Synthesis of water-soluble novel bioactive pyridine-based azo coumarin derivative and competitive cytotoxicity, DNA binding, BSA binding study, and in silico analysis with coumarin.
Aqueous medium
Azo derivative
BSA binding
Coumarin
Cytotoxicity
DNA binding
LN-229
Molecular docking
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
07
02
2023
revised:
02
04
2023
accepted:
05
04
2023
medline:
10
7
2023
pubmed:
13
5
2023
entrez:
12
5
2023
Statut:
ppublish
Résumé
The diazo coupliling reaction of 3- amino pyridine with coumarin in water medium produces water soluble 6-[3-pyridyl]azocoumarin. The synthesised compound has been fully charecterised by IR, NMR, and Mass spectroscopy. The frontier molecular orbital calculations reveal that 6-[3-pyridyl]azocoumarin is more biologically and chemically active in comparison to coumarin. The cytotoxicity evaluation confirms that 6-[3-pyridyl]azocoumarin is more active than coumarin against human brain glioblastoma cell lines, LN-229 with IC
Identifiants
pubmed: 37172438
pii: S0045-2068(23)00192-X
doi: 10.1016/j.bioorg.2023.106532
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
DNA
9007-49-2
Organic Chemicals
0
Pyridines
0
Coumarins
0
Water
059QF0KO0R
Serum Albumin, Bovine
27432CM55Q
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106532Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.