic characterization of a family with autosomal dominant MM and identified

Identifiants

pubmed: 37172092
doi: 10.1126/sciadv.add5501
pmc: PMC10181192
doi:

Substances chimiques

DCC Receptor 0
Tumor Suppressor Proteins 0
Nerve Growth Factors 0
Netrin-1 158651-98-0
Receptors, Cell Surface 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadd5501

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM128786
Pays : United States

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Auteurs

Sabrina Schlienger (S)

Montreal Clinical Research Institute (IRCM), 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada.
Department of Anatomy and Cell Biology, Division of Experimental Medicine, McGill University, Montreal, QC H3A 0G4, Canada.

Patricia T Yam (PT)

Montreal Clinical Research Institute (IRCM), 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada.

Nursen Balekoglu (N)

Montreal Clinical Research Institute (IRCM), 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada.
Integrated Program in Neuroscience, McGill University, Montreal, QC H3A 2B4, Canada.

Hugo Ducuing (H)

Montreal Clinical Research Institute (IRCM), 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada.

Jean-Francois Michaud (JF)

Montreal Clinical Research Institute (IRCM), 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada.

Shirin Makihara (S)

Montreal Clinical Research Institute (IRCM), 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada.
Integrated Program in Neuroscience, McGill University, Montreal, QC H3A 2B4, Canada.

Daniel K Kramer (DK)

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA.

Baoyu Chen (B)

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA.

Alfonso Fasano (A)

Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, ON, Canada.
Division of Neurology, University of Toronto, Toronto, ON, Canada.
Krembil Brain Institute, Toronto, ON, Canada.

Alfredo Berardelli (A)

IRCCS Neuromed, Pozzilli (IS), Italy.
Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Fadi F Hamdan (FF)

Division of Medical Genetics, Department of Pediatrics, CHU Sainte-Justine and University of Montreal, Montreal, QC H3T1C5, Canada.

Guy A Rouleau (GA)

Division of Medical Genetics, Department of Pediatrics, CHU Sainte-Justine and University of Montreal, Montreal, QC H3T1C5, Canada.
Department of Human Genetics, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.

Myriam Srour (M)

Department of Neurology and Neurosurgery, McGill University, Montreal, QC H3A 2B4, Canada.
Department of Pediatrics, Division of Pediatric Neurology, McGill University, Montreal, QC H4A 3J1, Canada.
McGill University Health Center Research Institute, Montreal, QC H4A 3J1, Canada.

Frederic Charron (F)

Montreal Clinical Research Institute (IRCM), 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada.
Department of Anatomy and Cell Biology, Division of Experimental Medicine, McGill University, Montreal, QC H3A 0G4, Canada.
Integrated Program in Neuroscience, McGill University, Montreal, QC H3A 2B4, Canada.
Department of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada.

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